WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- hormone secreted by the anterior pituitary gland and placenta; stimulates the gonads and controls reproductive activity (同)gonadotrophin, gonadotropic_hormone, gonadotrophic hormone
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/15 20:59:35」(JST)
[Wiki en表示]
The gonadotropin receptors are a group of receptors that bind a group of pituitary hormones called gonadotropins. They include the:
- Follicle-stimulating hormone receptor (FSHR) - binds follicle-stimulating hormone (FSH)
- Luteinizing hormone receptor (LHR) - binds luteinizing hormone (LH) and human chorionic gonadotropin (hCG)
See also
- GnRH receptor
- Sex hormone receptor
Neuropeptide receptors
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G protein-coupled receptor |
Hormone receptors |
Hypothalamic |
- CRH
- FSH
- LHRH
- TRH
- Somatostatin
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Pituitary |
- Vasopressin
- Oxytocin
- LHCG
- TSH
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Other |
- Atrial natriuretic factor
- Calcitonin
- Cholecystokinin
- VIP
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Opioid receptors |
- Delta
- Kappa
- Mu
- Nociceptin
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Other neuropeptide receptors |
- Angiotensin
- Bradykinin
- Tachykinin
- Calcitonin gene-related peptide
- Galanin
- GPCR neuropeptide
- Neurotensin
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Type I cytokine receptor |
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Enzyme-linked receptor |
- Atrial natriuretic factor
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Other |
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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Gonadotropins and GnRH (G03G)
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Gonadotropin
preparations |
Gonadotropins |
- Follicle-stimulating hormone
- Human chorionic gonadotropin
- Luteinizing hormone
- Menotropin
- Urofollitropin
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Antigonadotropins |
- Sex steroids (via negative feedback on the HPG axis): Androgens (incl. anabolic steroids, e.g., nandrolone, oxandrolone)
- Estrogens
- Progestogens (incl., allylestrenol, chlormadinone acetate, cyproterone acetate, delmadinone acetate, dydrogesterone, medroxyprogesterone acetate, megestrol acetate, nomegestrol acetate, norethisterone acetate, progesterone, spironolactone)
- Steroid synthesis inhibitors: Danazol
- Gestrinone
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GnRH inhibitors |
Agonists |
- Buserelin
- Deslorelin
- GnRH (gonadorelin)
- Goserelin
- Histrelin
- Leuprorelin
- Nafarelin
- Triptorelin
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Antagonists |
- Abarelix
- Cetrorelix
- Degarelix
- Elagolix†
- Ganirelix
- Relugolix§
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of reproductive medicine
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Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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UpToDate Contents
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English Journal
- Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice.
- Xie C1, Jonak CR2, Kauffman AS3, Coss D4.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Aug 15;411:223-31. doi: 10.1016/j.mce.2015.04.033. Epub 2015 May 6.
- cFOS is a pleiotropic transcription factor, which binds to the AP1 site in the promoter of target genes. In the pituitary gonadotropes, cFOS mediates induction of FSHβ and GnRH receptor genes. Herein, we analyzed reproductive function in the cFOS-deficient mice to determine its role in vivo. In the
- PMID 25958044
- Testosterone supplementation in men: a practical guide for the gynecologist and obstetrician.
- Owen RC1, Elkelany OO, Kim ED.
- Current opinion in obstetrics & gynecology.Curr Opin Obstet Gynecol.2015 Aug;27(4):258-64. doi: 10.1097/GCO.0000000000000192.
- PURPOSE OF REVIEW: Prescribing habits for the treatment of symptomatic hypogonadism have recently stirred controversy surrounding testosterone replacement therapy. As a result, the gynecologist will need to recognize this iatrogenic form of decreased sperm production in couples seeking fertility adv
- PMID 26107780
- Emergence of an Ancestral Glycoprotein Hormone in the Pituitary of the Sea Lamprey, a Basal Vertebrate.
- Sower SA1, Decatur WA1, Hausken KN1, Marquis TJ1, Barton SL1, Gargan J1, Freamat M1, Wilmot M1, Hollander L1, Hall JA1, Nozaki M1, Shpilman M1, Levavi-Sivan B1.
- Endocrinology.Endocrinology.2015 Aug;156(8):3026-3037. Epub 2015 Jun 11.
- The gnathostome (jawed vertebrates) classical pituitary glycoprotein hormones, FSH, LH, and TSH, consist of a common α-subunit (GpA1) and unique β-subunits (Gpβ1, -2, and -3), whereas a recently identified pituitary glycoprotein hormone, thyrostimulin, consists of GpA2 and GpB5. This paper report
- PMID 26066074
Japanese Journal
- Design and synthesis of fluorescent probes for GPR54.
- Kaneda Masato,Misu Ryosuke,Ohno Hiroaki,Hirasawa Akira,Ieda Nahoko,Uenoyama Yoshihisa,Tsukamura Hiroko,Maeda Kei-ichiro,Oishi Shinya,Fujii Nobutaka
- Bioorganic & medicinal chemistry 22(13), 3325-3330, 2014-07-01
- … Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54). … In this study, several fluorescent probes have been designed and synthesized for rat GPR54 through the modification of the N-terminus of rat kisspeptins to allow for the visualization of the expression and localization of kisspeptin receptor(s) in living cells and native tissues. …
- NAID 120005466733
- Current Perspective : Desensitization by Different Strategies of Epidermal Growth Factor Receptor and ErbB4
- Yamamoto Hideyuki,Higa-Nakamine Sayomi,Noguchi Nobuhiro [他]
- Journal of pharmacological sciences 124(3), 287-293, 2014-03
- NAID 40020026267
- Potential role of hCG in apoptosis of human luteinized granulosa cells
- HIRATA Rei,HOJO Takuo,SANO Masahiro,HAYASHI Nobuyoshi,OKUDA Kiyoshi
- Journal of Reproduction and Development, 2014
- … In pregnant women, human chorionic gonadotropin (hCG) secreted by the conceptus prevents luteolysis. … To clarify the maintenance mechanism of the human CL, we investigated the effects of hCG and P4 receptor antagonists, onapristone (OP) and RU486, on the viability of hLGCs. …
- NAID 130004703739
Related Links
- WO1993020199A1 1993-10-14 HUMAN GONADOTROPIN RECEPTOR (FSH RECEPTOR) WO1994029447A2 1994-12-22 DNA CODING FOR THE HUMAN THYROTROPIN-RELEASING HORMONE RECEPTOR
- This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope ...
Related Pictures
★リンクテーブル★
[★]
- 英
- gonadotropin receptor
- 関
- ゴナドトロピンレセプター、性腺刺激ホルモン受容体、性腺刺激ホルモンレセプター
[★]
- 英
- gonadotropin receptor
- 関
- ゴナドトロピン受容体、ゴナドトロピンレセプター、性腺刺激ホルモンレセプター
[★]
- 英
- gonadotropin receptor
- 関
- ゴナドトロピン受容体、性腺刺激ホルモン受容体、性腺刺激ホルモンレセプター
[★]
- 英
- gonadotropin receptor
- 関
- ゴナドトロピン受容体、ゴナドトロピンレセプター、性腺刺激ホルモン受容体
[★]
黄体化ホルモン/ヒト絨毛性ゴナドトロピン受容体
[★]
性腺刺激ホルモン