- 同
- interleukin-1 receptors
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/13 03:57:36」(JST)
[Wiki en表示]
interleukin 1 receptor, type I |
Identifiers |
Symbol |
IL1R1 |
Alt. symbols |
IL1R, IL1RA |
Entrez |
3554 |
HUGO |
5993 |
OMIM |
147810 |
RefSeq |
NM_000877 |
UniProt |
P14778 |
Other data |
Locus |
Chr. 2 q12 |
interleukin 1 receptor, type II |
Identifiers |
Symbol |
IL1R2 |
Alt. symbols |
IL1RB |
Entrez |
7850 |
HUGO |
5994 |
OMIM |
147811 |
RefSeq |
NM_173343 |
UniProt |
P27930 |
Other data |
Locus |
Chr. 2 q12 |
interleukin 1 receptor accessory protein |
Identifiers |
Symbol |
IL1RAP |
Alt. symbols |
IL-1RAcP, IL1R3, C3orf13 |
Entrez |
3556 |
HUGO |
5995 |
OMIM |
602626 |
RefSeq |
NM_134470 |
UniProt |
Q9NPH3 |
Other data |
Locus |
Chr. 3 q28 |
See also: Interleukin-1 receptor family
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
References
- ^ a b Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (ABSTRACT PAGE). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161.
- ^ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
- ^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External links
- Receptors, Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors.
- Hantel C1, Ozimek A2, Lira R3, Ragazzon B4, Jäckel C5, Frantsev R6, Reincke M6, Bertherat J4, Mussack T2, Beuschlein F6.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Mar 5;423:87-95. doi: 10.1016/j.mce.2015.12.009. Epub 2016 Jan 6.
- ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical trials performed poorly. Our aim was to inves
- PMID 26768118
- Immunoreactivities of IL-1β and IL-1R in oviduct of Chinese brown frog (Rana dybowskii) during pre-hibernation and the breeding period.
- Hu R1, Liu Y1, Deng Y1, Ma S1, Sheng X1, Weng Q1, Xu M2.
- Acta histochemica.Acta Histochem.2016 Mar;118(2):164-9. doi: 10.1016/j.acthis.2015.12.006. Epub 2015 Dec 30.
- The Chinese brown frog (Rana dybowskii) has one special physiological phenomenon, which is that its oviduct goes through expansion prior to hibernation instead of during the breeding period. In this study, we investigated the localization and expression level of interleukin-1 (IL-1β) and its functi
- PMID 26746863
- Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?
- Fernandes P1, MacSharry J2, Darby T3, Fanning A2, Shanahan F2,4, Houston A2,4, Brint E2,5.
- Clinical and experimental immunology.Clin Exp Immunol.2016 Mar;183(3):358-68. doi: 10.1111/cei.12732. Epub 2015 Nov 26.
- The innate immune system is currently seen as the probable initiator of events which culminate in the development of inflammatory bowel disease (IBD) with Toll-like receptors (TLRs) known to be involved in this disease process. Many regulators of TLRs have been described, and dysregulation of these
- PMID 26462859
Japanese Journal
- Serum amyloid A triggers the mosodium urate -mediated mature interleukin-1β production from human synovial fibroblasts
- Migita Kiyoshi,Koga Tomohiro,Satomura Kenshi,Izumi Masahiro,Torigoshi Takafumi,Maeda Yumi,Izumi Yasumori,Jiuchi Yuka,Miyashita Taiichiro,Yamasaki Satoshi,Aiba Yoshihiro,Komori Atsumasa,Nakamura Minoru,Motokawa Satoru,Kawakami Atsushi,Nakamura Tadashi,Ishibashi Hiromi
- Arthritis Research & Therapy 14(3), R119, 2012-05-18
- … Background: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1β (IL-1β) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. … The cellular supernatants were analyzed by immunoblotting using anti-IL-1β or anti-caspase-1 antibodies. …
- NAID 120004680717
- Analysis of candidate genes of spontaneous arthritis in mice deficient for interleukin-1 receptor antagonist
- CAO Yanhong,LI Caijuan,YAN Jian,JIAO Feng,LIU XiaoYun,HASTY Karen A.,STUART John M.,GU Weikuan,JIAO Yan
- Genes & genetic systems 87(2), 107-113, 2012-04-25
- NAID 10030616593
Related Pictures
★リンクテーブル★
[★]
- 関
- IL1 receptor、interleukin-1 receptor
[★]
- 英
- interleukin-1 receptor、IL-1 receptor
- 関
- インターロイキン1レセプター、IL-1受容体、IL-1レセプター
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- 英
- interleukin-1 receptor、IL-1 receptor
- 関
- インターロイキン1受容体、IL-1受容体、IL-1レセプター
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インターロイキン IL
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インターロイキン IL