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1. 一次予防における脂質（高コレステロール血症を含む）の治療 treatment of lipids including hypercholesterolemia in primary prevention
2. 二次予防における脂質（高コレステロール血症を含む）の治療 treatment of lipids including hypercholesterolemia in secondary prevention
3. Dyslipidemia in children: Management
4. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
5. 薬剤の効きづらい高コレステロール血症の治療 treatment of drug resistant hypercholesterolemia

English Journal

Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia.

Rosales A, Alvear M, Cuevas A, Saavedra N, Zambrano T, Salazar LA.SourceCentro de Biología Molecular & Farmacogenética, Departamento de Ciencias Básicas, Facultad de Medicina, Universidad de La Frontera, Av. Francisco Salazar 01145, Casilla 54-D, Temuco, Chile.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2012 Feb 18;413(3-4):495-501. Epub 2011 Nov 19.
BACKGROUND: Statins are normally the first-line therapy for hypercholesterolemia (HC); however, the lipid-lowering response shows high interindividual variation. We investigated the effect of four polymorphisms in CYP3A4, CYP3A5 and ABCB1 genes on response to atorvastatin and CYP3A4 activity in Chil
PMID 22120734

Treatment of familial hypercholesterolemia: is there a need beyond statin therapy?

Raper A, Kolansky DM, Cuchel M.SourceInstitute of Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA, 19104, USA.
Current atherosclerosis reports.Curr Atheroscler Rep.2012 Feb;14(1):11-6.
Familial hypercholesterolemia (FH) is a genetic lipid disorder that is characterized by severely elevated cholesterol levels and premature cardiovascular disease. Both the heterozygous and homozygous forms of FH require aggressive cholesterol-lowering therapy. Statins alone frequently do not lower t
PMID 22135161

Japanese Journal

平成5年と平成20年の15年間における建設労働者の生活習慣病有病率の変化:－肥満度・血圧・血清脂質・血糖値・尿酸値・脂肪肝－

総合健診 39(5), 567-574, 2012
NAID 130004562598

ラクナ梗塞患者における冠動脈カテーテルインターベンションが必要であった無症候性冠動脈疾患の有病率

脳卒中 34(5), 298-303, 2012
NAID 130004543259

くも膜下出血で発症した頭蓋内前脊髄動脈瘤の1例

脳卒中の外科 40(2), 135-139, 2012
NAID 130004479819

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