intraepithelial lymphocytes

同

IELs

同

IELs

WordNet

1. an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection (同)lymph cell

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/04 11:06:05」(JST)

wiki en

[Wiki en表示]

primary biliary cirrhosis. Bile duct intraepithelial lymphocytes

Intraepithelial lymphocytes (IEL) are lymphocytes found in the epithelial layer of mammalian mucosal linings, such as the gastrointestinal (GI) tract and reproductive tract. However, unlike other T cells, IELs do not need priming. Upon encountering antigens, they immediately release cytokines and cause killing of infected target cells. In the GI tract, they are components of gut-associated lymphoid tissue (GALT).

Pathology

An elevated IEL population, as determined by biopsy, typically indicates ongoing inflammation within the mucosa. In diseases such as celiac sprue, IEL elevation throughout the small intestine is one of many specific markers.

Alternatively, elevated IEL populations can be a marker for developing neoplasia in the tissue such as found in cervical and prostate cancers, as well as some colorectal cancers, particularly those associated with Lynch syndrome (hereditary non-polyposis colon cancer <HNPCC>). IELs themselves can of course, undergo mutation to become lymphoma.

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 食物アレルギーの病因pathogenesis of food allergy [show details]
  … provides a physical barrier that is enhanced by the presence of inflammatory cells . Intraepithelial lymphocytes (IELs) of the gut are critical to the immune response. The submucosa is colonized by numerous …
• 2. 成人におけるセリアック病の診断diagnosis of celiac disease in adults [show details]
  …disease in the small intestine range from a mild alteration characterized only by increased intraepithelial lymphocytes, to a severely atrophic mucosa with complete loss of villi, enhanced epithelial apoptosis …
• 3. 腸症型T細胞性リンパ腫の臨床症状、病理学的特徴、および診断clinical manifestations pathologic features and diagnosis of enteropathy associated t cell lymphoma [show details]
  …hyperplasia, an increased number of lymphocytes and plasma cells in the lamina propria, and intraepithelial lymphocytes . Pathologic evidence of celiac disease may depend on the segment analyzed, since in celiac …
• 4. 顕微鏡的大腸炎（リンパ球浸潤大腸炎および膠原線維性大腸炎：臨床症状、診断、マネージメントmicroscopic lymphocytic and collagenous colitis clinical manifestations diagnosis and management [show details]
  …to be thickened. Lymphocytic colitis – Lymphocytic colitis is characterized by ≥20 intraepithelial lymphocytes (IEL) per 100 surface epithelial cells . Crypt architecture is usually not distorted, but …
• 5. IgGの構造および生物学的機能structure and biologic functions of iga [show details]
  …the intestinal microbial ecology may cause activation of mucosal immune cells, including intraepithelial lymphocytes, cells of the isolated lymphoid follicles, Peyer patches, and mesenteric lymph nodes. In…

English Journal

• Histological Development of the Immune Tissues of a Marsupial, the Red-Tailed Phascogale (Phascogale calura).

• Borthwick CR1, Old JM1.
• Anatomical record (Hoboken, N.J. : 2007).Anat Rec (Hoboken).2016 Feb;299(2):207-19. doi: 10.1002/ar.23297. Epub 2015 Dec 18.
• Red-tailed phascogale (Phascogale calura) pouch young at birth were relatively underdeveloped in comparison with their eutherian counterparts, and the lymphoid tissues of the immune system were found to be histologically immature. The phascogale thymus rapidly developed in the first few days of pouc
• PMID 26599205

• Potential coeliac disease markers and autoimmunity in olmesartan induced enteropathy: A population-based study.

• Esteve M1, Temiño R2, Carrasco A3, Batista L2, Del Val A4, Blé M4, Santaolaria S5, Molina-Infante J6, Soriano G7, Agudo S8, Zabana Y3, Andújar X3, Aceituno M3, Ribes J9, Madridejos R10, Fernández-Bañares F3.
• Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.Dig Liver Dis.2016 Feb;48(2):154-61. doi: 10.1016/j.dld.2015.09.014. Epub 2015 Oct 22.
• AIMS: (1) Assess the population-based incidence of severe olmesartan-associated enteropathy. (2) To describe patients of the Spanish registry. (3) Evaluate markers of potential coeliac disease and associated autoimmunity.METHODS: Crude incidence rates in the area of Terrassa (Catalonia) were calcula
• PMID 26699826

• Two highly adhesive lactic acid bacteria strains are protective in zebrafish infected with Aeromonas hydrophila by evocation of gut mucosal immunity.

• Wang Y1, Ren Z1, Fu L1, Su X2.
• Journal of applied microbiology.J Appl Microbiol.2016 Feb;120(2):441-451. doi: 10.1111/jam.13002.
• AIMS: To increase the knowledge of probiotic effects and potential mechanisms, we report on the use of the zebrafish model to investigate the in vivo colonization ability, as well as the protective effects associated with gut mucosal immune barrier and responses against Aeromonas hydrophila infecti
• PMID 26555459

Japanese Journal

• Evaluation of intraepithelial lymphocytes, goblet cells and immunoglobulin genes in the intestinal mucosal tissue of Pelodiscus sinensis after challenge with Aeromonas veronii bv. sobria and lipopolysaccharide

• Xu Jiehao,Chen Hanxiang,Zhang Wanrong,Xu Haisheng
• Fisheries science 85(1), 177-185, 2019-01
• NAID 40021782116

• 口腔扁平苔癬の悪性化に関する免疫組織学的検討

• 太田 尚克
• 北海道歯学雑誌 38(2), 195-202, 2018-03
• … Immunohistochemical experiments were performed with anti-CD3, anti-CD8, and anti- CD20 antibody for subepithelial lymphocytes, with anti-CD68 antibody for intraepithelial dendritic cells and anti-p53, Ki-67 and anti-podoplanin antibody for epithelial cells. …
• NAID 120006454510

• Colonal monomorphic epitheliotropic intestinal T-cell lymphoma with novel phenotype of cytoplasmic CD3 expression

• Aoyama Yumi,Tsunemine Hiroko,Zushi Yuriko,Maruoka Hayato,Goto Yuta,Kodaka Taiichi,Itoh Tomoo,Takahashi Takayuki
• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ 58(2), 102-106, 2018
• … Histopathological examination of the mucosal biopsy specimen demonstrated dense infiltration of small lymphocytes with nuclear atypia, some of which exhibited intraepithelial invasion. … Immunohistologically, these lymphocytes were positive for CD3, CD56, and perforin. …
• NAID 130007403949

Related Pictures

---

★リンクテーブル★

関連記事	「lymphocyte」

「lymphocyte」

　　[★] リンパ球

同

lymphocytes＆development