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- immunoadjuvant、immunologic adjuvant、immunological adjuvant、immunostimulant
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/16 22:13:07」(JST)
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Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by inducing activation or increasing activity of any of its components. One notable example is the granulocyte macrophage colony-stimulating factor.
Contents
- 1 Classification
- 2 See also
- 2.1 General
- 2.2 Endogenous immunostimulants
- 2.3 Synthetic immunostimulants
- 3 References
- 4 External links
Classification
There are two main categories of immunostimulants:[1]
- Specific immunostimulants provide antigenic specificity in immune response, such as vaccines or any antigen.
- Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response of other antigen or stimulate components of the immune system without antigenic specificity, such as adjuvants and non-specific immunostimulators.
Non-specific
Many endogenous substances are non-specific immunostimulators. For example, female sex hormones are known to stimulate both adaptive[2] and innate immune responses.[3] Some autoimmune diseases such as lupus erythematosus strike women preferentially, and their onset often coincides with puberty. Other hormones appear to regulate the immune system as well, most notably prolactin, growth hormone and vitamin D.[4][5]
Some publications point towards the effect of deoxycholic acid (DCA) as an immunostimulant[6][7][8] of the non-specific immune system, activating its main actors, the macrophages. According to these publications, a sufficient amount of DCA in the human body corresponds to a good immune reaction of the non-specific immune system.
See also
General
- Antigen
- Co-stimulation
- Immunogenicity
- Immunologic adjuvant
- Immunomodulator
- Immunotherapy
Endogenous immunostimulants
- Deoxycholic acid, a stimulator of macrophages
Synthetic immunostimulants
- Imiquimod and resiquimod, activate immune cells through the toll-like receptor 7
References
- ^ Kumar, S; Gupta P; Sharma S; Kumar D (2011). "A review on immunostimulatory plants". Journal of Chinese Integrative Medicine 9 (2): 117–128. doi:10.3736/jcim20110201. PMID 21288444.
- ^ Wira, CR; Crane-Godreau M; Grant K (2004). "Endocrine regulation of the mucosal immune system in the female reproductive tract". In In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J (eds.). Mucosal Immunology. San Francisco: Elsevier. ISBN 0-12-491543-4.
- ^ Lang, TJ (2004). "Estrogen as an immunomodulator". Clin Immunol 113 (3): 224–230. doi:10.1016/j.clim.2004.05.011. PMID 15507385.
Moriyama, A; Shimoya K; Ogata I; et al. (1999). "Secretory leukocyte protease inhibitor (SLPI) concentrations in cervical mucus of women with normal menstrual cycle". Molecular Human Reproduction 5 (7): 656–661. doi:10.1093/molehr/5.7.656. PMID 10381821.
Cutolo, M; Sulli A; Capellino S; Villaggio B; Montagna P; Seriolo B; Straub RH (2004). "Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity". Lupus 13 (9): 635–638. doi:10.1191/0961203304lu1094oa. PMID 15485092.
King, AE; Critchley HOD; Kelly RW (2000). "Presence of secretory leukocyte protease inhibitor in human endometrium and first trimester decidua suggests an antibacterial role". Molecular Human Reproduction 6 (2): 191–196. doi:10.1093/molehr/6.2.191. PMID 10655462.
- ^ Dorshkind, K; Horseman ND (2000). "The Roles of Prolactin, Growth Hormone, Insulin-Like Growth Factor-I, and Thyroid Hormones in Lymphocyte Development and Function: Insights from Genetic Models of Hormones and Hormone Receptor Deficiency". Endocrine Reviews 21 (3): 292–312. doi:10.1210/er.21.3.292. PMID 10857555.
- ^ Nagpal, Sunil; Songqing Naand; Radhakrishnan Rathnachalam (2005). "Noncalcemic Actions of Vitamin D Receptor Ligands". Endocrine Reviews 26 (5): 662–687. doi:10.1210/er.2004-0002. PMID 15798098.
- ^ Vlcek, B; Reif, A; Seidlová, B (1971). "Evidence of the participation of deoxycholate in cancer immunity". Zeitschrift für Naturforschung B 26 (5): 419–24. PMID 4398280.
- ^ Vlček, B (1972). "Potentiation of the immune response with DCA". Prakt. Lekar (in Czech) 52: 326–330.
- ^ Chyle, M; Chyle, P (1982). "Regulation of the immune response with DCA". Sbornik lek. (in Czech) 84: 212–218. (English summary)
External links
- Veterinary Immunology and Immunopathology journal
- Immunostimulants at the US National Library of Medicine Medical Subject Headings (MeSH)
- Deoxycholic acid as immunostimulant
Immunostimulants (L03)
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Endogenous |
Cytokines |
Colony-stimulating factors |
- G-CSF
- Filgrastim / Pegfilgrastim
- Lenograstim
- GM-CSF
- Molgramostim
- Sargramostim
- SCF
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Interferons |
- alpha:
- Albinterferon
- Interferon alfa natural
- Interferon alfa 2a / Peginterferon alfa-2a
- Interferon alfa 2b / Peginterferon alfa-2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- beta:
- Interferon beta natural
- Interferon beta 1a
- Interferon beta 1b
- Interferon gamma
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Interleukins |
|
|
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Other protein / peptide |
- Growth hormone
- Immunocyanin
- Pegademase
- Prolactin
- Tasonermin
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Other |
- Female sex steroids
- Histamine dihydrochloride
- Poly ICLC
- Vitamin D
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Exogenous |
- beta-glucan
- heterocyclic compound
- hydroxyquinoline
- Mifamurtide
- oligopeptides
- Glatiramer acetate
- Thymopentin
- Thymosin α1
- Thymulin
- polyribonucleotide
- Polyinosinic:polycytidylic acid
- thiazolidine
- vaccines
- Bacillus Calmette–Guérin
- Melanoma vaccine
- Sipuleucel-T
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Index of the immune system
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Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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English Journal
- Effects of selenizing angelica polysaccharide and selenizing garlic polysaccharide on immune function of murine peritoneal macrophage.
