ヨードチロシン
- 関
- monoiodotyrosine
WordNet
- tyrosine with iodine added
- tyrosine with two iodine atoms added
- tyrosine with one iodine atom added
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/14 15:58:03」(JST)
[Wiki en表示]
Monoiodotyrosine |
|
Identifiers |
CAS number |
29592-76-5 |
PubChem |
3032857 |
MeSH |
Monoiodotyrosine |
Properties |
Molecular formula |
C9H10INO3 |
Molar mass |
307.085 g/mol |
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Monoiodotyrosine is a precursor of thyroid hormone and results from iodization of tyrosine at the meta- position of the phenol ring.
Two units can combine to form 3,3'-diiodothyronine. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle.
It is abbreviated "MIT".[1]
References
- ^ Tietze F, Kohn LD, Kohn AD, et al (March 1989). "Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes". J. Biol. Chem. 264 (9): 4762–5. PMID 2925666. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2925666.
Thyroid hormone metabolic intermediates
|
|
Tyrosine / iodotyrosine |
- Monoiodotyrosine
- Diiodotyrosine
|
|
Thyronine / iodothyronine |
- 3'-Monoiodothyronine
- 3,3'-Diiodothyronine
- 3,3',5-Triiodothyronine (T3)
- 3,3',5'-Triiodothyronine (Reverse T3)
- 3,5,3',5'-Tetraiodothyronine (Thyroxine, T4)
|
|
Thyronamine / iodothyronamine |
- 3-Iodothyronamine
- 3,3',5-Triiodothyronamine
|
|
|
mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
|
k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
|
|
|
|
noco (d)/cong/tumr, sysi/epon
|
proc, drug (A10/H1/H2/H3/H5)
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Species-specific lipophilicity of thyroid hormones and their precursors in view of their membrane transport properties.
- Tóth G, Mazák K, Hosztafi S, Kökösi J, Noszál B.SourceDepartment of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Budapest H-1092, Hőgyes Endre u. 9, Hungary.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 25;76:112-8. doi: 10.1016/j.jpba.2012.12.010. Epub 2012 Dec 20.
- A total of 30 species-specific partition coefficients of three thyroid hormones (thyroxine, liothyronine, reverse liothyronine) and their two biological precursors (monoiodotyrosine, diiodotyrosine) are presented. The molecules were studied using combined methods of microspeciation and lipophilicity
- PMID 23298914
- Ultraviolet action spectroscopy of iodine labeled peptides and proteins in the gas phase.
- Kirk BB, Trevitt AJ, Blanksby SJ, Tao Y, Moore BN, Julian RR.SourceARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry, University of Wollongong, New South Wales 2522, Australia.
- The journal of physical chemistry. A.J Phys Chem A.2013 Feb 14;117(6):1228-32. doi: 10.1021/jp305470j. Epub 2012 Aug 20.
- Structural investigations of large biomolecules in the gas phase are challenging. Herein, it is reported that action spectroscopy taking advantage of facile carbon-iodine bond dissociation can be used to examine the structures of large molecules, including whole proteins. Iodotyrosine serves as the
- PMID 22906129
- Direct activation of Xenopus iodotyrosine deiodinase by thyroid hormone receptor in the remodeling intestine during amphibian metamorphosis.
- Fujimoto K, Matsuura K, Das B, Fu L, Shi YB.SourceSection on Molecular Morphogenesis, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
- Endocrinology.Endocrinology.2012 Oct;153(10):5082-9. Epub 2012 Aug 3.
- Thyroid hormone (TH) plays critical roles during vertebrate postembryonic development. TH production in the thyroid involves incorporating inorganic iodide into thyroglobulin. The expression of iodotyrosine deiodinase (IYD; also known as iodotyrosine dehalogenase 1) in the thyroid gland ensures effi
- PMID 22865369
Japanese Journal
- Iodotyrosine Deiodinase, a Novel Target of Environmental Halogenated Chemicals for Disruption of the Thyroid Hormone System in Mammals
- PCBおよびPBDEの水酸化代謝物のヨードチロシン脱ヨウ素化酵素阻害作用における構造活性相関
- Inhibitory effects of halogenated environmental chemicals on iodotyrosine deiodinase activity
Related Links
- Iodotyrosine deiodinase also known as iodotyrosine dehalogenase 1 is an enzyme that in humans is encoded by the IYD gene. It helps scavenge iodine by removing it from iodinated tyrosines, after these are produced when thyroid hormones ...
Related Pictures
★リンクテーブル★
[★]
- 日
- 関
- 同
- MIT
- 同
- MIT
- 同
- MIT
- 同
- MIT
[★]
ジヨードチロシン DIT