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English Journal

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

Hamon Y1, Legowska M2, Hervé V3, Dallet-Choisy S3, Marchand-Adam S3, Vanderlynden L3, Demonte M3, Williams R4, Scott CJ4, Si-Tahar M3, Heuzé-Vourc'h N3, Lalmanach G3, Jenne DE5, Lesner A2, Gauthier F3, Korkmaz B6.
The Journal of biological chemistry.J Biol Chem.2016 Apr 15;291(16):8486-99. doi: 10.1074/jbc.M115.707109. Epub 2016 Feb 16.
The cysteine protease cathepsin C (CatC) activates granule-associated proinflammatory serine proteases in hematopoietic precursor cells. Its early inhibition in the bone marrow is regarded as a new therapeutic strategy for treating proteolysis-driven chronic inflammatory diseases, but its complete i
PMID 26884336

Radiation dose determines the method for quantification of DNA double strand breaks.

Bulat T1, Keta O1, Korićanac L1, Žakula J1, Petrović I1, Ristić-Fira A1, Todorović D2.
Anais da Academia Brasileira de Ciências.An Acad Bras Cienc.2016 Mar;88(1):127-36. doi: 10.1590/0001-3765201620140553. Epub 2016 Mar 4.
Ionizing radiation induces DNA double strand breaks (DSBs) that trigger phosphorylation of the histone protein H2AX (γH2AX). Immunofluorescent staining visualizes formation of γH2AX foci, allowing their quantification. This method, as opposed to Western blot assay and Flow cytometry, provides more
PMID 26959322

Apoptosis of conjunctival epithelial cells before and after the application of autologous serum eye drops in severe dry eye disease.

Rybickova I1,2, Vesela V1, Fales I3, Skalicka P2, Jirsova K1.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2016 Feb 29. doi: 10.5507/bp.2016.001. [Epub ahead of print]
AIMS: To assess the impact of autologous serum eye drops on the level of ocular surface apoptosis in patients with bilateral severe dry eye disease.METHODS: This prospective study was conducted on 10 patients with severe dry eye due to graft versus host disease (group 1) and 6 patients with severe d
PMID 26927466

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 88, 81-85, 2014-06
NAID 120005456018

A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells