ヒドロキシグルタル酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/19 15:37:43」(JST)
[Wiki en表示]
α-Hydroxyglutaric acid |
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IUPAC name
2-Hydroxypentanedioic acid
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Identifiers |
CAS number |
2889-31-8 |
PubChem |
43 |
ChemSpider |
42 Y |
KEGG |
C02630 Y |
MeSH |
Alpha-hydroxyglutarate |
ChEBI |
CHEBI:17084 Y |
Jmol-3D images |
Image 1
Image 2 |
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C(CC(=O)O)C(C(=O)O)O
O=C(O)C(O)CCC(=O)O
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InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) Y
Key: HWXBTNAVRSUOJR-UHFFFAOYSA-N Y
InChI=1/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)
Key: HWXBTNAVRSUOJR-UHFFFAOYAI
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Properties |
Molecular formula |
C5H8O5 |
Molar mass |
148.11 g mol−1 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Y (verify) (what is: Y/N?) |
Infobox references |
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α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.
UpToDate Contents
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English Journal
- IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells.
- Matsunaga H, Futakuchi-Tsuchida A, Takahashi M, Ishikawa T, Tsuji M, Ando O.SourceOncology Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2012 Jul 6;423(3):553-6. Epub 2012 Jun 7.
- D-2-hydroxyglutaric aciduria (D-2HGA) is a hereditary metabolic disorder characterized by the elevated levels of D-2-hydroxyglutaric acid (D-2HG) in urine, plasma and cerebrospinal fluid. About half of the patients have autosomal recessive mutations in D-2-hydroxyglutarate dehydrogenase (D2HGDH) gen
- PMID 22683334
- Glutaric acidemia Type 1: Outcomes before and after expanded newborn screening.
- Viau K, Ernst SL, Vanzo RJ, Botto LD, Pasquali M, Longo N.SourceDepartment of Pediatrics, Division of Medical Genetics, University of Utah, 50 North Medical Drive, 2C412 SOM, Salt Lake City, UT 84132, USA.
- Molecular genetics and metabolism.Mol Genet Metab.2012 Jun 9. [Epub ahead of print]
- Glutaric acidemia type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism. Patients may present with brain atrophy, macrocephaly, and acute dystonia secondary to striatal degeneration typically triggered by an infection, fever, and/or dehydration. This di
- PMID 22728054
Japanese Journal
- Molecular characterization of urban organic aerosol in tropical India : contributions of primary emissions and secondary photooxidation
- Fu P. Q.,Kawamura K.,Pavuluri C. M.,Swaminathan T.,Chen J.
- Atmospheric Chemistry and Physics 10(6), 2663-2689, 2010-03-19
- … Di-(2-ethylhexyl) phthalate, C16 fatty acid, and levoglucosan were identified as the most abundant single compounds. … However, biogenic VOC oxidation products (e.g., 2-methyltetrols, pinic acid, 3-hydroxyglutaric acid and β-caryophyllinic acid) showed diurnal patterns with daytime maxima. … Interestingly, terephthalic acid was maximized at nighttime, which is different from those of phthalic and isophthalic acids. …
- NAID 120002678130
- Contributions of isoprene, α/β-pinene and β-caryophyllene to secondary organic aerosol in tropical India
- Fu Pingqing,河村 公隆,Pavuluri Chandra M. [他]
- 低温科学 68, 79-88, 2010
- … Most of the SOA tracers showed higher concentrations in summer than in winter, while β-caryophyllinic acid, a tracer for β-caryophyllene, showed no seasonal differences. … A good correlation (R2=0.67) was found between the concentrations of 3-hydroxyglutaric acid and 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA). …
- NAID 40018948545
Related Links
- Buy 3-Hydroxyglutaric Acid (CAS 638-18-6), a glutaric acid derivative and byproduct of Glutaric acidemia type I, from Santa Cruz. MF C5H8O5, MW 148.11 ... 3-Hydroxyglutaric Acid is a glutaric acid derivative which is the byproduct ...
- hydroxyglutaric acid /hy·droxy·glu·tar·ic ac·id/ (-gloo-tar´ik) any of several hydroxylated derivatives of glutaric acid, some of which are accumulated and ... Disclaimer All content on this website, including dictionary, thesaurus ...
★リンクテーブル★
[★]
- 英
- hydroxyglutaric acid, hydroxyglutarate
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臨床関連
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ヒドロキシグルタル酸尿症