English Journal

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

Hu DG1, Mackenzie PI1, McKinnon RA1, Meech R1.
Drug metabolism reviews.Drug Metab Rev.2016 Feb 1:1-19. [Epub ahead of print]
Identification of genetic polymorphisms that contribute to the risk of developing cancers is important for cancer prevention. The most recent human genome GRCh38/hg38 assembly (2013) reveals thousands of genetic polymorphisms in human uridine diphosphoglucuronosyltransferase (UGT) genes. Among these
PMID 26828111

Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family.

Fay MJ1, Nguyen MT1, Snouwaert JN1, Dye R1, Grant DJ1, Bodnar WM1, Koller BH2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Dec;43(12):1838-46. doi: 10.1124/dmd.115.065482. Epub 2015 Sep 9.
UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased water solubility to facilitate excretion. Glucuronidation repr
PMID 26354949

Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.

Dates CR1, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A.
Cancer biology & therapy.Cancer Biol Ther.2015;16(5):714-23. doi: 10.1080/15384047.2015.1026480.
Increased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulat
PMID 25996841

Japanese Journal

Identification of the Human UDP-glucuronosyltransferase Isoforms Involved in the Glucuronidation of the Phytochemical Ferulic Acid

Drug Metabolism and Pharmacokinetics 26(4), 341-350, 2011
NAID 130004463194

Effect of Retinoids on UDP-Glucuronosyltransferase 2B7 mRNA Expression in Caco-2 Cells

Drug Metabolism and Pharmacokinetics 23(5), 364-372, 2008
NAID 130004463037

Structure Elucidation of Novel Metabolites of Gemfibrozil in Dog : Conjugation Reaction of Conjugated Metabolites

質量分析 = Mass spectroscopy 52(1), 21-28, 2004-02-01
NAID 10011944441

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