hypoestrogenism

低エストロゲン症

In the ovary, PRL blocks folliculogenesis and inhibits granulosa cell aromatase activity, leading to hypoestrogenism and anovulation.(HIM.2204)

WordNet

1. the absence of ovulation due to immaturity or post-maturity or pregnancy or oral contraceptive pills or dysfunction of the ovary

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/13 19:31:15」(JST)

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Hypoestrogenism
Classification and external resources
ICD-9	256.3

Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen, the primary sex hormone for women. In general, lower levels of estrogen may cause differences in the breasts, genitals, urinary tract and skin.

Hypoestrogenism is most commonly found in women who are postmenopausal, have premature ovarian failure, or are suffering from amenorrhoea; however, it is also associated with hyperprolactinaemia and the use of Gonadotropin-releasing hormone analogs in treatment of endometriosis. Additionally, it has also been linked to scoliosis and young women with type 1 diabetes mellitus.

Symptoms

Presentations of depressed estrogen levels include hot flashes, headaches, and lowered libido. Reduced bone mass density leading to secondary osteoporosis and atrophic changes such as pH change in the vagina is also linked to hypoestrogenism. Low levels of estrogen can lead to dyspareunia and limited genital arousal because of changes in the four layers of the vaginal wall. Hypoestrogenism is also considered one of the major risk factors for developing uncomplicated urinary tract infections(UTI) in post menopausal women who do not take hormone replacement therapy.

Treatment

In patients under long-term therapy, small amounts of estrogens could be given back (“add-back regimen”) through estrogen cremes, estrogen rich foods and supplements to combat such side-effects and to prevent bone wastage. Though long-term patients, both male and female, tend to undergo annual DEXA scans to appraise bone density.

See also

• Hypogonadism
• Hyperestrogenism
• Hypoandrogenism
• Hypergonadism
• Hyperandrogenism
• Estrogen

References

External links

• Gonadotropin-releasing hormone agonist-induced hypoestrogenism and blood flows in cerebral arteries.

UpToDate Contents

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• 1. 原発性無月経の病因、診断、および治療 etiology diagnosis and treatment of primary amenorrhea
• 2. 閉経の臨床症状および診断 clinical manifestations and diagnosis of menopause
• 3. 膣萎縮症の臨床症状および診断 clinical manifestations and diagnosis of vaginal atrophy
• 4. 膣萎縮症の治療 treatment of vaginal atrophy
• 5. 女性における性交痛の鑑別診断 differential diagnosis of sexual pain in women

English Journal

• Management of persistent vaginitis.

• Nyirjesy P.
• Obstetrics and gynecology.Obstet Gynecol.2014 Dec;124(6):1135-46. doi: 10.1097/AOG.0000000000000551.
• With vaginitis remaining a common condition that leads women to seek care, it is not surprising that some women develop chronic vulvovaginal problems that are difficult to diagnose and treat. With a differential diagnosis that encompasses vulvar disorders and infectious and noninfectious causes of v
• PMID 25415165

• Delayed-onset of slipped capital femoral epiphysis.

• Song KS1, Lim YW, Ok IY, Lee SW.
• Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.J Orthop Sci.2014 Oct 23. [Epub ahead of print]
• BACKGROUND: Slipped capital femoral epiphysis in adults is uncommon. The purpose of this study was to report our own four cases (six hips) of slipped capital femoral epiphysis (SCFE) in adulthood and to review the cases reported in the literature. The authors attempted to investigate the various cau
• PMID 25338654

• Functional hypothalamic amenorrhea and its influence on women's health.

• Meczekalski B1, Katulski K, Czyzyk A, Podfigurna-Stopa A, Maciejewska-Jeske M.
• Journal of endocrinological investigation.J Endocrinol Invest.2014 Sep 9. [Epub ahead of print]
• INTRODUCTION: Functional hypothalamic amenorrhea (FHA) is one of the most common causes of secondary amenorrhea. There are three types of FHA: weight loss-related, stress-related, and exercise-related amenorrhea. FHA results from the aberrations in pulsatile gonadotropin-releasing hormone (GnRH) sec
• PMID 25201001

Japanese Journal

• 当科「健康維持外来」におけるホルモン補充療法施行症例についての検証

• 牧田 和也,松村 聡子,堀場 裕子 [他]
• 日本女性医学学会雑誌 19(1), 18-24, 2011-04
• NAID 40019262545

• Pathogenesis of Osteomalacia in Itai-itai Disease

• UMEMURA Takashi,WAKO Yumi
• Journal of toxicologic pathology 19(2), 69-74, 2006-06-01
• … Our animal experiments using rats and monkeys demonstrated that hypoestrogenism induced by ovariectomy enhanced Cd toxicity, and osteopenic osteomalacia and tubular nephropathy distinctive to IID could be reproduced by Cd treatment without involvement of malnutrition such as hypovitaminosis D. …
• NAID 10020340686

• Effects of Aging and Postmenopausal Hypoestrogenism on Skin Elasticity and Bone Mineral Density in Japanese Women

• SUMINO HIROYUKI,ICHIKAWA SHUICHI,ABE MASATOSHI,ENDO YUKIE,NAKAJIMA YOSHIKAZU,MINEGISHI TAKASHI,ISHIKAWA OSAMU,KURABAYASHI MASAHIKO
• Endocrine journal 51(2), 159-164, 2004-04-01
• NAID 10012888084

Related Links

• Hypoestrogenism - Wikipedia, the free encyclopedia

Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen, the primary sex hormone for women. In general, lower levels of estrogen may cause differences in the breasts, genitals, urinary tract and skin.

• Common Drugs and Medications to Treat Hypoestrogenism

WebMD provides a list of common medications used to treat Hypoestrogenism.

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