胸やけ　　

WordNet

a painful burning sensation in the chest caused by gastroesophageal reflux (backflow from the stomach irritating the esophagus); symptomatic of an ulcer or a diaphragmatic hernia or other disorder (同)pyrosis
intense resentment; "his promotion caused much heartburning among his rivals"

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胸やけ / 不満;ねたみ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/16 20:42:16」(JST)

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This article is about the medical condition. For the film, see Heartburn (film).

Heartburn, also known as pyrosis,^[1] cardialgia, or acid indigestion^[2] is a burning sensation^[3] in the chest, just behind the breastbone or in the epigastrium, the upper central abdomen.^[4] The pain often rises in the chest and may radiate to the neck, throat, or angle of the jaw.

Heartburn is usually associated with regurgitation of gastric acid (gastric reflux) which is the major symptom of gastroesophageal reflux disease (GERD).^[5] It may also be a symptom of ischemic heart disease, though this is true for only 0.6% of those experiencing heartburn.^[6]

Definition

The terms dyspepsia and indigestion are often used interchangeably with heartburn^{[citation needed]}, though some sources emphasize a distinction.^[7] Dyspepsia is defined as a combination of epigastric pain and heartburn.^[8] Heartburn is commonly used interchangeably with gastroesophageal reflux disease rather than just to describe a symptom of burning in one's chest.^[9]

Differential diagnosis

Cardiac and esophageal causes may share similar symptoms as these two structures have the same nerve supply.^[6]

Cardiac disease is one of the first conditions that must be excluded in patients with unexplained chest pain given that patients with chest pain related to GERD cannot be distinguished from those with chest pain due to cardiac conditions. As many as 30% of chest pain patients undergoing cardiac catheterization have findings which do not account for their chest discomfort, and are often defined as having "atypical chest pain" or chest pain of undetermined origin.^[10] According to data recorded in several studies based on ambulatory pH and pressure monitoring, it is estimated that 25% to 50% of these patients have evidence of abnormal GERD.

GERD

Gastroesophageal reflux disease is the most common cause of heartburn. In this condition acid reflux has led to inflammation of the esophagus.^[4]

Functional heartburn

Functional heartburn is heartburn of unknown cause.^[11] It is associated with other functional gastrointestinal disorder like irritable bowel syndrome and is the primary cause of lack of improvement post treatment with proton pump inhibitors (PPIs).^[11] PPIs are however still the primary treatment with response rates in about 50% of people.^[11] The diagnosis is based upon the Rome III criteria of 1) burning retrosternal discomfort 2) absence of GERD as the cause 3) no esophageal motility disorders.^[11] It was found to be present in 22.3% of Canadians in one survey.^[11]

Cardiac

Heartburn is recognized as a symptom of an acute myocardial infarction and angina.^[12] A description of burning or indigestion-like pain increases the risk of acute coronary syndrome, but not to a statistically significant level.^[13] In a group of people presenting to a hospital with GERD symptoms, 0.6% may be due to ischemic heart disease.^[6]

Diagnostic approach

Heartburn can be caused by several conditions and a preliminary diagnosis of GERD is based on additional signs and symptoms. The chest pain caused by GERD has a distinct 'burning' sensation, occurs after eating or at night, and worsens when a person lies down or bends over.^[14] It also is common in pregnant women, and may be triggered by consuming food in large quantities, or specific foods containing certain spices, high fat content, or high acid content.^[14]^[15] If the chest pain is suspected to be heartburn, patients may undergo an upper GI series to confirm the presence of acid reflux.^[15]^[16] Heartburn or chest pain after eating or drinking and combined with difficulty swallowing may indicate esophageal spasms.^[17]

GI cocktail

Relief of symptoms 5 to 10 minutes after the administration of viscous lidocaine and an antacid increases the suspicion that the pain is esophageal in origin.^[18] This however does not rule out a potential cardiac cause^[19] as 10% of cases of discomfort due to cardiac causes are improved with antacids.^[20]

Biochemical

Esophageal pH monitoring : A probe can be placed via the nose into the esophagus to record the level of acidity in the lower esophagus. Because some degree of variation in acidity is normal, and small reflux events are relatively common, esophageal pH monitoring can be used to document reflux in real-time.

Mechanical

Manometry: In this test, a pressure sensor (manometer) is passed through the mouth into the esophagus and measures the pressure of the lower esophageal sphincter directly.

