WordNet

subject to change; variable; "a fluid situation fraught with uncertainty"; "everything was unstable following the coup" (同)unstable
a substance that is fluid at room temperature and pressure
continuous amorphous matter that tends to flow and to conform to the outline of its container: a liquid or a gas
in cash or easily convertible to cash; "liquid (or fluid) assets" (同)liquid
affording change (especially in social status); "Britain is not a truly fluid society"; "upwardly mobile" (同)mobile
characteristic of a fluid; capable of flowing and easily changing shape (同)runny
located between cells

PrepTutorEJDIC

『流体』,流動体 / 『流動性の』,流動する / 流体の,流動体から成る / 変わりやすい,固定していない,浮動する
細胞間の,細胞間にある
インフルエンザ,流感

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 05:47:26」(JST)

wiki en

[Wiki en表示]

Interstitial fluid or tissue fluid is a solution that bathes and surrounds the tissue cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid. The interstitial fluid is found in the interstitial spaces (also known as the tissue spaces) - the spaces between cells.

On average, a person has about 10 litres (2.4 imperial gallons or ~2.9 US gal) of interstitial fluid (they make up 16% of the total body weight), providing the cells of the body with nutrients and a means of waste removal.

Production and removal

Plasma and interstitial fluid are very similar. This similarity exists because water, ions, and small solutes are continuously exchanged between plasma and interstitial fluids across the walls of capillaries. Plasma, the major component in blood, communicates freely with interstitial fluid through pores and intercellular clefts in capillary endothelium.

Formation

Hydrostatic pressure is generated by the systolic force of the heart. It pushes water out of the capillaries.

The water potential is created due to the inability of certain blood proteins (mostly serum albumin) to pass through the walls of capillaries. The buildup of these proteins within the capillaries induces osmosis. The water passes from a high concentration (of water) outside of the vessels to a low concentration inside of the vessels, in an attempt to reach an equilibrium. The osmotic pressure drives water back into the vessels. Because the blood in the capillaries is constantly flowing, equilibrium is never reached.

The balance between the two forces differs at different points on the capillaries. At the arterial end of a vessel, the hydrostatic pressure is greater than the osmotic pressure, so the net movement (see net flux) favors water and other solutes being passed into the tissue fluid. At the venous end, the osmotic pressure is greater, so the net movement favors substances being passed back into the capillary. This difference is created by the direction of the flow of blood and the imbalance in solutes created by the net movement of water favoring the tissue fluid.

Removal

To prevent a buildup of tissue fluid surrounding the cells in the tissue, complementing the venous system is the lymphatic system, which plays a part in the transport of tissue fluid. Tissue fluid can pass into the surrounding lymph vessels, and eventually ends up rejoining the blood.

Sometimes the removal of tissue fluid does not function correctly, and there is a build-up. This can cause swelling, often around the feet and ankles, which is generally known as oedema. The position of swelling is due to the effects of gravity.

Composition

Interstitial fluid consists of a water solvent containing sugars, salts, fatty acids, amino acids, coenzymes, hormones, neurotransmitters, as well as waste products from the cells.

The composition of tissue fluid depends upon the exchanges between the cells in the biological tissue and the blood. This means that tissue fluid has a different composition in different tissues and in different areas of the body.

Not all of the contents of the blood pass into the tissue, which means that tissue fluid and blood are not the same. Red blood cells, platelets, and plasma proteins cannot pass through the walls of the capillaries. The resulting mixture that does pass through is, in essence, blood plasma without the plasma proteins. Tissue fluid also contains some types of white blood cell, which help combat infection.

Lymph is considered to be extracellular fluid until it enters the lymphatic vessels where it is then considered to be lymph. The lymphatic system returns protein and excess interstitial fluid to the circulation.

The ionic composition of the interstitial fluid and blood plasma vary due to the Gibbs–Donnan effect. This causes a slight difference in the concentration of cations and anions between the two fluid compartments.

Physiological function

Interstitial fluid bathes the cells of the tissues. This provides a means of delivering materials to the cells, intercellular communication, as well as removal of metabolic waste.

Structure of the lymphatic system

The lymphatic system is a collection system which starts in the same tissue space as initial lymph collectors that have fenestrated openings to allow fluid and particles to enter. These initial lymph collectors are valveless vessels and go on to form the precollector vessels which have rudimentary valves which are not considered to be fully functional. These structures then form increasingly larger lymphatic vessels, which form co-laterals. In animals lower than mammals, these vessels have lymph hearts, which possess stretch receptors and smooth muscle tissue embedded in their walls. The lymphatic vessels make their way to the lymph nodes and from the lymph nodes the vessels form into trunks which connect to the internal jugular group of veins in the neck. The lymphatic system, once thought to be passive, is now known to be an active pumping system, with segments exhibiting a function similar to that of peristalsis.

References

Marieb, Elaine N. (2003). Essentials of Human Anatomy & Physiology (Seventh ed.). San Francisco: Benjamin Cummings. ISBN 0-8053-5385-2.

External links

"Interstitial fluid" at Dorland's Medical Dictionary

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 術後の成人患者に行う輸液療法の概要 overview of postoperative fluid therapy in adults
2. 術中の輸液マネージメント intraoperative fluid management
3. 術後に生じる電解質異常の概要 overview of postoperative electrolyte abnormalities
4. 成人における維持輸液療法および補充輸液療法 maintenance and replacement fluid therapy in adults
5. 小児における維持輸液療法 maintenance fluid therapy in children

English Journal

VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production.

Tsai YY1, Rainey WE1, Johnson MH2, Bollag WB3.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Sep 15;433:138-46. doi: 10.1016/j.mce.2016.05.018. Epub 2016 May 21.
Aldosterone plays an important role in regulating ion and fluid homeostasis and thus blood pressure, and hyperaldosteronism results in hypertension. Hypertension is also observed with obesity, which is associated with additional health risks, including cardiovascular disease. Obese individuals have
PMID 27222295

Adhesion kinetics of human primary monocytes, dendritic cells, and macrophages: Dynamic cell adhesion measurements with a label-free optical biosensor and their comparison with end-point assays.

Orgovan N1, Ungai-Salánki R2, Lukácsi S3, Sándor N4, Bajtay Z3, Erdei A5, Szabó B1, Horvath R6.
Biointerphases.Biointerphases.2016 Sep 1;11(3):031001. doi: 10.1116/1.4954789.
Monocytes, dendritic cells (DCs), and macrophages (MFs) are closely related immune cells that differ in their main functions. These specific functions are, to a considerable degree, determined by the differences in the adhesion behavior of the cells. To study the inherently and essentially dynamic a
PMID 27368161

Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema.

Hadamitzky C1, Zaitseva TS2, Bazalova-Carter M3, Paukshto MV2, Hou L4, Strassberg Z5, Ferguson J6, Matsuura Y7, Dash R7, Yang PC7, Kretchetov S8, Vogt PM9, Rockson SG7, Cooke JP10, Huang NF11.
Biomaterials.Biomaterials.2016 Sep;102:259-67. doi: 10.1016/j.biomaterials.2016.05.040. Epub 2016 Jun 7.
Secondary lymphedema is a common disorder associated with acquired functional impairment of the lymphatic system. The goal of this study was to evaluate the therapeutic efficacy of aligned nanofibrillar collagen scaffolds (BioBridge) positioned across the area of lymphatic obstruction in guiding lym
PMID 27348849