関: hydradenitis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/10 12:25:38」(JST)

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Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate around the eccrine glands.^[1]^:780 This group includes neutrophilic eccrine hidradenitis and recurrent palmoplantar hidradenitis.^[1]^:780

It can also be defined more generally as an inflammation of sweat glands.^[2]

Hidradenitis suppurativa is a chronic cutaneous condition originally thought to be primarily characterized by suppurative inflammation of the apocrine sweat glands.^[3]^:710 However, recent evidence supports that the primary event is follicular hyperkeratosis and obstruction.^[4]

Treatment of symptoms

The Mayo Clinic suggests the following: antibiotics (has generally the least side-effects compared to other treatments); corticosteroids (i.e. prednisone); but corticosteroids have many side effects, including "moon face" for the duration of the medication's trial usage, as well as unwanted hair growth for females and/or osteoporosis with long term use. Tumor necrosis factor (TNF)-alpha inhibitors like infliximab (Remicade) and adalimumab (Humira) have shown promise for some, but it should probably be considered a third-line treatment; as it can increase risk of infection, heart failure and certain types of cancers. Surgery is also available for those overwhelmed by the condition, but it will not cure the condition, just relieve the skin-related issues for a while. The disease is pernicious and is almost always guaranteed to return, if not in the same spot where the surgery was held.^[5]

Some products for adult acne may help relieve some symptoms for Hidradenitis sufferers, although there's no guarantee it will work in all or even most individuals. Birth Control Medication may relieve some symptoms for women; there is a hormonal treatment for men as well but that has not proven to be safe or effective as of yet.^[6]

Alternative treatments include Alpha hydroxy acids (naturally available in small amounts in citrus fruits), Azelaic acid, and zinc. It is not thought that they are as effective as standard medical treatment but they tend to have less side effects. Some suggest tea tree oil and a specific strain of brewer's yeast, called CBS 5926. However, the former can cause contact dermatitis for some as well as breast development in teenage boys and should not be used if one suffers from rosacea as well due to it making the symptoms of that strand of acne worse; the latter (CBS 5962) can cause migraines and intestinal issues for some. None of these have been formally tested by the FDA so beware the risk you take when you forgo traditional Western medicine for herbal supplements.^[7]

References

^ ^a ^b James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
^ "hidradenitis" at Dorland's Medical Dictionary
^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ Sellheyer K, Krahl D (July 2005). ""Hidradenitis suppurativa" is acne inversa! An appeal to (finally) abandon a misnomer". Int. J. Dermatol. 44 (7): 535–40. doi:10.1111/j.1365-4632.2004.02536.x. PMID 15985019.
^ Mayo Clinic: Hidradenitis suppurativa support
^ Birth Control Pills for Certain Female Skin-Related Issues
^ Are there any effective natural skin treatment options?

UpToDate Contents

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1. 汗腺膿瘍（にきび）の治療 treatment of hidradenitis suppurativa acne inversa
2. 汗腺膿瘍（にきび）の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of hidradenitis suppurativa acne inversa
3. 膿疱性皮膚病変を有する患者へのアプローチ approach to the patient with pustular skin lesions
4. 皮膚膿瘍、癤（せつ、フルンケル）、および癰（よう） skin abscesses furuncles and carbuncles
5. 肛門周囲膿瘍：臨床症状、診断、および治療 perianal abscess clinical manifestations diagnosis treatment

English Journal

Treatment of hidradenitis suppurativa with biologic medications.

Lee RA1, Eisen DB2.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2015 Nov;73(5 Suppl 1):S82-8. doi: 10.1016/j.jaad.2015.07.053.
Given the absence of significant improvement in the treatment of hidradenitis suppurativa (HS) with traditional medical and surgical therapies, biologics have piqued the interest of research investigators. The efficacy of biologics in the treatment of inflammatory conditions like psoriasis and rheum
PMID 26470624

Pathophysiology of hidradenitis suppurativa: An update.

Prens E1, Deckers I2.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2015 Nov;73(5 Suppl 1):S8-S11. doi: 10.1016/j.jaad.2015.07.045.
The pathogenesis of hidradenitis suppurativa (HS) or acne inversa is not completely understood. Recent research has led to greater insight into the mechanisms involved in the disease. The primary defect in HS pathophysiology rests with the hair follicle. Follicular occlusion, followed by follicular
PMID 26470623

Laser and light-based treatment options for hidradenitis suppurativa.

Hamzavi IH1, Griffith JL2, Riyaz F2, Hessam S3, Bechara FG3.
Journal of the American Academy of Dermatology.J Am Acad Dermatol.2015 Nov;73(5 Suppl 1):S78-81. doi: 10.1016/j.jaad.2015.07.050.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease that commonly develops painful, deep dermal abscesses and chronic, draining sinus tracts. Classically, pharmacologic and surgical therapies have been effective for reducing lesion activity and inflammation, but provide only modest succe
PMID 26470622