Endoscopy: The esophageal mucosa can be visualized directly by passing a thin, lighted tube with a tiny camera known as an endoscope attached through the mouth to examine the esophagus and stomach. In this way, evidence of esophageal inflammation can be detected, and biopsies taken if necessary. Since an endoscopy allows a doctor to visually inspect the upper digestive tract the procedure may help identify any additional damage to the tract that may not have been detected otherwise.

Biopsy: A small sample of tissue from the esophagus is removed. It is then studied to check for inflammation, cancer, or other problems.

Treatment

The treatment of heartburn depends on the underlying cause. Medicines such as H2 receptor antagonists or proton pump inhibitors are effective for gastritis and GERD, the two most common causes of heartburn. Antibiotics are used if H. pylori is present.

Epidemiology

About 42% of the United States population has had heartburn at some point.^[21]

References

^ "Pyrosis definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms". http://www.medterms.com/script/main/art.asp?articlekey=32175.
^ "Heartburn, Gastroesophageal Reflux (GER), and Gastroesophageal Reflux Disease (GERD)". http://digestive.niddk.nih.gov/ddiseases/pubs/gerd/.
^ "heartburn" at Dorland's Medical Dictionary
^ ^a ^b Differential diagnosis in primary care. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2008. pp. 211. ISBN 0-7817-6812-8.
^ Heartburn
^ ^a ^b ^c Kato H, Ishii T, Akimoto T, Urita Y, Sugimoto M (April 2009). "Prevalence of linked angina and gastroesophageal reflux disease in general practice". World J. Gastroenterol. 15 (14): 1764–8. doi:10.3748/wjg.15.1764. PMC 2668783. PMID 19360921. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2668783/.
^ Stephen C. Hauser; John J. Poterucha (26 August 2008). Mayo Clinic Gastroenterology and Hepatology Board Review. Third Edition. Informa Health Care. pp. 8–. ISBN 978-1-4200-9223-3. http://books.google.com/?id=vgvDc2Rf3BQC&pg=PA8. Retrieved 19 May 2010.
^ Delaney B, Ford AC, Forman D, Moayyedi P, Qume M (2005). Delaney, Brendan. ed. "Initial management strategies for dyspepsia". Cochrane Database Syst Rev (4): CD001961. doi:10.1002/14651858.CD001961.pub2. PMID 16235292.
^ Sajatovic, Martha; Loue, Sana; Koroukian, Siran M. (2008). Encyclopedia of aging and public health. Berlin: Springer. pp. 419. ISBN 0-387-33753-9.
^ "Heartburn and Regurgitation". http://www.uwgi.org/guidelines/ch_03/ch03txt.htm. Retrieved 2010-06-21.
^ ^a ^b ^c ^d ^e Fass R (January 2009). "Functional heartburn: what it is and how to treat it". Gastrointest. Endosc. Clin. N. Am. 19 (1): 23–33, v. doi:10.1016/j.giec.2008.12.002. PMID 19232278.
^ Waller CG (December 2006). "Understanding prehospital delay behavior in acute myocardial infarction in women". Crit Pathw Cardiol 5 (4): 228–34. doi:10.1097/01.hpc.0000249621.40659.cf. PMID 18340239.
^ Woo KM, Schneider JI (November 2009). "High-risk chief complaints I: chest pain--the big three". Emerg. Med. Clin. North Am. 27 (4): 685–712, x. doi:10.1016/j.emc.2009.07.007. PMID 19932401.
^ ^a ^b The Mayo Clinic Heartburn page. Accessed May 18, 2010
^ ^a ^b The MedlinePlus Heartburn page. Accessed May 18, 2010
^ National Digestive Diseases Information Clearinghouse (NDDIC): Upper GI Series. Accessed May 18, 2010
^ MedlinePlus: Esophageal spasms. Accessed April 18, 2010
^ Differential diagnosis in primary care. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2008. pp. 213. ISBN 0-7817-6812-8.
^ Swap CJ, Nagurney JT (November 2005). "Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes". JAMA 294 (20): 2623–9. doi:10.1001/jama.294.20.2623. PMID 16304077.
^ Hanke, Barbara K.; Schwartz, George Robert (1999). Principles and practice of emergency medicine. Baltimore: Williams & Wilkins. pp. 656. ISBN 0-683-07646-9.
^ Kushner PR (April 2010). "Role of the primary care provider in the diagnosis and management of heartburn". Curr Med Res Opin 26 (4): 759–65. doi:10.1185/03007990903553812. PMID 20095795.

