WordNet

impatience with annoyances; "his intolerance of interruptions"
unwillingness to recognize and respect differences in opinions or beliefs
a monosaccharide sugar that has several forms; an important source of physiological energy

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〈U〉(宗教・意見・習慣の相違について)偏狭で認めないこと / 〈U〉(寒暑・痛みなどに)耐えられないこと;〈C〉過敏症
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/18 19:36:56」(JST)

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Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality.^[1]

Criteria[edit]

According to the criteria of the World Health Organization and the American Diabetes Association, impaired glucose tolerance is defined as:^[2]^[3]

two-hour glucose levels of 140 to 199 mg per dL (7.8 to 11.0 mmol) on the 75-g oral glucose tolerance test. A patient is said to be under the condition of IGT when he/she has an intermediately raised glucose level after 2 hours, but less than would qualify for type 2 diabetes mellitus. The fasting glucose may be either normal or mildly elevated.

From 10 to 15 percent of adults in the United States have impaired glucose tolerance or impaired fasting glucose.^[4]

Treatment[edit]

Main article: Prevention of diabetes mellitus type 2

The risk of progression to diabetes and development of cardiovascular disease is greater than for impaired fasting glucose.^[5]

Although some drugs can delay the onset of diabetes, lifestyle modifications play a greater role in the prevention of diabetes.^[4]^[6] Patients identified as having an IGT should exercise regularly, lose 5 to 7 percent of body weight, and limit intake of (at least) sugar and highly processed carbohydrates.^{[citation needed]} America is known to have a higher percentage of diabetes due to the average intake of sugar and high carbohydrate food consumed by the general population.

References[edit]

^ Barr EL, Zimmet PZ, Welborn TA, et al. (2007). "Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)". Circulation 116 (2): 151–7. doi:10.1161/CIRCULATIONAHA.106.685628. PMID 17576864.
^ .World Health Organization. "Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus". Retrieved 2007-05-29.
^ American Diabetes, Association (2005). "Diagnosis and classification of diabetes mellitus". Diabetes Care. 28 Suppl 1: S37–42. PMID 15618111.
^ ^a ^b Shobha S. Rao, Phillip Disraeli, Tamara McGregor (15 April 2004). "Impaired Glucose Tolerance and Impaired Fasting Glucose". American Family Physician 69 (8): 1961.
^ Oxford Handbook of Clinical Medicine, 7th Ed., Longmore, Wilkinson, Turmezei and Cheung. Oxford University Press 2007.
^ Raina Elley C, Kenealy T (December 2008). "Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance". Evid Based Med 13 (6): 173. doi:10.1136/ebm.13.6.173. PMID 19043031.

UpToDate Contents

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English Journal

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ.SourceDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
International journal of molecular medicine.Int J Mol Med.2011 Oct;28(4):589-94. doi: 10.3892/ijmm.2011.752. Epub 2011 Jul 19.
After severe burn injury and other major traumas, glucose tolerance tests demonstrate delayed glucose disposal. This 'diabetes of injury' could be explained by insulin deficiency, and several studies have shown that soon after trauma (ebb phase) insulin concentrations are reduced in the face of hype
PMID 21805045

Homeostastic and non-homeostatic functions of melanocortin-3 receptors in the control of energy balance and metabolism.

Begriche K, Sutton GM, Butler AA.SourceDepartment of Metabolism and Aging, The Scripps Research Institute-Florida, Jupiter, FL 33458, USA.
Physiology & behavior.Physiol Behav.2011 Sep 26;104(4):546-54. Epub 2011 Apr 13.
The central nervous melanocortin system is a neural network linking nutrient-sensing systems with hypothalamic, limbic and hindbrain neurons regulating behavior and metabolic homeostasis. Primary melanocortin neurons releasing melanocortin receptor ligands residing in the hypothalamic arcuate nucleu
PMID 21497617

Japanese Journal

当院人間ドックにおける非アルコール性脂肪性肝疾患と耐糖能異常の関連性

赤池淳,渡邉不二夫,平塚正幸 [他]
人間ドック = Ningen Dock : official journal of the Japanese Society of Human Dry Dock 30(1), 46-51, 2015-06
NAID 40020525989

Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fed rats

Nakajima Shingo,Hira Tohru,Hara Hiroshi
British journal of nutrition 113(9), 1477-1488, 2015-05-15
… Postprandial glucose in response to normal meal ingestion was increased in the HF/HS group within 2 weeks, and its elevation gradually returned close to that of the control group until day 50. … These results revealed that the postprandial GLP-1 response to meal ingestion is enhanced during the progression of diet-induced glucose intolerance and obesity in rats. …
NAID 120005623205