intolerable

WordNet

incapable of being put up with; "an intolerable degree of sentimentality" (同)unbearable, unendurable

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1. 苦痛緩和のための鎮静 palliative sedation
2. 終末期の効果的な疼痛マネージメントにおける倫理的問題 ethical considerations in effective pain management at the end of life
3. 非侵襲的陽圧換気に伴う問題のトラブルシューティング troubleshooting problems with noninvasive positive pressure ventilation
4. 慢性閉塞性肺疾患（COPD）患者における肺過膨張 dynamic hyperinflation in patients with copd
5. 小児および思春期における注意欠陥多動性障害：薬物治療 attention deficit hyperactivity disorder in children and adolescents treatment with medications

Following the Ions through a Mass Spectrometer with Atmospheric Pressure Interface: Simulation of Complete Ion Trajectories from Ion Source to Mass Analyzer.

Zhou X1, Ouyang Z1.
Analytical chemistry.Anal Chem.2016 Jul 19;88(14):7033-40. doi: 10.1021/acs.analchem.6b00461. Epub 2016 Jul 8.
Ion trajectory simulation is an important and useful tool in instrumentation development for mass spectrometry. Accurate simulation of the ion motion through the mass spectrometer with atmospheric pressure ionization source has been extremely challenging, due to the complexity in gas hydrodynamic fl
PMID 27340893

Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.

Morioka H1, Takahashi S2, Araki N3, Sugiura H4, Ueda T5, Takahashi M6, Yonemoto T7, Hiraga H8, Hiruma T9, Kunisada T10, Matsumine A11, Susa M12, Nakayama R12, Nishimoto K12, Kikuta K12, Horiuchi K12, Kawai A13.
BMC cancer.BMC Cancer.2016 Jul 14;16(1):479. doi: 10.1186/s12885-016-2511-y.
BACKGROUND: Trabectedin is reported to be particularly effective against translocation-related sarcoma. Recently, a randomized phase 2 study in patients with translocation-related sarcomas unresponsive or intolerable to standard chemotherapy was conducted, which showed clinical benefit of trabectedi
PMID 27418251

Chua AL1, Silberstein S1.
Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2016 Jul 14. [Epub ahead of print]
INTRODUCTION: Currently, migraine abortive therapies are available in oral, intranasal, injectable, transdermal, suppository and intravenous routes. These formulations each come with their own set of challenges, such as poor bioavailability, intolerable side effects or inconvenient administration. T
PMID 27416108