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UpToDate Contents

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1. 成人における胃食道逆流症の臨床症状および診断 clinical manifestations and diagnosis of gastroesophageal reflux in adults
2. 成人における胃食道逆流症の内科的マネージメント medical management of gastroesophageal reflux disease in adults
3. 小児および思春期における胃食道逆流症のマネージメント management of gastroesophageal reflux disease in children and adolescents
4. 成人における難治性胃食道逆流症へのアプローチ approach to refractory gastroesophageal reflux disease in adults
5. 小児および思春期における胃食道逆流症の臨床症状および診断 clinical manifestations and diagnosis of gastroesophageal reflux disease in children and adolescents

English Journal

Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial.

Fallah R1, Sabbaghzadegan S2, Karbasi SA3, Binesh F4.
Nutrition (Burbank, Los Angeles County, Calif.).Nutrition.2015 Nov-Dec;31(11-12):1358-61. doi: 10.1016/j.nut.2015.05.024. Epub 2015 Jul 6.
OBJECTIVE: Serum zinc level might be related to pathogenesis of febrile seizure (FS). The purpose of this study was to evaluate efficacy and safety of oral zinc supplementation on FS recurrence prevention in non-zinc-deficient children.MATERIALS AND METHODS: In a randomized clinical study, one hundr
PMID 26429655

Randomised clinical trial: the clinical efficacy and safety of an alginate-antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China.

Sun J1, Yang C2, Zhao H3, Zheng P4, Wilkinson J5, Ng B5, Yuan Y1.
Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2015 Oct;42(7):845-54. doi: 10.1111/apt.13334. Epub 2015 Jul 31.
BACKGROUND: There is a paucity of large-scale studies evaluating the clinical benefit of the Gaviscon Double Action (DA) alginate-antacid formulation for treating gastroesophageal reflux disease (GERD) symptoms.AIM: Randomised double-blind placebo-controlled parallel-group study to evaluate efficacy
PMID 26228097

Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior.

Levy MD1, Bhattacharya B2.
American journal of clinical pathology.Am J Clin Pathol.2015 Oct;144(4):592-600. doi: 10.1309/AJCPGK8QTYPUQJYL.
OBJECTIVES: Fundic gland polyps (FGPs) occur in two clinical settings, sporadic and syndromic. Epithelial dysplasia is rare in sporadic FGPs, and progression data from large series are lacking. The aim of this study was to evaluate the clinical, morphologic, and immunohistochemical features in a lar
PMID 26386080

Expression of Proteinase-activated Receptor-2 in the Esophageal Mucosa of Gastroesophageal Reflux Disease Patients: A Histomorphologic and Immunohistochemical Study.

Abd El-Rehim DM1, Fath El-Bab HK, Kamal EM.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry.Appl Immunohistochem Mol Morphol.2015 Oct;23(9):646-52. doi: 10.1097/PAI.0000000000000130.
Data are limited regarding the role of proteinase-activated receptor-2 (PAR-2) in the esophageal mucosa in gastroesophageal reflux disease (GERD) patients. Our aim was to study PAR-2 expression and its relationship with different GERD-related clinical and pathologic parameters. Histomorphologic alte
PMID 25265427

Japanese Journal

Rikkunshito improves symptoms in PPI-refractory GERD patients : a prospective, randomized, multicenter trial in Japan

TOMINAGA Kazunari,IWAKIRI Ryuichi,FUJIMOTO Kazuma,FUJIWARA Yasuhiro,TANAKA Mio,SHIMOYAMA Yasuyuki,UMEGAKI Eiji,HIGUCHI Kazuhide,KUSANO Motoyasu,ARAKAWA Tetsuo
Journal of gastroenterology 47(3), 284-292, 2012-03-01
NAID 10030560078

Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients

SAVARINO Edoardo,ZENTILIN Patrizia,TUTUIAN Radu,POHL Daniel,GEMIGNANI Lorenzo,MALESCI Alberto,SAVARINO Vincenzo
Journal of gastroenterology 47(2), 159-168, 2012-02-01
NAID 10030296148

Comparisons of symptoms reported by elderly and non-elderly patients with GERD

FURUTA Kenji,KUSHIYAMA Yoshinori,KAWASHIMA Kousaku,SHIBAGAKI Kotaro,KOMAZAWA Yoshinori,FUJISHIRO Hirofumi,KITAJIMA Naoto,ADACHI Kyoichi,KINOSHITA Yoshikazu
Journal of gastroenterology 47(2), 144-149, 2012-02-01
NAID 10030296077

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高木恒太朗
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