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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/23 03:52:14」(JST)

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Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.

Function

DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).^[1]

Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).

Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').

References

^ Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.

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UpToDate Contents

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1. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
2. 甲状腺機能の臨床検査評価 laboratory assessment of thyroid function
3. 橋本病（慢性自己免疫性甲状腺炎）の病因 pathogenesis of hashimotos thyroiditis chronic autoimmune thyroiditis

English Journal

Effects of 3,5-Diiodotyrosine and Potassium Iodide on Thyroid Function and Oxidative Stress in Iodine-Excess Wistar Rats.

Liu D1, Lin X2, Yu F3, Zhang M1, Chen H4, Bao W5, Wang X6.
Biological trace element research.Biol Trace Elem Res.2015 Dec;168(2):447-52. doi: 10.1007/s12011-015-0371-y. Epub 2015 May 24.
The objective of this study was to investigate the effects of organic iodine (3,5-diiodotyrosine, DIT) and inorganic iodine (potassium iodine, KI) on thyroid function and oxidative stress in iodine-excess Wistar rats. Seventy-two Wistar rats were randomly divided into eight groups: normal control (N
PMID 26002813

Thyroglobulin from Molecular and Cellular Biology to Clinical Endocrinology.

Di Jeso B1, Arvan P2.
Endocrine reviews.Endocr Rev.2015 Nov 23:er20151090. [Epub ahead of print]
Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER) where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization. Its primary functions include iodide storage
PMID 26595189

Ion pair hollow fiber liquid-liquid-liquid microextraction combined with capillary electrophoresis-ultraviolet detection for the determination of thyroid hormones in human serum.

Li P1, Hu B2, He M1, Chen B1.
Journal of chromatography. A.J Chromatogr A.2014 Aug 22;1356:23-31. doi: 10.1016/j.chroma.2014.06.046. Epub 2014 Jun 21.
In this study, a novel, inexpensive, sensitive and selective analytical method that combines ion pair hollow fiber liquid-liquid-liquid microextraction (IP-HF-LLLME) with capillary electrophoresis-ultraviolet detection (CE-UV) was developed for the simultaneous determination of six thyroid hormones
PMID 24997114

Japanese Journal

STUDIES ON EXPERIMENTAL IODINE ALLERGY : 3. LOW MOLECULAR WEIGHT ELICITOGENIC ANTIGENS OF IODINE ALLERGY

Sugihara Yoshiki,Shionoya Hiroshi,Okano Kazuo [他],SAGAMI Fumio,MIKAMI Takashi,KATAYAMA Kouichi
Journal of toxicological sciences 29(2), 147-154, 2004-05-28
… Since an antigenic determinant of experimental iodine allergy is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative antigenicity without sensitizing immunogenicity. …
NAID 110001812867

ヨウ素化合物の研究(第10報) : Glycyltyrosineのヨウ素化合物の単離精製法

宮下正弘,松永吏世,瀬山義幸 [他],山下三郎
藥學雜誌 119(9), 681-687, 1999-09-01
… The methods for the isolation and purification of iodoglycyltyrosines [glycyl-3-iodotyrosine (Gly-MIT) and glycyl-3,5-diiodotyrosine (Gly-DIT)] from a reaction mixture were examined by the use of high-performance liquid chromatography (HPLC). …
NAID 110003648768

Purification and Characterization of Turtle Pepsinogen and Pepsin.

Hirasawa Akira,Athauda Senarath B.P.,Takahashi Kenji
The Journal of Biochemistry 120(2), 407-414, 1996
… The nine isoforms showed similar specific activity toward hemoglobin and hydrolyzed N-acetyl-L-phenylalanyl-L-diiodotyrosine, a good substrate for pepsin A, at somewhat different rates. …
NAID 130003532964

Related Pictures

★リンクテーブル★

リンク元	「DIT」「ジヨードチロシン」

「DIT」

Diiodotyrosine
Identifiers
CAS Registry Number	66-02-4
ChemSpider	8946
	InChI InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1 ; Key: NYPYHUZRZVSYKL-ZETCQYMHSA-N ; InChI=1/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1; Key: NYPYHUZRZVSYKL-ZETCQYMHBZ ;
IUPHAR/BPS	6651
Jmol-3D images	Image
MeSH	Diiodotyrosine
PubChem	6181; 7058163
	SMILES Ic1cc(cc(I)c1O)C[C@@H](C(=O)O)N ;
UNII	6L57Q44ZWW
Properties
Chemical formula	C9H9I2NO3
Molar mass	432.982 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

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「ジヨードチロシン」

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英: diiodotyrosine, DIT
関: 甲状腺ホルモン, 甲状腺内ヨウ素回路

[pmid1149735-1] Dème D, Fimiani E, Pommier J, Nunez J (February 1975). "Free diiodotyrosine effects on protein iodination and thyroid hormone synthesis catalyzed by thyroid peroxidase". Eur. J. Biochem. 51 (2): 329–36. doi:10.1111/j.1432-1033.1975.tb03932.x. PMID 1149735.

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diiodotyrosine