WordNet

in an inefficient manner; "he dealt inefficiently with the crisis"
not producing desired results; wasteful; "an inefficient campaign against drugs"; "outdated and inefficient design and methods"

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Treatment switching in oncology trials and the acceptability of adjustment methods.

Latimer NR1.
Expert review of pharmacoeconomics & outcomes research.Expert Rev Pharmacoecon Outcomes Res.2015 Aug;15(4):561-4. doi: 10.1586/14737167.2015.1037835. Epub 2015 Apr 20.
Treatment switching has become an important issue in the development and approval of new drugs, particularly in oncology. Randomized controlled trials (RCTs) represent the gold standard for evaluating the effectiveness of interventions, but often patients randomized to the control group are permitte
PMID 25893990

Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.

Chen D1, Nicholas J2.
Journal of virology.J Virol.2015 Aug 1;89(15):7979-90. doi: 10.1128/JVI.00375-15. Epub 2015 May 27.
The interleukin-6 homologue (viral interleukin-6 [vIL-6]) of human herpesvirus 8 is implicated in viral pathogenesis due to its proproliferative, inflammatory, and angiogenic properties, effected through gp130 receptor signaling. In primary effusion lymphoma (PEL) cells, vIL-6 is expressed latently
PMID 26018151

L-type Calcium Channel Blockers Enhance Trafficking and Function of Epilepsy-associated α1(D219N) Subunits of GABAA Receptors.

Han DY1, Guan BJ1, Wang YJ1, Hatzoglou M1, Mu TW1.
ACS chemical biology.ACS Chem Biol.2015 Jul 21. [Epub ahead of print]
Gamma-aminobutyric acid type A (GABAA) receptors are the primary inhibitory ion channels in the mammalian central nervous system and play an essential role in regulating inhibition-excitation balance in neural circuits. The α1 subunit harboring the D219N mutation of GABAA receptors was reported to
PMID 26168288

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

Suzuki Jun,Denning Daniel P,Imanishi Eiichi,Horvitz H Robert,Nagata Shigekazu
Science, 2013-07-11
… Mouse Xkr8(-/-) cells or human cancer cells in which Xkr8 expression was repressed by hypermethylation failed to expose PtdSer during apoptosis and were inefficiently engulfed by phagocytes. …
NAID 120005300357

Analysis and Enhancement of an Optimized Gateway-Oriented Password-Based Authenticated Key Exchange Protocol

WEI Fushan,ZHANG Zhenfeng,MA Chuangui
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E96.A(9), 1864-1871, 2013
… In this paper, we point out that Yoon et al.'s gateway-oriented password-based authenticated key exchange (GPAKE) protocol is inefficiently and incorrectly designed to overcome the undetectable on-line dictionary attack. …
NAID 130003370728

KO Nam-Seok,HEO Hwanjo,PARK Jong-Dae,PARK Hong-Shik
IEICE Transactions on Communications E96.B(2), 479-488, 2013
… OpenQFlow provides a fine-grained flow tracking while flow classification is decoupled from the tracking by separating the inefficiently coupled flow table to three different tables: flow state table, forwarding rule table, and QoS rule table. …
NAID 130003370083