肝臓毒
WordNet
- any toxin that affects the liver
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/26 10:31:59」(JST)
[Wiki en表示]
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.
It can be a side-effect of medication, or found naturally, as microcystins, or in laboratory environments.
The effects of hepatotoxins depend on the amount, point of entry and distribution speed of the toxin, and on the health of the person.
Hepatotoxic substances
- α-amanitin, a deadly cellular toxin found in Amanita phalloides mushroom (death cap)
- Aflatoxin
- Carbon tetrachloride
- Pyrrolizidine alkaloids, found in many plants in the Boraginaceae, Compositae, and Leguminosae families.
- Luteoskyrin
- allyl alcohol, amiodarone, Aroclor 1254, arsenic, carbamazepine, carbon tetrachloride, diethylnitrosamine, dimethylformamide, diquat, etoposide, indomethacin, methapyrilene, methotrexate, monocrotaline, and 3-methylcholanthrene.[1]
See also
- Mycotoxins
- Hepatotoxicity
- Nephrotoxicity
- Neurotoxicity
- Ototoxicity
References
- ^ Waring, JF; Jolly, RA; Ciurlionis, R; Lum, PY; Praestgaard, JT; Morfitt, DC; Buratto, B; Roberts, C; et al. (2001). "Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles". Toxicology and applied pharmacology 175 (1): 28–42. doi:10.1006/taap.2001.9243. PMID 11509024.
UpToDate Contents
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English Journal
- Okadaic acid is taken-up into the cells mediated by human hepatocytes transporter OATP1B3.
- Ikema S1, Takumi S2, Maeda Y1, Kurimoto T1, Bohda S1, Chigwechokha PK1, Sugiyama Y1, Shiozaki K1, Furukawa T3, Komatsu M4.
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2015 Sep;83:229-36. doi: 10.1016/j.fct.2015.06.006. Epub 2015 Jun 29.
- Okadaic acid is known as a diarrheal shellfish poison. It is thought that there is no specific target organ for okadaic acid after it has been absorbed into the body. However, the details of its pharmacokinetics are still unknown. In this study, we demonstrated that okadaic acid was more toxic to th
- PMID 26134461
- Different responses of primary normal human hepatocytes and human hepatoma cells toward cyanobacterial hepatotoxin microcystin-LR.
- Ikehara T1, Nakashima J2, Nakashima S3, Yasumoto T4.
- Toxicon : official journal of the International Society on Toxinology.Toxicon.2015 Sep 1;105:4-9. doi: 10.1016/j.toxicon.2015.08.025. [Epub ahead of print]
- Microcystins (MCs) are potent hepatotoxins produced by cyanobacteria in aquatic environments. MC-LR, a representative MC, strongly inhibits protein phosphatases 1 and 2A, leading to cell collapse in animal hepatocytes due to hyperphosphorylation of the cytoskeleton and apoptosis due to stimulation o
- PMID 26341421
- Pivotal preclinical trial of the spheroid reservoir bioartificial liver.
- Glorioso JM1, Mao SA1, Rodysill B1, Mounajjed T2, Kremers WK3, Elgilani F4, Hickey RD5, Haugaa H6, Rose CF7, Amiot B8, Nyberg SL9.
- Journal of hepatology.J Hepatol.2015 Aug;63(2):388-98. doi: 10.1016/j.jhep.2015.03.021. Epub 2015 Mar 25.
- BACKGROUND & AIMS: The neuroprotective effect of the spheroid reservoir bioartificial liver (SRBAL) was evaluated in a porcine model of drug-overdose acute liver failure (ALF).METHODS: Healthy pigs were randomized into three groups (standard therapy (ST) alone, ST+No-cell device, ST+SRBAL device
- PMID 25817557
Japanese Journal
- 日本の湖と水田から単離したバクテリアの最適生育条件と細菌によるミクロシスチンの利用
- Hepatic effects among workers exposed to ethylene glycol monoethyl ether acetate
- Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver
Related Links
- hepatotoxinとは。意味や和訳。[名詞] 肝臓毒(素):肝細胞に有毒な物質;特異抗体を作る薬剤に用いる.[語源]1904 - 80万項目以上収録、例文・コロケーションが豊富な無料英和和英辞典。
- Looking for online definition of hepatotoxin in the Medical Dictionary? hepatotoxin explanation free. What is hepatotoxin? Meaning of hepatotoxin medical term. What does hepatotoxin mean? Hepatotoxin | definition of hepatotoxin ...
Related Pictures
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- 英
- hepatotoxin
- 同
- 肝毒素、肝臓毒素
- 関
- アオコ
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肝毒素 : 86 件
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;英:hepatotoxin