WordNet

abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues

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Adenylyl Cyclase 6 Enhances NKCC2 Expression and Mediates Vasopressin-Induced Phosphorylation of NKCC2 and NCC.

Rieg T, Tang T, Uchida S, Hammond HK, Fenton RA, Vallon V.SourceDepartment of Medicine, University of California San Diego, La Jolla, California; VA San Diego Healthcare System, San Diego, California. Electronic address: trieg@ucsd.edu.
The American journal of pathology.Am J Pathol.2013 Jan;182(1):96-106. doi: 10.1016/j.ajpath.2012.09.014. Epub 2012 Nov 1.
Arginine vasopressin (AVP) affects kidney function via vasopressin V(2) receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosine monophosphate formation. AVP/cyclic adenosine monophosphate enhance the phosphorylation of the Na-K-2Cl cotransporter (NKCC2) a
PMID 23123217

Multiple Evolutionarily Conserved Di-leucine Like Motifs in the Carboxyl Terminus Control the Anterograde Trafficking of NKCC2.

Zaarour N, Demaretz S, Defontaine N, Zhu Y, Laghmani K.SourceFrom the INSERM, Centre de Recherche des Cordeliers, UMRS872, Paris, France. CNRS, ERL7226, 75006 Paris, France.
The Journal of biological chemistry.J Biol Chem.2012 Dec 14;287(51):42642-53. doi: 10.1074/jbc.M112.399162. Epub 2012 Oct 26.
Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome, a life-threatening kidney disease. Yet the mechanisms underlying the regulation of NKCC2 trafficking in renal cells are scarcely known. We previously showed that naturally occurring mutations depriving NKCC2 of it
PMID 23105100

Bartter syndrome type III and congenital anomalies of the kidney and urinary tract: an antenatal presentation.

Westland R, Hack WW, van der Horst HJ, Uittenbogaard LB, van Hagen JM, van der Valk P, Kamsteeg EJ, van den Heuvel LP, van Wijk JA.SourceDepartment of Pediatric Nephrology, VU University Medical Center, Amsterdam, The Netherlands. r.westland@vumc.nl
Clinical nephrology.Clin Nephrol.2012 Dec;78(6):492-6.
Bartter syndrome encompasses a variety of inheritable renal tubular transport disorders characterized by hypokalemia and hypochloremic metabolic alkalosis. Bartter syndrome Type III is caused by genetic alterations in the chloride channel kidney B (CLCNKB) gene and often presents in the first 2 year
PMID 23164417

Maeda Yoshitaka,Kojima Naoki,Araki Yuya,Uno Tomomi,Nishigaki Keisuke,Inaba Naoto
Internal Medicine 50(9), 1045-1050, 2011
… We encountered two hypokalemic cases receiving omeprazole. … However, in extreme alkalosis or impaired K+-recycling system, PPIs may cause hypokalemia unrelated to hypomagnesemia. …
NAID 130000650110

関: pancreatic cholera、Verner-Morrison syndrome、VIPoma、VIPoma syndrome、watery diarrhea syndrome、watery diarrhea、hypokalemia and achlorhydria、WDHA