グリコシルホスファチジルイノシトールジアシルグリセロールリアーゼ
- 関
- glycosylphosphatidylinositol-specific phospholipase C、GPI-PLC
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/25 18:27:06」(JST)
[Wiki en表示]
| glycosylphosphatidylinositol diacylglycerol-lyase |
| Identifiers |
| EC number |
4.6.1.14 |
| CAS number |
129070-68-4 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) is an enzyme that catalyzes the chemical reaction
- 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
Hence, this enzyme has one substrate, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and two products, 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]. Other names in common use include (glycosyl)phosphatidylinositol-specific phospholipase C, GPI-PLC, GPI-specific phospholipase C, VSG-lipase, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, variant-surface-glycoprotein phospholipase C, 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol, and diacylglycerol-lyase (1,2-cyclic-phosphate-forming).
References
- Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT (1986). "A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein". J. Biol. Chem. 261 (29): 13813–9. PMID 3759991.
- Carnall N, Webb H, Carrington M (1997). "Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei". Mol. Biochem. Parasitol. 90 (2): 423–32. doi:10.1016/S0166-6851(97)00177-1. PMID 9476790.
- Armah DA, Mensa-Wilmot K (2000). "Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei". J. Biol. Chem. 275 (25): 19334–42. doi:10.1074/jbc.M001798200. PMID 10764777.
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Phosphorus-oxygen lyases (EC 4.6)
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|
| 4.6.1 |
Adenylate cyclase
(4.6.1.1) |
- intracellular: ADCY1
- ADCY2
- ADCY3
- ADCY4
- ADCY5
- ADCY6
- ADCY7
- ADCY8
- ADCY9
- ADCY10
- Extracellular adenylate cyclase
|
|
Guanylate cyclase
(4.6.1.2) |
- soluble guanylyl cyclase: GUCY1A2
- GUCY1A3
- GUCY1B2
- GUCY1B3
- guanylate cyclase-coupled receptor: GUCY2C
- GUCY2D
- ANP (NPR1
- NPR2)
|
|
| Other |
- Cytidylate cyclase
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Phosphatidylinositol diacylglycerol-lyase
- Glycosylphosphatidylinositol diacylglycerol-lyase
- FAD-AMP lyase (cyclizing)
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- [Role of Ca ions in the induction of heat-resistance of wheat coleoptiles by brassinosteroids].
- Kolupaev YE, Vayner AA, Yastreb TO, Oboznyi AI, Khripach VA.
- Ukrainian biochemical journal.Ukr Biochem J.2015 Jan-Feb;87(1):127-33.
- The involvement of Ca2+ into the signal transduction of exogenous brassinosteroids (BS) (24-epi-brassinolide-24-EBL and 24-epicastasterone-24-ECS) causing the increase of heat resistance of the cells of wheat (Triticum aestivum L.) coleoptiles was investigated using calcium chelator EGTA and inhibit
- PMID 26036139
- Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes.
- Sunter J1, Webb H, Carrington M.
- PLoS pathogens.PLoS Pathog.2013;9(8):e1003566. doi: 10.1371/journal.ppat.1003566. Epub 2013 Aug 22.
- PMID 23990786
- The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils.
- Liu G1, Yang Y, Yang S, Banerjee S, De Freitas A, Friggeri A, Davis KI, Abraham E.
- PloS one.PLoS One.2011;6(10):e25843. doi: 10.1371/journal.pone.0025843. Epub 2011 Oct 5.
- PMID 21998707
Related Links
- Definition of glycosylphosphatidylinositol diacylglycerol-lyase in the Definitions.net dictionary. Meaning of glycosylphosphatidylinositol diacylglycerol-lyase. What does glycosylphosphatidylinositol diacylglycerol-lyase mean?
- glycosylphosphatidylinositol diacylglycerol-lyase activity Acc: GO:0047396 Aspect: Molecular Function Desc: Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha ...
★リンクテーブル★
[★]
- 関
- glycosylphosphatidylinositol diacylglycerol-lyase、glycosylphosphatidylinositol-specific phospholipase C
[★]
グリコシルホスファチジルイノシトール特異的ホスホリパーゼC
- 関
- glycosylphosphatidylinositol diacylglycerol-lyase、GPI-PLC
[★]
- 英
- glycosylphosphatidylinositol diacylglycerol-lyase
- 関
- グリコシルホスファチジルイノシトール特異的ホスホリパーゼC
[★]
グリコシルホスファチジルイノシトール
- 関
- glycosyl-phosphatidylinositol、glycosylphosphatidylinositol anchor、GPI
[★]
ジアシルグリセロール。DG DAG