glucuronides

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/20 21:28:20」(JST)

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Morphine-6-glucuronide, a major metabolite of morphine

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. The glucuronides belong to the glycosides.

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.

Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.

Examples

• Miquelianin (Quercetin 3-O-glucuronide)
• Morphine-6-glucuronide
• Scutellarein-7-glucuronide

References

UpToDate Contents

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• 1. ビリルビン代謝 bilirubin metabolism
• 2. 副腎ステロイドの代謝 metabolism of adrenal steroids
• 3. 血清ビリルビン定量の臨床的側面 clinical aspects of serum bilirubin determination
• 4. 副腎アンドロゲンの測定 measurement of adrenal androgens
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English Journal

• Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC-MS, LC-MS (n) , and LC-HR-MS-MS.

• Michely JA1, Helfer AG1, Brandt SD2, Meyer MR1,3, Maurer HH4.
• Analytical and bioanalytical chemistry.Anal Bioanal Chem.2015 Oct;407(25):7831-42. doi: 10.1007/s00216-015-8955-0. Epub 2015 Aug 22.
• N,N-Diallyltryptamine (DALT) and 5-methoxy-DALT (5-MeO-DALT) are synthetic tryptamine derivatives commonly referred to as so-called new psychoactive substances (NPS). They have psychoactive effects that may be similar to those of other tryptamine derivatives. The objectives of this work were to stu
• PMID 26297461

• Cyclosporin A-sensitive cytotoxicity of flurbiprofen non-stereoselectively mediated by cytochrome P450 metabolism in three-dimensional cultured rat hepatocytes.

• Tanino T1, Funakami Y2, Nagai N2, Kato Y3.
• The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2015 Oct;67(10):1406-15. doi: 10.1111/jphp.12443. Epub 2015 Jun 23.
• OBJECTIVES: 2-Arylpropionic acid (profen) drugs are associated with severe hepatotoxicity; however, risk factors are still poorly understood. Acyl-coenzyme A (acyl-CoA) thioesters of profen drugs play a more important role in the covalent binding to rat hepatocyte proteins than the respective acyl-g
• PMID 26099455

Japanese Journal

• Estimating the Differences of UGT1A1 Activity in Recombinant UGT1A1 Enzyme, Human Liver Microsomes and Rat Liver Microsome Incubation Systems <i>in Vitro</i>

• Biological and Pharmaceutical Bulletin 38(12), 1910-1917, 2015
• NAID 130005112633

• 医薬品による毒性発現に係わるオーファン加水分解酵素の機能解明

• YAKUGAKU ZASSHI 135(11), 1235-1244, 2015
• NAID 130005105491

Related Links

• Glucuronides - definition of Glucuronides by Medical dictionary

glucuronide Glucuronides glucuronosyltransferase GLUD1 GLUD2 glue glue ear Glue Sniffing glue-sniffing Gluge Gluge corpuscles Gluge, Gottlieb Glugea GLUL GLUT GLUT1 deficiency syndrome type 1 GLUT1 deficiency ? ...

• glucuronides

Research Topics, Genomes and Genes, Scientific Experts, Publications, Species, Research Grants about glucuronides ... Summary: Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE ...

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