English Journal
- ITA-MNGIE: an Italian regional and national survey for mitochondrial neuro-gastro-intestinal encephalomyopathy.
- D'Angelo R1, Rinaldi R2, Carelli V3,4, Boschetti E1, Caporali L3, Capristo M3, Casali C5, Cenacchi G4, Gramegna LL4, Lodi R4, Pinna AD1, Pironi L1, Stanzani M6, Tonon C4, D'Alessandro R7, De Giorgio R1.
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.Neurol Sci.2016 Jul;37(7):1149-51. doi: 10.1007/s10072-016-2552-7. Epub 2016 Mar 23.
- Mitochondrial neuro-gastro-intestinal encephalomyopathy (MNGIE) is a rare and unavoidably fatal disease due to mutations in thymidine phosphorylase (TP). Clinically it is characterized by gastrointestinal dysfunction, malnutrition/cachexia and neurological manifestations. MNGIE diagnosis remains a c
- PMID 27007276
- Evaluation of [18F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer.
- Rapic S1, Vangestel C1,2, Verhaeghe J1, Thomae D1,2, Pauwels P3,4, Van den Wyngaert T1,2, Staelens S1, Stroobants S5,6.
- Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.Mol Imaging Biol.2016 Jun 20. [Epub ahead of print]
- PURPOSE: In oncology, positron emission tomography imaging using dedicated tracers as biomarkers may assist in early evaluation of therapy efficacy. Using 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT), we investigated the early effects of chemotherapeutic treatment on cancer cell proliferation in a BR
- PMID 27324368
- TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.
- van der Velden DL1, Opdam FL2, Voest EE1.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2016 Jun 15;22(12):2835-9. doi: 10.1158/1078-0432.CCR-15-2783. Epub 2016 Apr 28.
- TAS-102 is a novel oral formulation of trifluridine (TFT) and tipiracil hydrochloride (TPI), a thymidine phosphorylase inhibitor. TFT was originally synthesized in the 1960s and is a nucleoside analogue that impedes DNA synthesis by inhibition of thymidylate synthase. TFT's main mechanism of action,
- PMID 27126991
Japanese Journal
- Diagnosis and therapy of rheumatoid arthritis in the future
- Modern rheumatology 11(4), 286-291, 2001-12-01
- NAID 50000252546
- Autocrine induction of gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) and GLS-induced expression of matrix metalloproteinases in rheumatoid arthritis synoviocytes
- Rheumatology 38, 1195-1202, 1999
- NAID 30018508483
- グリオスタチン/チミジンホスホリラーゼにより誘導されたウサギ膝滑膜炎の組織学的検討
- 日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association 72(8), S1316, 1998-08-25
- NAID 10016496020
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- Gliostatin/thymidine phosphorylase (GLS/TP) has angiogenic and arthritogenic activities, and aberrant GLS production has been observed in the active synovial membranes of rheumatoid arthritis (RA) patients. The human GLS ...
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