histotoxic hypoxia

WordNet

1. oxygen deficiency causing a very strong drive to correct the deficiency

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/20 20:12:36」(JST)

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Histotoxic hypoxia (also called histoxic hypoxia) is the inability of cells to take up or utilize oxygen from the bloodstream, despite physiologically normal delivery of oxygen to such cells and tissues. Histotoxic hypoxia results from tissue poisoning, such as that caused by alcohol, narcotics, cyanide (which acts by inhibiting cytochrome oxidase), and certain other poisons like hydrogen sulfide (byproduct of sewage and used in leather tanning).

Histotoxic hypoxia refers to a reduction in ATP production by the mitochondria due to a defect in the cellular usage of oxygen. An example of histotoxic hypoxia is cyanide poisoning. There is a profound drop in tissue oxygen consumption since the reaction of oxygen with cytochrome c oxidase is blocked by the presence of cyanide. There are other chemicals that interrupt the mitochondrial electron transport chain (e.g., rotenone, antimycin A) and produce effects on tissue oxygenation similar to that of cyanide. Oxygen extraction decreases in parallel with the lower oxygen consumption, with a resulting increase in venous oxygen content and PvO2. Although cyanide stimulates the peripheral respiratory chemoreceptors, increasing the inspired oxygen fraction is not helpful, since there is already an adequate amount of oxygen which the poisoned cells cannot use.

See also

Hypoxia

References

UpToDate Contents

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• 1. 低酸素血症の酸素供給およびメカニズム oxygenation and mechanisms of hypoxemia
• 2. シアン化物中毒 cyanide poisoning
• 3. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
• 4. 酸素を備えている民間航空機での旅行 traveling with oxygen aboard commercial air carriers
• 5. 赤血球産生調節 regulation of erythropoiesis

English Journal

• Absence of hydrogen sulfide-induced hypometabolism in pigs: a mechanistic explanation in relation to small nonhibernating mammals.

• Dirkes MC1, Milstein DM, Heger M, van Gulik TM.
• European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes.Eur Surg Res.2015;54(3-4):178-91. doi: 10.1159/000369795. Epub 2015 Feb 12.
• Artificially induced hypometabolism in nonhibernating mammals may have considerable clinical implications. Numerous studies in small rodent models have demonstrated that hydrogen sulfide (H2S) induces hypometabolism, supposedly as a result of histotoxic hypoxia. However, the induction of hypometabol
• PMID 25676197

• Ataxia with Parkinsonism and dystonia after intentional inhalation of liquefied petroleum gas.

• Godani M1, Canavese F1, Migliorini S2, Sette MD1.
• Neuropsychiatric disease and treatment.Neuropsychiatr Dis Treat.2015 May 6;11:1157-9. doi: 10.2147/NDT.S80460. eCollection 2015.
• The practice of inhaling liquefied petroleum gas (LPG) to commit suicide is uncommon and almost exclusively a prerogative of the prison population. Numerous cases of sudden deaths caused by intentional propane and/or butane inhalation have been described, but these cases survived and a description o
• PMID 26005350

Japanese Journal

• Study on Pharmacological Effect of bile Salts, Sodium Scymnol Sulfate, from Rhizoprionodon acutus. I. Effect of Scymnol, Chimaerol and Sodium Scymnol Sulfate on Cerebral Anoxia

• Chemical & pharmaceutical bulletin 42(12), 2532-2535, 1994-12-15
• NAID 110003630882

• Study on Pharmacological Effect of Bile Salts, Sodium Scymnol Sulfate, from Rhizoprionodon acutus. I. Effect of Scymnol, Chimaerol and Sodium Scymnol Sulfate on Cerebral Anoxia.

• Chemical and Pharmaceutical Bulletin 42(12), 2532-2535, 1994
• NAID 130003773025

• Protective Effect of R(-)-1-(Benzo(b)thiophen-5-yl)-2-(2-(N,N-diethylamino)ethoxy)ethanol Hydrochloride (T-588), a Novel Cerebral Activator, aganinst Experimental Cerebral Anoxia.

• The Japanese Journal of Pharmacology 62(1), 81-86, 1993
• NAID 130000840300

Related Links

• Histotoxic hypoxia | definition of histotoxic hypoxia by Medical ...

hypoxia [hi-pok´se-ah] diminished availability of oxygen to the body tissues; its causes are many and varied and includes a deficiency of oxygen in the atmosphere, as in altitude sickness; pulmonary disorders that interfere with ...

• Forms of hypoxia

As you know by this point, hypoxia refers to low oxygen. However, we really haven't described where the oxygen is low with this term. Strictly speaking, the term hypoxia refers to inadequate oxygen available for use by the tissues. ...

Related Pictures

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★リンクテーブル★

リンク元	「組織中毒性低酸素症」
関連記事	「hypoxia」

「組織中毒性低酸素症」

　　[★]

英

histotoxic hypoxia

同

組織中毒性酸素不足症、代謝性低酸素症

「hypoxia」

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• n.

• 低酸素, 低酸素症

関

hypoxia-inducible factor