WordNet

first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
any high mountain

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1. 複合免疫不全 combined immunodeficiencies
2. リウマチ性疾患のマネージメントに用いる生物学的製剤とキナーゼ阻害薬の概要 overview of biologic agents and kinase inhibitors in the rheumatic diseases
3. クローン病の内科的マネージメントにおける試験研究治療 investigational therapies in the medical management of crohn disease
4. 選択的IgA欠損症：臨床症状、病態生理、および診断 selective iga deficiency clinical manifestations pathophysiology and diagnosis
5. 原発性免疫不全症患者における自己免疫 autoimmunity in patients with primary immunodeficiency

Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice.

Stamatopoulos A, Stamatopoulos T, Gamie Z, Kenanidis E, Ribeiro RDC, Rankin KS, Gerrand C, Dalgarno K, Tsiridis E.
Journal of bone oncology. 2019 Jun;16()100231.
Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of l
PMID 30956944

IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer.

Yan L, Zhang J, Guo D, Ma J, Shui SF, Han XW.
International journal of oncology. 2019 Jan;54(1)7-16.
Interleukin-21 receptor (IL-21R) is involved in the immunological regulation of immune cells and tumor progression in multiple malignancies. However, the potential molecular mechanisms through which non-coding RNAs (ncRNAs) modulate IL-21R signaling in gastric cancer (GC) remain elusive. In this s
PMID 30387833

Interleukin-22 promotes phagolysosomal fusion to induce protection against Typhimurium in human epithelial cells.

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.
Proceedings of the National Academy of Sciences of the United States of America. 2018 10;115(40)10118-10123.
Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence that IL-22 primed intestinal organoids derived from healthy human induced
PMID 30217896