English Journal

Sequence-specific nuclease-mediated release of cells tethered by oligonucleotide phospholipids.

Hoffecker IT1, Takemoto N1, Arima Y1, Iwata H2.
Biomaterials.Biomaterials.2015 Jun;53:318-29. doi: 10.1016/j.biomaterials.2015.02.059. Epub 2015 Mar 17.
Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artif
PMID 25890730

Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland.

Mroue R1, Inman J2, Mott J2, Budunova I3, Bissell MJ4.
Developmental biology.Dev Biol.2015 Mar 1;399(1):15-26. doi: 10.1016/j.ydbio.2014.11.026. Epub 2014 Dec 11.
Intercellular communication is essential for glandular functions and tissue homeostasis. Gap junctions couple cells homotypically and heterotypically and co-ordinate reciprocal responses between the different cell types. Connexins (Cxs) are the main mammalian gap junction proteins, and the distribut
PMID 25500615

A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.

Chen Y1, Decker KF, Zheng D, Matkovich SJ, Jia L, Dorn GW 2nd.
The Journal of biological chemistry.J Biol Chem.2013 May 31;288(22):15455-65. doi: 10.1074/jbc.M113.452342. Epub 2013 Apr 19.
Several Bcl2 family proteins are expressed both as mitochondrial-targeted full-length and as cytosolic truncated alternately spliced isoforms. Recombinantly expressed shorter Bcl2 family isoforms can heterotypically bind to and prevent mitochondrial localization of their full-length analogs, thus su
PMID 23603904

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