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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/01 16:29:39」(JST)

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Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties.^[1]

It is available for use topically on small skin infections, or as an ingredient in throat lozenges. Johnson & Johnson markets hexylresorcinol in its Neutrogena and RoC skincare products as an anti-aging cream.

A study published in Chemical Research in Toxicology ^[2] shows that 4-hexylresorcinol used as a food additive (E-586) exhibits some estrogenic activity, i.e. resembles action of the female sex hormone estrogen.

In one study, 4-hexylresorcinol increased the shelf life of shrimp by reducing melanosis (black spots).^[3]

In mice with cancer, 4-hexylresorcinol inhibited NF-κB and extended their survival rate.^[4]

References

^ O. Gisvold (1966). C. O. Wilson, O. Gisvold and R. F. Doerge, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry (5th ed.). Philadelphia: Lippincott. pp. 237–262.
^ Amadasi, A; Mozzarelli, A; Meda, C; Maggi, A; Cozzini, P (2009). "Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach". Chem. Res. Toxicol. 22 (1): 52–63. doi:10.1021/tx800048m. PMC 2758355. PMID 19063592.
^ Montero, P. (2006). "Effectiveness of Onboard Application of 4-Hexylresorcinol in Inhibiting Melanosis in Shrimp (Parapenaeus longirostris)". Journal of Food Science. doi:10.1111/j.1365-2621.2004.tb09913.x.
^ Kim, Seong-Gon (2011). "4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells". Oncology Reports.

UpToDate Contents

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1. 小児および思春期における咽頭痛：対症療法 sore throat in children and adolescents symptomatic treatment

English Journal

Development and validation of an analytical method for the determination of 4-hexylresorcinol in food.

Kim YH1, Kim JM1, Lee JS1, Gang SR2, Lim HS3, Kim M3, Lee OH4.
Food chemistry.Food Chem.2016 Jan 1;190:1086-92. doi: 10.1016/j.foodchem.2015.06.051. Epub 2015 Jun 19.
This study presents a method validation for extraction and quantitative analysis of 4-hexylresorcinol residues in shrimp and crab meat using HPLC-FLD. We were focused on the collaboratively analysis of each shrimp and crab meat samples, and developed LC-MS/MS method for the correct confirmation of t
PMID 26213080

Effects of 4-hexylresorcinol on the phenoloxidase from Hyphantria cunea (Lepidoptera: Arctiidae): In vivo and in vitro studies.

Sharifi M1, Ghadamyari M1, Sajedi RH2, Mahmoodi NO3.
Insect science.Insect Sci.2015 Oct;22(5):639-50. doi: 10.1111/1744-7917.12154. Epub 2014 Sep 29.
Insecticidal effects of 4-hexylresorcinol, a phenoloxidase (PO) inhibitor, were determined on Hyphantria cunea (Drury) under laboratory conditions. The LC50 for the 15-d-old larvae was estimated to be 2.95 g/L after 96 h exposure. The activities of glutathione S-transferase (GST) and PO showed a dec
PMID 24995395

Virucidal action of sore throat lozenges against respiratory viruses parainfluenza type 3 and cytomegalovirus.

Shephard A1, Zybeshari S2.
Antiviral research.Antiviral Res.2015 Sep 25;123:158-162. doi: 10.1016/j.antiviral.2015.09.012. [Epub ahead of print]
Most respiratory tract infections are self-limiting and caused by viruses, and do not warrant antibiotic treatment. Despite this, patients with respiratory tract infections often receive antibiotics, fuelling the rise of antibiotic resistance. Therefore, there is a need to encourage patients to try
PMID 26408353

Japanese Journal

甲殻類に残留する4-ヘキシルレゾルシノールのLC/MSによる分析

東京都健康安全研究センター研究年報 (64), 73-78, 2013
NAID 40020193372

エビおよびカニに残留する4-ヘキシルレゾルシノールの分析

食品衛生学雑誌 46(6), 282-285, 2005-12-25
NAID 10031169346

寄生蠕虫症の化学療法に関する研究-21-広東住血線虫,犬糸状虫および犬鉤虫に対するhexylresorcinolの麻痺作用について〔英文〕

寄生虫学雑誌 34(2), p79-86, 1985-04
NAID 40000636650

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リンク元	「ヘキシルレゾルシン」「ヘキシルレゾルシノール」
関連記事	「hexylresorcin」

「ヘキシルレゾルシン」

Hexylresorcinol
Systematic (IUPAC) name
	4-hexylbenzene-1,3-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	136-77-6
ATC code	R02AA12
PubChem	CID: 3610
ChemSpider	21106121
UNII	R9QTB5E82N
KEGG	D04441
ChEMBL	CHEMBL443605
Chemical data
Formula	C12H18O2
Molecular mass	194.27
	SMILES Oc1cc(O)ccc1CCCCCC ;
	InChI InChI=1S/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H3 ; Key:WFJIVOKAWHGMBH-UHFFFAOYSA-N ;
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