English Journal

Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol.

Calamita G, Gena P, Ferri D, Rosito A, Rojek A, Nielsen S, Marinelli RA, Frühbeck G, Svelto M.
Biology of the cell. 2012 Jun;104(6)342-51.
Lipolytic glycerol, released from adipocytes, flows through the bloodstream to the liver, where its utilisation in supplying hepatocyte gluconeogenesis is rate-limited by the permeation step. An aquaglyceroporin expressed in hepatocytes, aquaporin-9 (AQP9), has been often linked to liver uptake of g
PMID 22316404

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes.

Frescas D, Valenti L, Accili D.
The Journal of biological chemistry. 2005 May;280(21)20589-95.
Activation of NAD-dependent deacetylases, or Sirtuins, prolongs life span and mimics the effects of caloric restriction in yeast. The FoxO subfamily of forkhead transcription factors has been shown to mediate some of the effects of Sirtuins. Here we have shown that Sirtuin activation or hydrogen per
PMID 15788402

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D.
Nature genetics. 2002 Oct;32(2)245-53.
Type 2 diabetes results from impaired action and secretion of insulin. It is not known whether the two defects share a common pathogenesis. We show that haploinsufficiency of the Foxo1 gene, encoding a forkhead transcription factor (forkhead box transcription factor O1), restores insulin sensitivity
PMID 12219087

Japanese Journal

Nuclear trapping of the forkhead transcription factor FoxO1 vai Sirt-dependent deacetylation promotes expression of glucogenetic genes

J Biol Chem 280, 20589-20595, 2005
NAID 80017342058

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