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Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

Etori Keishi,Saito Yuki C.,Tsujino Natsuko,Sakurai Takeshi
Frontiers in Neuroscience 2014(8), 8, 2014-01
… Fos-immunostaining showed that both compounds affected the activities of arousal-related neurons with different patterns. … The number of Fos-IR noradrenergic neurons in the locus coeruleus was lower in the suvorexant group as compared with the control and C1m-treated groups. …
NAID 120005452005

Dried bonito broth improves cognitive function via the histaminergic system in mice

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Biomedical Research 35(5), 311-319, 2014
… Histamine neurons are projected to almost all areas of the cerebral cortex, and histamine has various behavioral and neurobiological functions, particularly in recognition memory. … Interestingly, the administration of αFMH, which is an inhibitor of histamine biosynthesis, eliminated the increase in the spontaneous alternation behavior ratio by DBB ingestion in the scopolamine-induced amnesia model, suggesting that DBB may improve working memory impairment via activation of the histaminergic neuron system. …
NAID 130004701681

Changes in the electroencephalogram caused by intravenous administration of modafinil under sevoflurane anesthesia in rats

Kano Seiji,Matsuda Yoshiko,Kotani Junihciro
Journal of Osaka Dental University 46(1), 1-4, 2012-04
… Modafinil, a drug for the treatment of hypersomnia and narcolepsy, activates dopaminergic neurons and histaminergic neurons and inhibits the release of gamma-aminobutyric acid to enhance awakening from natural sleep. …
NAID 110009436530