interleukin-21 receptor

インターロイキン21受容体

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/16 18:24:28」(JST)

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IL21R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TGX, 4NZD
Identifiers
Aliases	IL21R, CD360, NILR, interleukin 21 receptor
External IDs	MGI: 1890475 HomoloGene: 11040 GeneCards: IL21R
Gene ontology Molecular function • cytokine receptor activity • interleukin-21 receptor activity Cellular component • integral component of membrane • membrane Biological process • natural killer cell activation • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50615	60504
Ensembl	ENSG00000103522	ENSMUSG00000030745
UniProt	Q9HBE5	Q9JHX3
RefSeq (mRNA)	NM_021798 NM_181078 NM_181079	NM_021887
RefSeq (protein)	NP_068570.1 NP_851564.1 NP_851565.4	NP_068687.1
Location (UCSC)	Chr 16: 27.4 – 27.45 Mb	Chr 7: 125.6 – 125.63 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.

References

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–3. PMID 7566098. 
• Ozaki K, Kikly K, Michalovich D, et al. (2000). "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11439–11444. doi:10.1073/pnas.200360997. PMC 17218. PMID 11016959. 
• Parrish-Novak J, Dillon SR, Nelson A, et al. (2000). "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function". Nature. 408 (6808): 57–63. doi:10.1038/35040504. PMID 11081504. 
• Asao H, Okuyama C, Kumaki S, et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. 
• Jüngel A, Distler JH, Kurowska-Stolarska M, et al. (2004). "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis". Arthritis Rheum. 50 (5): 1468–1476. doi:10.1002/art.20218. PMID 15146416. 
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Distler JH, Jüngel A, Kowal-Bielecka O, et al. (2005). "Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis". Arthritis Rheum. 52 (3): 856–864. doi:10.1002/art.20883. PMID 15751077. 
• Wu Z, Kim HP, Xue HH, et al. (2005). "Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity". Mol. Cell. Biol. 25 (22): 9741–9752. doi:10.1128/MCB.25.22.9741-9752.2005. PMC 1280258. PMID 16260592. 
• de Totero D, Meazza R, Zupo S, et al. (2006). "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells". Blood. 107 (9): 3708–3715. doi:10.1182/blood-2005-09-3535. PMID 16391014. 
• Pène J, Guglielmi L, Gauchat JF, et al. (2007). "IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene". J. Immunol. 177 (8): 5006–13. doi:10.4049/jimmunol.177.8.5006. PMID 17015683. 
• Li J, Shen W, Kong K, Liu Z (2006). "Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis". Scand. J. Immunol. 64 (5): 515–522. doi:10.1111/j.1365-3083.2006.01795.x. PMID 17032244. 
• Asano K, Ikegami H, Fujisawa T, et al. (2007). "Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes". Hum. Immunol. 68 (5): 384–391. doi:10.1016/j.humimm.2007.01.009. PMID 17462506. 
• Akamatsu N, Yamada Y, Hasegawa H, et al. (2007). "High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma". Cancer Lett. 256 (2): 196–206. doi:10.1016/j.canlet.2007.06.001. PMID 17624663. 

UpToDate Contents

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• 3. インスリン受容体の構造および機能 structure and function of the insulin receptor
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• 5. T細胞受容体の遺伝学 t cell receptor genetics

English Journal

• Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R.

• Hamming OJ, Kang L, Svensson A, Karlsen JL, Rahbek-Nielsen H, Paludan SR, Hjorth SA, Bondensgaard K, Hartmann R.SourceFrom the Departments of Molecular Biology and Genetics and.
• The Journal of biological chemistry.J Biol Chem.2012 Mar 16;287(12):9454-60. Epub 2012 Jan 10.
• IL-21 is a class I cytokine that exerts pleiotropic effects on both innate and adaptive immune responses. It signals through a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common γ-chain. A hallmark of the class I cytokine receptors is the class I cytokine recept
• PMID 22235133

• Cutting edge: IL-21 derived from human follicular helper T cells acts as a survival factor for secondary lymphoid organ, but not for bone marrow, plasma cells.

• Rodríguez-Bayona B, Ramos-Amaya A, Bernal J, Campos-Caro A, Brieva JA.SourceServicio de Inmunología, Unidad de Investigación, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Feb 15;188(4):1578-81. Epub 2012 Jan 16.
• IL-21 induces the differentiation of activated B lymphocytes into plasma cells (PC), but its direct effect on PC remains uncertain. This study analyzes the role of IL-21 on human in vivo-generated PC. IL-21R was clearly expressed on PC from the human tonsil, the lymph node, and the spleen (secondary
• PMID 22250083

Japanese Journal

• interleukin21(IL-21)とその可溶型受容体間の相互作用解析

• 真壁 幸樹,津本 浩平,浅野 竜太郎,熊谷 泉
• 生物物理 43(SUPPLEMENT_1), S73, 2003-08-25
• NAID 110001157925

• The gene for interleukin-21 receptor is the partner of BCL6 in t(3 ; 16)(q27 ; p11), which is recurrently observed in diffuse large B-cell lymphoma

• UEDA C
• Oncogene 21, 368-376, 2002
• NAID 30013802275

• Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

• PARRISH-NOVAK J.
• Nature 408, 57-63, 2000
• NAID 80012164321

Related Links

• IL21R interleukin 21 receptor [ (human)] - National Center for ...

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain ...

• OMIM Entry - * 605383 - INTERLEUKIN 21 RECEPTOR; IL21R

605383 - INTERLEUKIN 21 RECEPTOR; IL21R - IL21R/BCL6 FUSION GENE, INCLUDED - IL21R Home About Statistics Downloads Help External Links ...

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★リンクテーブル★

リンク元	「インターロイキン21受容体」
拡張検索	「interleukin-21 receptor alpha subunit」
関連記事	「interleukin」「interleukins」

「インターロイキン21受容体」

　　[★]

英

interleukin-21 receptor

「interleukin-21 receptor alpha subunit」

　　[★]

• インターロイキン21受容体αサブユニット

「interleukin」

　　[★] インターロイキン IL 　

「interleukins」

　　[★] インターロイキン IL