insulin glulisine

WordNet

1. hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells

PrepTutorEJDIC

1. インシュリン(膵臓(すいぞう)ホルモンで糖尿病治療剤)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/10 10:24:41」(JST)

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Insulin glulisine

Clinical data
Trade names	Apidra
AHFS/Drugs.com	Monograph
MedlinePlus	a607033
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Subcutaneous
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Identifiers
CAS Number	207748-29-6 N
ATC code	A10AB06 (WHO)
DrugBank	DB01309 Y
ChemSpider	none
UNII	7XIY785AZD N
KEGG	D04540 Y
Chemical data
Formula	C258H384N64O78S6
Molar mass	5823 g/mol
NY (what is this?)  (verify)

Insulin glulisine is a rapid-acting insulin analogue that differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid. It was developed by Sanofi-Aventis and sold under the trade name Apidra. When injected subcutaneously, it appears in the blood earlier than human insulin. When used as a meal time insulin, the dose is given within 15 minutes before a meal or within 20 minutes after starting a meal. Intravenous injections may also be used for extreme hyperglycemia, but must be performed under the supervision of a medical professional.

References

External links

• Apidra Homepage

UpToDate Contents

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• 1. 2型糖尿病におけるインスリン療法 insulin therapy in type 2 diabetes mellitus
• 2. 糖尿病におけるインスリン療法の一般原則 general principles of insulin therapy in diabetes mellitus
• 3. 成人の1型糖尿病における血糖値マネージメント management of blood glucose in adults with type 1 diabetes mellitus
• 4. 成人における糖尿病性ケトアシドーシスおよび高浸透圧性高血糖状態：治療 diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults treatment
• 5. 糖尿病に対する強化インスリン療法に関する問題についての症例 cases illustrating problems with intensive insulin therapy for diabetes mellitus

English Journal

• Efficacy of Adding Once-Daily Insulin Glulisine in Japanese Type 2 Diabetes Patients Treated with Insulin Glargine and Sitagliptin.

• Takahara M1, Shiraiwa T, Katakami N, Matsuoka TA, Shimomura I.
• Diabetes technology & therapeutics.Diabetes Technol Ther.2014 Jun 20. [Epub ahead of print]
• Abstract Background: Glucose fluctuation often remains to be corrected under basal-supported oral therapy. We investigated the efficacy of adding once-daily rapid-acting insulin in Japanese diabetes patients treated with basal-supported oral therapy. Subjects and Methods: In this 8-week, parallel-gr
• PMID 24949654

• Greater hypoglycemia fear with premixed insulin than basal-bolus insulin glargine and glulisine: patient-reported outcomes from a 60-week randomized study.

• Polonsky WH1, Thompson S, Wei W, Riddle MC, Chaudhari S, Jackson J, Bruno AS.
• Diabetes, obesity & metabolism.Diabetes Obes Metab.2014 Jun 12. doi: 10.1111/dom.12328. [Epub ahead of print]
• AIM: To assess the effect of initiating insulin on quality of life (QoL) of patients with type 2 diabetes (T2DM) in the 60-week All-to-Target trial (NCT00384085).METHODS: Patient-reported outcomes (PROs) from the phase 4, multicenter, randomized, open-label, parallel-group study were analyzed. Parti
• PMID 24919603

• Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature.

• Teska BM1, Alarcón J, Pettis RJ, Randolph TW, Carpenter JF.
• Journal of pharmaceutical sciences.J Pharm Sci.2014 Jun 6. doi: 10.1002/jps.24039. [Epub ahead of print]
• The stability of three commercial "fast-acting" insulin analogs, insulin lispro, insulin aspart, and insulin glulisine, was studied at various concentrations of phenolic preservatives (phenol and/or meta-cresol) during 9 days of incubation at 37°C. The analysis by both size-exclusion and reversed-p
• PMID 24909933

Japanese Journal

• インスリングルリジンによるインスリン持続皮下注入療法を導入した1型糖尿病患者への薬剤師の介入

• 浅井 佑太,小岩 正二,工藤 陽一 [他]
• 交通医学 65(5・6), 121-127, 2011-11
• NAID 40019318600

• 経口血糖降下薬+持効型インスリン製剤併用療法にても効果不十分な2型糖尿病患者におけるインスリングルリジン1日1回追加療法の有用性について : 血糖コントロールおよびQOLに及ぼす影響

• 新谷 哲司,橋本 明子,堀見 史奈子,西山 麻里,関川 孝司,古川 慎哉
• 糖尿病 53(9), 675-679, 2010-09-30
• NAID 10026912491

Related Links

• Fast-Acting, Mealtime Insulin | Apidra® (insulin glulisine [rDNA ...

Apidra® is a fast acting, mealtime insulin used to help maintain blood sugar control for adults with type 1 and adults and pediatric (4 years and older) patients with type 2 diabetes.

• Insulin Glulisine (rDNA origin) Injection: MedlinePlus Drug ...

Insulin glulisine comes as a solution (liquid) to inject subcutaneously (under the skin). It is usually injected up to 15 minutes before a meal or within 20 minutes after starting a meal. Follow the directions on your prescription label ...

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リンク元	「インスリングルリジン」

「インスリングルリジン」

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