WordNet
- relating to or characterized by granulomas
- inflammation of the thyroid gland
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/28 23:24:42」(JST)
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De Quervain's thyroiditis |
Micrograph showing a granuloma in subacute thyroiditis. H&E stain.
|
Classification and external resources |
ICD-10 |
E06.1 |
ICD-9-CM |
245.1 |
DiseasesDB |
3474 |
MedlinePlus |
000375 |
eMedicine |
med/534 |
MeSH |
D013968 |
de Quervain's thyroiditis, can also be known as subacute granulomatous thyroiditis or Giant Cell Thyroiditis. Males and females of all ages are affected. It is a member of the group of thyroiditis conditions known as resolving thyroiditis.
Contents
- 1 Terminology
- 2 Causes
- 3 Presentation
- 4 Treatment
- 5 Eponym
- 6 References
Terminology
It is sometimes called subacute thyroiditis,[1] but there are other forms of subacute thyroiditis, subacute lymphocytic thyroiditis, post partum thyroiditis, and autoimmune thyroiditis all of which, in contrast to DeQuervain's, are typically painless or "silent".
It is also sometimes called "painful subacute thyroiditis".[2] This is in contrast to subacute lymphocytic thyroiditis, which is also sometimes called "painless thyroiditis".
Causes
Some cases may be viral in origin, perhaps preceded by an upper respiratory tract infection.[citation needed] Viral causes include Coxsackie virus, mumps and adenoviruses.[citation needed] Some cases develop postpartum[citation needed].
Presentation
Patients will experience a hyperthyroid period as the cellular lining of colloid spaces fails, allowing abundant colloid into the circulation, with neck pain and fever. Patients typically then become hypothyroid as the pituitary reduces TSH production and the inappropriately released colloid is depleted before resolving to euthyroid. The symptoms are those of hyperthyroidism and hypothyroidism. In addition, patients may suffer from painful dysphagia. There are multi-nucleated giant cells on histology. Thyroid antibodies can be present in some cases. The clinical presentation during the hyperthyroid phase can mimic those of Diffuse Toxic Goiter or Graves' disease. In such cases, a radionuclide thyroid uptake and scan can be helpful, since subacute thyroiditis will result in decreased isotope uptake, while Graves' disease will generally result in increased uptake. Distinguishing between these two types of disease is important, since Graves' disease and Diffuse Toxic Goiter can be treated with radioiodine therapy, but subacute thyroiditis is usually self-limited and is not treated with radioiodine. DIAGNOSTIC Most consistent clinical scenario: mixed, cellular infiltration with occasional multinucleate giant cells, increase ESR (erythrocyte sedimentation)
Treatment
Treatment is beta blockers and NSAIDs (or corticosteroids if NSAIDs are ineffective).
Eponym
It is named for Fritz de Quervain.[3] It should not be confused with DeQuervain's syndrome.
References
- ^ Topuzovic N, Smoje J, Karner I (October 1997). "The therapeutic approach in subacute (de Quervain's) thyroiditis". J. Nucl. Med. 38 (10): 1665. PMID 9379217.
- ^ Peter SA (October 1992). "Painful subacute thyroiditis (de Quervain's thyroiditis)". J Natl Med Assoc 84 (10): 877–9. PMC 2571803. PMID 1404465.
- ^ synd/1139 at Who Named It?
UpToDate Contents
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English Journal
- Assessment of Diffuse Thyroid Disease by Strain Ratio in Ultrasound Elastography.
- Yang Z1, Zhang H2, Wang K3, Cui G3, Fu F4.
- Ultrasound in medicine & biology.Ultrasound Med Biol.2015 Aug 22. pii: S0301-5629(15)00458-5. doi: 10.1016/j.ultrasmedbio.2015.07.012. [Epub ahead of print]
- The goal of this study was to explore the value of strain ratio from real-time elastography in the semi-quantitative assessment of diffuse thyroid disease. Fifty-one patients with primary hyperthyroidism, 70 with Hashimoto's thyroiditis, 8 with subacute thyroiditis and 43 with normal healthy thyroid
- PMID 26306430
- The importance of the incidental thyroid gland uptake during Tc-99m MIBI myocardial perfusion scintigraphy.
- Karacavus S1, Ede H, Sarikaya S, Delibas N, Kaya E, Erbay AR.
- European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2015 Aug;19(15):2781-5.
- OBJECTIVE: The purpose of study was to investigate whether incidental thyroid gland uptake had an important during Tc-99m sestamibi (MIBI) myocardial perfusion scintigraphy (SPECT).PATIENTS AND METHODS: In the presented study, 968 consecutive patients were evaluated for the presence or absence of th
- PMID 26241530
- Cytomegalovirus subacute thyroiditis in a patient treated by infliximab for psoriatic arthritis.
- André R1, Opris A1, Costantino F2, Hayem G1, Breban M3.
- Joint, bone, spine : revue du rhumatisme.Joint Bone Spine.2015 Jul 13. pii: S1297-319X(15)00107-4. doi: 10.1016/j.jbspin.2015.06.001. [Epub ahead of print]
- PMID 26184533
Japanese Journal
- 全身性進行性硬化症,シェーグレン症候群,慢性甲状腺炎の治療中に発症したサルコイドーシスの一例
- 青木 由香,森松 嘉孝,溝口 祐輔,上野 二菜,清川 哲志,河野 文夫,相澤 久道
- サルコイドーシス/肉芽腫性疾患 25(1), 61-65, 2005
- 症例は, 51才女性. 11年前から慢性甲状腺炎で治療中, 2002年6月頃より手指腫脹, 口腔内乾燥症状が出現し, 全身性進行性硬化症およびシェーグレン症候群と診断された. 2004年8月の健康診断にて胸部X線像異常を指摘され当科紹介. 胸部X線にて両側肺門リンパ節腫大を認めたため, 精査目的で入院となった. 胸部CTでは, 縦隔・両側肺門リンパ節の腫大, 肺野にはびまん性に粒状影を認めた. 気 …
- NAID 130004246669
- Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake
- Fujii Sumie,Miwa Umeo,Seta Takashi [他],OHOKA Takio,MIZUKAMI Yuji
- Internal medicine 42(8), 704-709, 2003-08-01
- … A 48-year-old woman with transient thyrotoxicosis, having a slightly high thyroidal 99mTc uptake (3.9% at 20 m) or radioactive iodine uptake (RAIU) (17.3% at 4 hour) and subacute thyroiditis (SAT)-like symptoms, signs and histological diagnosis (extensive cellular destruction and granulomatous inflammatory change), showed positive TRAb (59.9%) and TSAb (194%) activity. …
- NAID 50000276283
- Apoptosis of thyrocytes and effector cells during induction and resolution of granulomatous experimental autoimmune thyroiditis
- TANG Haiwen,CHEN Kemin,WEI Yongzhong,SHARP C Gordon,MCKEE Lara,BRALEY-MULLEN Helen
- International immunology 12(12), 1629-1639, 2001-12-01
- NAID 10008031489
Related Links
- Granulomatous thyroiditis, also called subacute thyroiditis, giant-cell thyroiditis, pseudotuberculous thyroiditis, or de Quervain’s thyroiditis, inflammatory disease of the thyroid gland, of unknown but presumably viral origin. It may ...
- Dedicated to the mission of bringing free or low-cost educational materials and information to the global ultrasound community. ... Presentation A 39-year-old man presents with acute onset of pain in the thyroid region, exacerbated ...
Related Pictures
★リンクテーブル★
[★]
- 英
- granulomatous thyroiditis
- 関
- 亜急性甲状腺炎
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- granuloma