- Gao Z1, Liu K1, Tian W1, Wang H1, Liu Z1, Li Y1, Li E1, Liu C1, Li X1, Hou R1, Yue C1, Wang D1, Hu Y2.
- International immunopharmacology.Int Immunopharmacol.2015 Jul;27(1):104-9. doi: 10.1016/j.intimp.2015.04.052. Epub 2015 May 8.
- The effects of two selenizing polysaccharides (sCAP2 and sGPS6) on immune function of murine peritoneal macrophages taking two non-selenizing polysaccharides (CAP and GPS) and modifier Na2SeO3 as control. In vitro test, the changes of selenizing polysaccharides, non-selenizing polysaccharides and Na
- PMID 25962819
- A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo.
- Cirillo N1, Vicidomini A, McCullough M, Gambardella A, Hassona Y, Prime SS, Colella G.
- Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1421-9. doi: 10.1002/jcp.24908.
- Virtually all patients receiving radio- and chemotherapy for cancer develop oral mucositis, a severe and highly debilitating condition. The onset of mucositis is thought to involve the production of reactive oxygen species (ROS) in the submucosa. Here we investigated a possible protective effect of
- PMID 25536474
- Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte.
- Jiang L1, Dasgupta I1, Hurcombe JA1, Colyer HF1, Mathieson PW1, Welsh GI1.
- Clinical science (London, England : 1979).Clin Sci (Lond).2015 Jun;128(12):883-93. doi: 10.1042/CS20140749.
- Minimal change nephropathy (MCN) is the third most common cause of primary nephrotic syndrome in adults. Most patients with MCN respond to corticosteroid therapy, but relapse is common. In children, steroid-dependent patients are often given alternative agents to spare the use of steroids and to avo
- PMID 25626449
Japanese Journal
- 口腔癌に対する樹状細胞ワクチン療法 : 基礎から臨床へ
- 岡本 正人
- 日本口腔腫瘍学会誌 23(4), 123-127, 2011-12-15
- 標準治療に抵抗性を示す難治性の悪性腫瘍に対し,専門的抗原提示細胞である樹状細胞(DC)を用いた癌ワクチン(DCワクチン)が注目されている。DCワクチンでは,第1に,品質の良いDCを大量に,安定的に作製するシステムが必要である。特に,適切な成熟DCの誘導法の確立は重要である。われわれは,レンサ球菌由来免疫賦活剤OK-432の活性成分が,Toll-like receptorsを介してDCを成熟させ,抗 …
- NAID 10030796050
- Immunopotentiator from Pantoea agglomerans 1 (IP-PA1)は経口投与によりメラノーマ担癌マウスの生存を改善する
- 蛇島 武久,松本 安喜,渡辺 元 [他],SOMA Gen-ichiro,KOHCHI Chie,TAYA Kazuyoshi,HAYASHI Yoshihiro,HIROTA Yoshikazu
- Experimental animals 60(2), 101-109, 2011-04-01
- … To investigate the usefulness of the immunopotentiator from Pantoea agglomerans 1 (IP-PA1) as a supportive drug in melanoma therapy, we analyzed the immunological effects of IP-PA1 on melanoma-inoculated model mice. …
- NAID 10029550117
- たいまつ米胚芽発酵GABAによるヒト単球系細胞株(U937)表面上のCD93の発現およびインターロイキンー 8(IL-8)の産生増強
- 池脇 信直,石附 亨,中村 雅彦 [他],林 裕二,樋口 元剛,後藤 牧人
- 九州保健福祉大学研究紀要 11, 159-167, 2010-03
- たいまつ米胚芽発酵GABAによる単球系細胞株(U937)表面上のCD93抗原の発現をモノクローナル抗体を用いた酵素抗体法およびフローサイトメトリー法で解析した。その結果、たいまつ米胚芽発酵GABAで培養したU937細胞はCD93(C1qRp)の発現が有意に増強した。また、CD93の発現増強はprotein kinase C(PKC)阻害剤であるGo6976で抑制された。さらに、たいまつ米胚芽発酵G …
- NAID 110007577976
Related Links
- immunopotentiator im·mu·no·po·ten·ti·a·tor (ĭm'yə-nō-pə-těn'shē-ā'tər, ĭ-myōō'-) n. An agent that on inoculation enhances the immune response.
- NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that the company will make presentations at two scientific conferences: Immunopotentiators ...
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免疫アジュバント、免疫学的アジュバント
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- immunoadjuvant、immunologic adjuvant、immunopotentiator、immunostimulant
[★]
- 英
- immunostimulant、immunopotentiator
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- 免疫増強剤、免疫アジュバント、免疫学的アジュバント
[★]
免疫アジュバント
- 関
- immunoadjuvant、immunological adjuvant、immunopotentiator、immunostimulant
[★]
- 関
- immunologic adjuvant、immunological adjuvant、immunopotentiator、immunostimulant
[★]
- 関
- immunoadjuvant、immunologic adjuvant、immunological adjuvant、immunopotentiator