グルクロニド、グルクロナイド
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/03/07 15:27:37」(JST)
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Morphine-6-glucuronide, a major metabolite of morphine
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.
Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.
Examples
- Miquelianin (Quercetin 3-O-glucuronide)
- Morphine-6-glucuronide
- Scutellarein-7-glucuronide
References
- ^ The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
UpToDate Contents
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English Journal
- Alcohol hangover as a cause of impairment in apprehended drivers.
- Høiseth G1, Fosen JT, Liane V, Bogstrand ST, Mørland J.
- Traffic injury prevention.Traffic Inj Prev.2015 May 19;16(4):323-8. doi: 10.1080/15389588.2014.938324. Epub 2014 Dec 1.
- OBJECTIVE: Previous studies have already shown the possibility of impairment during a hangover phase, after alcohol ingestion, when the blood alcohol concentration has returned to zero. The prevalence of drivers being in a hangover phase, in the driving population, and the relation to impairment rel
- PMID 25023858
- The tomato sauce making process affects the bioaccessibility and bioavailability of tomato phenolics: A pharmacokinetic study.
- Martínez-Huélamo M1, Tulipani S2, Estruch R3, Escribano E4, Illán M5, Corella D6, Lamuela-Raventós RM7.
- Food chemistry.Food Chem.2015 Apr 15;173:864-72. doi: 10.1016/j.foodchem.2014.09.156. Epub 2014 Oct 18.
- Tomato sauce is the most commonly consumed processed tomato product worldwide, but very little is known about how the manufacturing process may affect the phenolic composition and bioavailability after consumption. In a prospective randomised, cross-over intervention study, we analysed the plasma an
- PMID 25466100
- Optimisation of ultrasonic-assisted extraction of phenolic compounds, antioxidants, and anthocyanins from sugar beet molasses.
- Chen M1, Zhao Y1, Yu S2.
- Food chemistry.Food Chem.2015 Apr 1;172:543-50. doi: 10.1016/j.foodchem.2014.09.110. Epub 2014 Sep 28.
- Response surface methodology was used to optimise experimental conditions for ultrasonic-assisted extraction (UAE) of functional components from sugar beet molasses. The central composite design (CCD) was used for the optimisation of extraction parameters in terms of total phenolic contents, antioxi
- PMID 25442590
Japanese Journal
- Phase-II conjugation ability for PAH metabolism in amphibians : Characteristics and inter-species differences
- Ueda Haruki,Ikenaka Yoshinori,Nakayama Shouta M. M.,Tanaka-Ueno Tomoko,Ishizuka Mayumi
- Aquatic Toxicology 105(3-4), 337-343, 2011-10
- … Identification of pyrene metabolites by HPLC and ion-trap MS system indicated that medaka mainly excreted pyrene-1-glucuronide (PYOG), while pyrene-1-sulfate (PYOS) was the main metabolite in all amphibian species. …
- NAID 120003762598
- 既存添加物酸化防止剤の製法による抗酸化能および主要成分の変動解析
- 天倉 吉章,好村 守生,吉村 文子,吉田 隆志
- 日本食品化学学会誌 18(1), 25-34, 2011-04-26
- … 精油を含む画分は抗酸化活性をほとんど示さず、極性画分に有効成分の含有が示唆されたため成分分析をしたところ、syringin(sinapyl alcohol 4-O-β-D-glucoside)およびquercetin 3-O-β-D-glucuronideが主成分として検出され、それらが高い抗酸化能を示すことを明らかにした。 …
- NAID 110008661324
Related Links
- A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. The glucuronides belong to the glycosides. Glucuronidation, the conversion of chemical ...
- Glucuronidation is the addition of glucuronic acid to a substrate. Glucuronidation is often involved in xenobiotic metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid ...
Related Pictures
![Description Codeine-6-glucuronide.svg](https://1mg.info/0/5/k/1404.jpg)
![Haworth structure for Glucuronide](https://1mg.info/0/5/k/1405.jpg)
![Description Ethyl glucuronide.svg](https://1mg.info/0/5/k/1406.jpg)
![File:Morphine-3-glucuronide.svg](https://1mg.info/0/5/k/1407.jpg)
![Description Morphine-6-glucuronide.png](https://1mg.info/0/5/k/1408.jpg)
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