English Journal

The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.

Martino T1, Magalhães FC1, Justo GA1, Coelho MG1, Netto CD2, Costa PR2, Sabino KC3.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Apr 20. pii: S0968-0896(14)00279-X. doi: 10.1016/j.bmc.2014.04.025. [Epub ahead of print]
The incidence of cancer grows annually worldwide and in Brazil it is the second cause of death. The search for anti-cancer drugs has then become urgent. It depends on the studies of natural and chemical synthesis products. The antitumor action of LQB-118, a pterocarpanquinone structurally related to
PMID 24794748

Isw1a does not have strict limitations on the length of extranucleosomal DNAs for mobilization of nucleosomes assembled with HeLa cell histones.

Krajewski WA.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Apr;32(4):523-31. doi: 10.1080/07391102.2013.782823. Epub 2013 Apr 13.
The Saccharomyces cerevisiae Isw1a and Isw2 ATP-dependent chromatin-remodeling complexes have important roles in vivo in the regulation of nucleosome positioning and modulation of gene activity. We studied the ability of the Isw1a- and Isw2-remodeling enzymes to reposition nucleosomes in mono- and d
PMID 23581908

Cytotoxic effects of procyanidins from Castanea mollissima Bl. shell on human hepatoma G2 cells in vitro.

Zhang H1, Ke J1, Shao T1, Li J1, Duan Y2, He Y1, Zhang C1, Chen G3, Sun G4, Sun X5.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2014 Feb;64:166-76. doi: 10.1016/j.fct.2013.11.026. Epub 2013 Nov 28.
Significant cytotoxic effects of procynadins from chestnut (Castanea mollissima Bl.) shell (CSPC) on human hepatoma G2 (HepG2) cells were found in vitro. CSPC could inbibit HepG2 proliferation in a dose-dependent manner (100-400 μg/mL), arrest cell cycle in the G0/G1 phase, induce apoptosis and tri
PMID 24291453

Japanese Journal

Fangchinoline Inhibits Breast Adenocarcinoma Proliferation by Inducing Apoptosis

Xing Zhi-Bo,Yao Lei,Zhang Guo-Qiang,Zhang Xian-Yu,Zhang You-Xue,Pang Da
Chemical and Pharmaceutical Bulletin 59(12), 1476-1480, 2011
… Fangchinoline induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspases-3, -8, and -9, and cleavage of poly(ADP ribose) polymerase, as well as enhanced mitochondrial cytochrome c release. …
NAID 130001852121

The In Vitro Approach to the Cytotoxicity of a Trichothecene Mycotoxin Nivalenol

NAGASHIMA Hitoshi,NAKAGAWA Hiroyuki,KUSHIRO Masayo,IWASHITA Keiko
Japan Agricultural Research Quarterly: JARQ 43(1), 7-11, 2009
… At 3 and 10 μg/mL, internucleosomal DNA fragmentation, one of the hallmarks of apoptosis, was apparent. …
NAID 130002147817

Fatty Acid Synthase Inhibition by Amentoflavone Induces Apoptosis and Antiproliferation in Human Breast Cancer Cells

Lee Jin Sun,Lee Myung Sun,Oh Won Keun [他],Sul Ji Young
Biological and Pharmaceutical Bulletin 32(8), 1427-1432, 2009
… The sequential internucleosomal DNA fragmentation in SK-BR-3 cells was observed at a concentration of 100 μM. …
NAID 130000117259