- 関
- glucuronidation
English Journal
- Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.
- Hu DG1, Mackenzie PI1, McKinnon RA1, Meech R1.
- Drug metabolism reviews.Drug Metab Rev.2016 Feb 1:1-19. [Epub ahead of print]
- Identification of genetic polymorphisms that contribute to the risk of developing cancers is important for cancer prevention. The most recent human genome GRCh38/hg38 assembly (2013) reveals thousands of genetic polymorphisms in human uridine diphosphoglucuronosyltransferase (UGT) genes. Among these
- PMID 26828111
- Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family.
- Fay MJ1, Nguyen MT1, Snouwaert JN1, Dye R1, Grant DJ1, Bodnar WM1, Koller BH2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec;43(12):1838-46. doi: 10.1124/dmd.115.065482. Epub 2015 Sep 9.
- UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased water solubility to facilitate excretion. Glucuronidation repr
- PMID 26354949
- Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
- Dates CR1, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A.
- Cancer biology & therapy.Cancer Biol Ther.2015;16(5):714-23. doi: 10.1080/15384047.2015.1026480.
- Increased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulat
- PMID 25996841
Japanese Journal
- Identification of the Human UDP-glucuronosyltransferase Isoforms Involved in the Glucuronidation of the Phytochemical Ferulic Acid
- Effect of Retinoids on UDP-Glucuronosyltransferase 2B7 mRNA Expression in Caco-2 Cells
- Structure Elucidation of Novel Metabolites of Gemfibrozil in Dog : Conjugation Reaction of Conjugated Metabolites
Related Pictures
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- 関
- glucuronidate