gouty tophus

痛風結節

WordNet

1. a painful inflammation of the big toe and foot caused by defects in uric acid metabolism resulting in deposits of the acid and its salts in the blood and joints (同)gouty_arthritis, urarthritis
2. suffering from gout
3. a deposit of urates around a joint or in the external ear; diagnostic of advanced or chronic gout (同)chalkstone

PrepTutorEJDIC

1. 〈U〉痛風 / 〈C〉(特に血の)滴り,塊
2. 痛風の,痛風にかかった

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/13 23:45:04」(JST)

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Tophus (Harrison Syndrome)
A tophus on the elbow of a middle aged man with chronic gout
Classification and external resources
ICD-9-CM	274.0
DiseasesDB	29389

A tophus (Latin: "stone", plural tophi) is a deposit of uric acid crystals, in the form of monosodium urate crystals, in people with longstanding hyperuricemia (high levels of uric acid in the blood). Tophi are pathognomonic for the disease gout. Most people with tophi have had previous attacks of acute arthritis, eventually leading to the formation of tophi. Chronic tophaceous gout is known as Harrison Syndrome.

Tophi form in the joints, cartilage, bones, and other places throughout the body. Sometimes, tophi break through the skin and appear as white or yellowish-white, chalky nodules. Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol, febuxostat) or increase uric acid elimination from the body through the kidneys (e.g., probenecid), this can be referred to as refractory chronic gout (RCG). They are more apt to appear early in the course of the disease in people who are older.

Although less common, tophi can also form in the kidneys and nasal cartilage.

Additional images

• Micrograph of a gouty tophus

• A tophus inside a knee joint being removed by arthroscopic surgery

• Tophus of Uric Acid Crystals from toe joint fluid (100x polarized light)

See also

• Chondrocalcinosis (pseudogout)

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 痛風の臨床症状および診断 clinical manifestations and diagnosis of gout
• 2. 痛風性関節炎の病態生理 pathophysiology of gouty arthritis
• 3. 無症候性高尿酸血症 asymptomatic hyperuricemia
• 4. 痛風再発の予防 prevention of recurrent gout
• 5. 腎移植レシピエントにおける高尿酸血症および痛風 hyperuricemia and gout in renal transplant recipients

English Journal

• Gouty tophus of the second metacarpal simulating a malignancy with pathologic fracture.

• Yaegashi Y, Nishida J, Oyama K.
• The Journal of hand surgery.J Hand Surg Am.2013 Jan;38(1):208-9. doi: 10.1016/j.jhsa.2012.10.044.
• PMID 23261202

• [A man with a yellow coloured abnormality of his finger].

• Tomlow B, Swen N.SourceMedisch Centrum Alkmaar, Afd. Interne Geneeskunde, Alkmaar, the Netherlands. 1000702@mca.nl
• Nederlands tijdschrift voor geneeskunde.Ned Tijdschr Geneeskd.2013;157(3):A5024.
• A 83-year-old man presented to the emergency department with signs of diabetes mellitus de novo and a yellow coloured abnormality of his left index finger. A plain radiograph of the left hand showed destruction of the proximal interphalangeal joint of digit II. With use of polarised light microscopy
• PMID 23328011

Japanese Journal

• 症例 両母趾・右V趾に発症した痛風結節に対し手術的治療を要した1例

• 整形・災害外科 58(7), 965-969, 2015-06
• NAID 40020498878

• 痛風関節炎

• 皮膚の科学 14(5), 205-206, 2015
• NAID 130005119866

• 骨破壊を伴った多発性痛風結節の 1 例

• 西日本皮膚科 77(3), 217-219, 2015
• NAID 130005101058

Related Links

• Tophus - Wikipedia, the free encyclopedia

Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone ...

• Why are tophi important to gout sufferers? » GoutPal

21 Feb 2011 ... What are tophi and are they serious? A single small tophus is easy to miss, but will grow & burst skin. Even worse, they destroy joints. See how to stop them.

Related Pictures

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★リンクテーブル★

リンク元	「痛風結節」
関連記事	「gouty」

「痛風結節」

　　[★]

英

tophus, tophi, gouty tophus

関

痛風

「gouty」

　　[★]

• adj.

• 痛風性の、痛風の

関

gout