WordNet

(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
someone involved in a contest or battle (as in an agon)
amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/04 02:40:25」(JST)

A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.

H₂ : Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine.

H₃ : Betahistine is a weak Histamine₁ agonist and a very strong Histamine₃ antagonist (paradoxically histamine increasing).

Histamine agonist at the US National Library of Medicine Medical Subject Headings (MeSH)
MeSH list of agents 82017442

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Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism.

Smagin GN1, Song D1, Budac DP2, Waller JA3, Li Y3, Pehrson AL3, Sánchez C4.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Jul 4;68:25-30. doi: 10.1016/j.pnpbp.2016.03.001. Epub 2016 Mar 2.
Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HT transporter inhibitor in vitro. In preclinical and clinical studies vortioxetine demonstrates positive effects
PMID 26945513

Clinical trials with H3-receptor inverse agonists: What they tell us about the role of histamine in the human brain.

Schwartz JC1, Lecomte JM2.
Neuropharmacology.Neuropharmacology.2016 Jul;106:35-6. doi: 10.1016/j.neuropharm.2016.04.006. Epub 2016 Apr 7.
PMID 27060410

Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.

Parmentier R1, Zhao Y2, Perier M1, Akaoka H1, Lintunen M3, Hou Y4, Panula P3, Watanabe T5, Franco P1, Lin JS6.
Neuropharmacology.Neuropharmacology.2016 Jul;106:20-34. doi: 10.1016/j.neuropharm.2015.12.014. Epub 2015 Dec 23.
Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges. Since the central actions of HA are mediated by several receptor subtyp
PMID 26723880