ホーミング受容体、ホーミングレセプター
WordNet
- orienting or directing homeward or to a destination; "the homing instinct"; "a homing beacon"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 家に帰る;(ハトなどが)巣にもどる / (目的地への)誘導装置をもつ / 帰ること,帰還;(ハトなどの)帰巣性
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/13 20:37:09」(JST)
[Wiki en表示]
Lymphocyte homing receptors are cell adhesion molecules[1] which target addressins. Lymphocyte homing refers to adhesion of the circulating lymphocytes in blood to specialized endothelial cells within lymphoid organs, facilitated by diverse tissue-specific adhesion molecules on lymphocytes (homing receptors) and on endothelial cells (vascular addressins).
Free lymphocytes constantly recirculate in blood after their re-entry from lymphoid tissue, via lymphatic and thoracic ducts. This happens so that the full repertoire of antigenic specificities of lymphocytes is continuously represented throughout the body. Homing happens in tissue-specific manner—e.g. B lymphocytes migrate better to mucosa-associated lymphoid tissue (Peyer's patches), and T lymphocytes preferentially to the peripheral lymph nodes.[2]
Examples
Two well known examples are CD34 and GLYCAM-1.
See more
- B lymphocyte
- T lymphocyte
References
- ^ Lymphocyte homing receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Jutila M A (1994) Function and regulation of leukocyte homing receptors Journal of Leukocyte Biology, vol. 55, pp. 133-140.http://www.jleukbio.org/content/55/1/133.full.pdf
Membrane proteins: cell adhesion molecules
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Calcium-independent |
IgSF CAM |
- N-CAM (Myelin protein zero)
- ICAM (1, 5)
- VCAM-1
- PE-CAM
- L1-CAM
- Nectin (PVRL1, PVRL2, PVRL3)
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Calcium-dependent |
Cadherins |
Classical |
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Desmosomal |
- Desmoglein (DSG1, DSG2, DSG3, DSG4)
- Desmocollin (DSC1, DSC2, DSC3)
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Protocadherin |
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Unconventional/ungrouped |
- T-cadherin
- CDH4
- CDH5
- CDH6
- CDH8
- CDH11
- CDH12
- CDH15
- CDH16
- CDH17
- CDH9
- CDH10
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Selectins |
- E-selectin
- L-selectin
- P-selectin
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Integrins |
- LFA-1 (CD11a+CD18)
- Integrin alphaXbeta2 (CD11c+CD18)
- Macrophage-1 antigen (CD11b+CD18)
- VLA-4 (CD49d+CD29)
- Glycoprotein IIb/IIIa (ITGA2B+ITGB3)
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Other |
- Lymphocyte homing receptor: CD44
- L-selectin
- integrin (VLA-4, LFA-1)
- Carcinoembryonic antigen
- CD22
- CD24
- CD44
- CD146
- CD164
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UpToDate Contents
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English Journal
- Antitumor activity, pharmacokinetics, tumor-homing effect, and hepatotoxicity of a species cross-reactive c-Met antibody.
- Park H1, Kim D2, Son E2, Shin S2, Sa JK2, Kim SH3, Yoon Y4, Nam DH5.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2017 Dec 9;494(1-2):409-415. doi: 10.1016/j.bbrc.2017.09.061. Epub 2017 Sep 14.
- PMID 28917835
- Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women.
- Ogendi BMO1, Bakshi RK1, Sabbaj S1, Brown L1, Lee JY2, Kapil R1, Geisler WM1.
- American journal of reproductive immunology (New York, N.Y. : 1989).Am J Reprod Immunol.2017 Dec;78(6). doi: 10.1111/aji.12768. Epub 2017 Sep 26.
- PMID 28949051
- Differences between chronic lymphocytic leukaemia and small lymphocytic lymphoma cells by proteomic profiling and SNP microarray analysis.
- Tooze JA1, Hamzic E1, Willis F1, Pettengell R2.
- Cancer genetics.Cancer Genet.2017 Dec;218-219:20-38. doi: 10.1016/j.cancergen.2017.09.002. Epub 2017 Sep 12.
- PMID 29153094
Japanese Journal
- Involvement of hormones in olfactory imprinting and homing in chum salmon
- 太平洋サケの母川記銘・回帰行動の生理機構 (特集 魚類行動生理学)
- [ORIGINAL CONTRIBUTIONS]Impaired Th2 differentiation of CD4+ T cells from Rap2b knockout mice
Related Links
- Based on recent studies showing in vivo antioxidant effects of thymoquinone (TQ), the active ingredient of Nigella sativa seeds, this study aims to determine whether or not TQ can increase survival and sustain the expression of the homing receptor ...
- homing receptor An adhesion molecule on leukocytes that binds to endothelial cells in blood vessels. It is used by white blood cells to guide them to inflamed or ... Based on recent studies showing in vivo antioxidant effects of ...
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