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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/13 19:23:40」(JST)

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Hypotrichosis (hypo- + tricho- + -osis) is a condition of abnormal hair patterns - predominantly loss or reduction. It occurs, most frequently, by the growth of vellus hair in areas of the body that normally produce terminal hair. Typically, the individual's hair growth is normal after birth, but shortly thereafter the hair is shed and replaced with sparse, abnormal hair growth. The new hair is typically fine, short and brittle, and may lack pigmentation. Baldness may be present by the time the subject is 25 years old.^[1]

Hypotrichosis is a common feature of Hallermann–Streiff syndrome as well as others. It can also be used to describe the lack of hair growth due to chemotherapy.

The opposite of hypotrichosis is hypertrichosis, where terminal hair (thick) grows in areas that would otherwise normally have vellus hair (thin), for example abnormally thick facial hair growth in women.

Genetic forms of localized autosomal recessive hypotrichosis include:

Type	OMIM	Gene	Locus
LAH1	607903	DSG4	18q12
LAH2	604379	LIPH	3q27
LAH3	611452	P2RY5	13q14.12-q14.2

References

^ Dawber, Rodney P. R.; Van Neste, Dominique (2004). Hair and scalp disorders: common presenting signs, differential diagnosis and treatment (2nd ed.). Informa Health Care. pp. 53–54. ISBN 1-84184-193-5.

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1. 脱毛の評価および診断 evaluation and diagnosis of hair loss

English Journal

Comprehensive dental management in a Hallermann-Streiff syndrome patient with unusual radiographic appearance of teeth.

Gungor OE, Nur BG, Yalcin H, Karayilmaz H1, Mihchi E.
Nigerian journal of clinical practice.Niger J Clin Pract.2015 Jul-Aug;18(4):559-62. doi: 10.4103/1119-3077.156910.
Hallermann-Streiff syndrome (HSS) is a genetic disorder characterized by proportionate dwarfism, birdlike facies, hypotrichosis, skin atrophy, dyscephaly, bilateral microphthalmia, congenital cataracts, a narrow, weak, beaked nose, a hypoplastic mandible, and orodental anomalies. Occurrence is spora
PMID 25966733

Recurrent duplication mutation in HRAS causing mild Costello syndrome in a Chinese patient.

Xu F1, Wang HJ2,3, Lin ZM2, Yu B1.
Clinical and experimental dermatology.Clin Exp Dermatol.2015 Jun;40(4):404-7. doi: 10.1111/ced.12571. Epub 2015 Feb 10.
Costello syndrome (CS; OMIM 218040) is caused by heterozygous germline mutations of HRAS (OMIM 190020).We report on a patient with sporadic CS presenting with characteristic craniofacial dysmorphism, congenital cardiopulmonary disorders, intellectual impairment, and skin abnormalities manifesting as
PMID 25677562

Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6.

Hayashi R1, Inoue A2, Suga Y3, Aoki J4, Shimomura Y5.
Journal of dermatological science.J Dermatol Sci.2015 Jun;78(3):197-205. doi: 10.1016/j.jdermsci.2015.03.006. Epub 2015 Mar 18.
BACKGROUND: Woolly hair (WH) is a hair shaft anomaly characterized by tightly-curled hair and is frequently associated with hypotrichosis. Non-syndromic forms of WH can show either autosomal dominant or recessive inheritance. The autosomal recessive form of WH (ARWH) is caused by mutations in either
PMID 25828854