glucose 1-dehydrogenase

グルコース-1-脱水素酵素、グルコース-1-デヒドロゲナーゼ

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glucose dehydrogenase

WordNet

1. a monosaccharide sugar that has several forms; an important source of physiological energy

PrepTutorEJDIC

1. ブドウ糖

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/06 17:04:52」(JST)

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[Wiki en表示]

glucose 1-dehydrogenase
Identifiers
EC number	1.1.1.47
CAS number	9028-53-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)⁺ D-glucono-1,5-lactone + NAD(P)H + H⁺

The 3 substrates of this enzyme are beta-D-glucose, NAD⁺, and NADP⁺, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)⁺ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)⁺).

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.

References

• K, Rick W, Staudinger HJ (1975). "[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]". Z. Klin. Chem. Klin. Biochem. 13 (3): 101–7. PMID 810982.
• Brink NG; Miettinen, Jorma K.; Olsen, John; Virtanen, Artturi I.; Sörensen, Nils Andreas (1953). "Beef liver glucose dehydrogenase. 1. Purification and properties". Acta Chem. Scand. 7: 1081–1089. doi:10.3891/acta.chem.scand.07-1081.
• Pauly HE and Pfleiderer G (1976). "D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure". Hoppe-Seyler's Z. Physiol. Chem. 356 (10): 1613–1623. PMID 2530.
• Strecker HJ, Korkes S (1952). "Glucose dehydrogenase". J. Biol. Chem. 196 (2): 769–84. PMID 12981017.
• Thompson RE, Carper WR (1970). "Glucose dehydrogenase from pig liver. I. Isolation and purification". Biochim. Biophys. Acta 198 (3): 397–406. PMID 4392298.

UpToDate Contents

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• 1. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
• 2. グルコース-6-リン酸脱水素酵素欠損症の臨床症状 clinical manifestations of glucose 6 phosphate dehydrogenase deficiency
• 3. グルコース-6-リン酸脱水素酵素欠損症の遺伝学および病態生理 genetics and pathophysiology of glucose 6 phosphate dehydrogenase deficiency
• 4. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く） disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency
• 5. 幼児および小児における低血糖症の病因 etiology of hypoglycemia in infants and children

English Journal

• Accumulation of d-glucose from pentoses by metabolically engineered Escherichia coli.

• Xia T1, Han Q1, Costanzo WV1, Zhu Y1, Urbauer JL2, Eiteman MA3.
• Applied and environmental microbiology.Appl Environ Microbiol.2015 May 15;81(10):3387-94. doi: 10.1128/AEM.04058-14. Epub 2015 Mar 6.
• Escherichia coli that is unable to metabolize d-glucose (with knockouts in ptsG, manZ, and glk) accumulates a small amount of d-glucose (yield of about 0.01 g/g) during growth on the pentoses d-xylose or l-arabinose as a sole carbon source. Additional knockouts in the zwf and pfkA genes, encoding, r
• PMID 25746993

• Comparative and quantitative proteomic analysis of normal and degenerated human annulus fibrosus cells.

• Ye D1, Liang W, Dai L, Zhou L, Yao Y, Zhong X, Chen H, Xu J.
• Clinical and experimental pharmacology & physiology.Clin Exp Pharmacol Physiol.2015 May;42(5):530-6. doi: 10.1111/1440-1681.12386.
• Degeneration of the intervertebral disc (IVD) is a major chronic medical condition associated with back pain. To better understand the pathogenesis of IVD degeneration, we performed comparative and quantitative proteomic analyses of normal and degenerated human annulus fibrosus (AF) cells and identi
• PMID 25739836

• Biofuel cells based on direct enzyme-electrode contacts using PQQ-dependent glucose dehydrogenase/bilirubin oxidase and modified carbon nanotube materials.

• Scherbahn V1, Putze MT1, Dietzel B2, Heinlein T3, Schneider JJ3, Lisdat F4.
• Biosensors & bioelectronics.Biosens Bioelectron.2014 Nov 15;61:631-8. doi: 10.1016/j.bios.2014.05.027. Epub 2014 Jun 3.
• Two types of carbon nanotube electrodes (1) buckypaper (BP) and (2) vertically aligned carbon nanotubes (vaCNT) have been used for elaboration of glucose/O2 enzymatic fuel cells exploiting direct electron transfer. For the anode pyrroloquinoline quinone dependent glucose dehydrogenase ((PQQ)GDH) has
• PMID 24967753

Japanese Journal

• Activity of Glucose-6-phosphate 1-Dehydrogenase in Hair Follicles with Male-pattern Alopecia

• Adachi Kuniaki,Watanabe Yasusi,Inouye Kuniyo
• Bioscience, biotechnology, and biochemistry 63(12), 2219-2221, 1999-12-23
• … Activity of glucose-6-phosphate 1-dehydrogenase (G6PDH) in human hair follicles was measured. …
• NAID 110002679447

Related Links

• Glucose 1-dehydrogenase - 産業用酵素の受託研究開発・製造 ...

GCD-41-01 ＊Protein conc、Activity、Volume、Lot No.は変わる可能性がございます。 Data sheet Enzyme ; Glucose 1-dehydrogenase Code ; GCD -41 -01 Lot No. ; 1-H202 Protein conc. ; 10 mg/ml

• Glucose 1-dehydrogenase - Bacillus megaterium

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★リンクテーブル★

リンク元	「グルコース-1-脱水素酵素」「グルコース-1-デヒドロゲナーゼ」
関連記事	「dehydrogenase」「dehydrogenases」

「グルコース-1-脱水素酵素」

　　[★]

英

glucose 1-dehydrogenase

関

グルコース-1-デヒドロゲナーゼ

「グルコース-1-デヒドロゲナーゼ」

　　[★]

英

glucose 1-dehydrogenase

関

グルコース-1-脱水素酵素

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