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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/30 22:34:59」(JST)

Ioxaglic acid (trade name Hexabrix) is an iodine containing molecule used as a low-osmolality contrast medium.^[1]

References

^ Meijenhorst, G. C.; De Bruin, J. N. (1980). "Hexabrix (ioxaglate), a new low osmolality contrast agent for lumbar epidural double-catheter venography". Neuroradiology 20 (1): 29–32. PMID 6999377. edit

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1. 造影剤に対する即時型過敏反応：臨床症状、診断、および治療 immediate hypersensitivity reactions to radiocontrast media clinical manifestations diagnosis and treatment
2. 造影剤に対する即時型過敏反応：再発反応の予防 immediate hypersensitivity reactions to radiocontrast media prevention of recurrent reactions
3. 造影剤誘発性腎症の予防 prevention of contrast induced nephropathy

Evaluation of intrarenal oxygenation in iodinated contrast-induced acute kidney injury-susceptible rats by blood oxygen level-dependent magnetic resonance imaging.

Li LP1, Lu J, Zhou Y, Papadopoulou MV, Franklin T, Bokhary U, Solomon R, Sen A, Prasad PV.
Investigative radiology.Invest Radiol.2014 Jun;49(6):403-10. doi: 10.1097/RLI.0000000000000031.
OBJECTIVES: The objectives of this study were to evaluate differences in intrarenal oxygenation as assessed by blood oxygen level-dependent (BOLD) magnetic resonance imaging in contrast-induced acute kidney injury (CIAKI)-susceptible rats when using 4 contrast media with different physicochemical pr
PMID 24566288

Efficacy of Preventive Interventions for Iodinated Contrast-Induced Acute Kidney Injury Evaluated by Intrarenal Oxygenation as an Early Marker.

Li LP1, Thacker J, Lu J, Franklin T, Zhou Y, Papadopoulou MV, Solomon R, Prasad PV.
Investigative radiology.Invest Radiol.2014 May 27. [Epub ahead of print]
OBJECTIVE: The objective of this study was to evaluate the effects of potential renoprotective interventions such as the administration of N-acetylcysteine (NAC; antioxidant) and furosemide (diuretic) on intrarenal oxygenation as evaluated by blood oxygen level-dependent (BOLD) magnetic resonance im
PMID 24872003

A meta-analysis of the risk of total cardiovascular events of isosmolar iodixanol compared with low-osmolar contrast media.

Zhang BC1, Wu Q2, Wang C3, Li DY3, Wang ZR3.
Journal of cardiology.J Cardiol.2014 Apr;63(4):260-8. doi: 10.1016/j.jjcc.2013.11.021. Epub 2014 Jan 4.
BACKGROUND: The iso-osmolar contrast agent iodixanol may be associated with a lower incidence of cardiac events than low-osmolar contrast media (LOCM), but previous trials have yielded mixed results.OBJECTIVE: To compare the risk of total cardiovascular events of the iso-osmolar contrast medium, iod
PMID 24397991

リンク元	「イオキサグル酸」「イオキサグレート」「ioxaglic acid」

Ioxaglic acid
Systematic (IUPAC) name
	3-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodo-5-(2-{[2,4,6-triiodo-3-(methylcarbamoyl)-5-(N-methylacetamido)phenyl]formamido}acetamido)benzoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
ATC code	V08AB03
PubChem	CID: 3742
ChemSpider	3611
UNII	Z40X7EI2AF
KEGG	D01761
ChEMBL	CHEMBL1201291
Chemical data
Formula	C24H21I6N5O8
Molecular mass	1268.87906 g/mol
	SMILES CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I)C(=O)NC)I ;
	InChI InChI=1S/C24H21I6N5O8/c1-7(37)35(3)20-17(29)10(21(39)31-2)13(25)11(18(20)30)23(41)33-6-8(38)34-19-15(27)9(22(40)32-4-5-36)14(26)12(16(19)28)24(42)43/h36H,4-6H2,1-3H3,(H,31,39)(H,32,40)(H,33,41)(H,34,38)(H,42,43) ; Key:TYYBFXNZMFNZJT-UHFFFAOYSA-N ;