ゲストノロン
- 関
- gestonorone caproate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/31 01:01:56」(JST)
[Wiki en表示]
Gestonorone
|
Systematic (IUPAC) name |
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
Clinical data |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
ATC code |
G03DA01 L02AB03 |
PubChem |
CID 102210 |
ChemSpider |
92341 Y |
UNII |
H4G605B7VP Y |
Chemical data |
Formula |
C20H28O3 |
Mol. mass |
316.435 g/mol |
SMILES
- O=C4\C=C2/[C@@H]([C@H]1CC[C@@]3([C@@](O)(C(=O)C)CC[C@H]3[C@@H]1CC2)C)CC4
|
InChI
-
InChI=1S/C20H28O3/c1-12(21)20(23)10-8-18-17-5-3-13-11-14(22)4-6-15(13)16(17)7-9-19(18,20)2/h11,15-18,23H,3-10H2,1-2H3/t15-,16+,17+,18-,19-,20-/m0/s1 Y
Key:GTFUITFQDGVJSK-XGXHKTLJSA-N Y
|
Y (what is this?) (verify)
|
Gestonorone (or 17-nydroxy-19-norprogesterone) is a steroidal progestin.
References
Estrogens and progestogens (G03C-D, L02)
|
|
Progestogens |
Agonist |
1st |
- Norpregnene
- Norethisterone#/Norethisterone acetate
- Etynodiol diacetate
|
|
2nd |
- Norpregnene
- Levonorgestrel#/Norgestrel/Norelgestromin
|
|
3rd |
- 19-Nortestosterone
- Desogestrel/Etonogestrel
- Gestodene
- Norgestimate
|
|
4th |
- Androstene
- 19-Norprogesterone
- Nomegestrol acetate
- Promegestone
- Trimegestone
- 19-Nortestosterone
|
|
17-OH |
- Chlormadinone acetate
- Cyproterone acetate
- Medroxyprogesterone acetate#
- Megestrol acetate
|
|
Other/
ungrouped |
- Pregnenedione
- Pregnene
- Pregnadiene
- Norpregnane
- Lynestrenol
- Norethynodrel
- Tibolone
- Dydrogesterone
- Quingestanol
|
|
|
Antiprogestogens/
SPRMs |
- Antagonists
- Aglepristone
- Mifepristone
- Asoprisnil
- Telapristone
- Ulipristal acetate
|
|
|
Estrogens |
Agonists |
Steroidal |
- Diosgenin
- Estetrol
- Estradiol
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate#
- Estradiol dipropionate
- Estradiol enanthate
- Estradiol hemihydrate
- Estradiol undecylate
- Estradiol valerate
- Polyestradiol phosphate
- Estriol
- Estrone
- Estriol
- Ethinylestradiol#
- Promestriene
- Equilenin
- Equilin
|
|
Nonsteroidal |
- Chlorotrianisene
- Dienestrol
- Fosfestrol
- Diethylstilbestrol
- Zeranol
|
|
|
Antiestrogens/
SERMs |
- Afimoxifene
- Arzoxifene
- Bazedoxifene
- Clomifene#
- Cyclofenil
- Epimestrol
- Lasofoxifene
- Mepitiostane
- Nafoxidine
- Ormeloxifene
- Raloxifene
- Tamoxifen
- Toremifene
- Pure antagonists: Fulvestrant
|
|
Aromatase inhibitors |
- Nonselective
- Aminoglutethimide
- Testolactone
- Selective
- Anastrozole
- Atamestane
- Exemestane
- Fadrozole
- Formestane
- Letrozole
- Minamestane
- Plomestane
- Vorozole
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
noco/cong/npls, sysi/epon
|
proc/asst, drug (G1/G2B/G3CD)
|
|
|
|
Progestogenics
|
|
Receptor |
|
|
Enzyme
(inhibitors) |
20,22-Desmolase
|
- 22-ABC
- 3,3′-Dimethoxybenzidine
- 3-Methoxybenzidine
- Aminoglutethimide
- Cyanoketone
- Danazol
- Etomidate
- Mitotane
- Trilostane
|
|
17α-Hydroxylase,
17,20-Lyase
|
- 22-ABC
- 22-Oxime
- Abiraterone
- Bifonazole
- Clotrimazole
- Cyanoketone
- Cyproterone acetate
- Danazol
- Econazole
- Galeterone
- Gestrinone
- Isoconazole
- Ketoconazole
- L-39
- Levonorgestrel
- Liarozole
- LY-207,320
- MDL-27,302
- Miconazole
- Mifepristone
- Orteronel
- Pioglitazone
- Rosiglitazone
- Spironolactone
- Stanozolol
- SU-10,603
- TGF-β
- Tioconazole
- Troglitazone
- VN/87-1
- YM116
|
|
3β-HSD
|
- 4-MA
- Azastene
- Cyanoketone
- Danazol
- Epostane
- Genistein
- Gestrinone
- Metyrapone
- Norethisterone
- Oxymetholone
- Pioglitazone
- Rosiglitazone
- Trilostane
- Troglitazone
|
|
21-Hydroxylase
|
- Aminoglutethimide
- Amphenone B
- Bifonazole
- Clotrimazole
- Diazepam
- Econazole
- Genistein
- Isoconazole
- Ketoconazole
- Metyrapone
- Miconazole
- Midazolam
- Tioconazole
|
|
|
Other |
Endogenous
|
- Progestogens: Deoxycorticosterone
- 17-Hydroxyprogesterone
- Progesterone
- Precursors: Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- 17-Hydroxypregnenolone
|
|
Indirect
|
- Androgens/Antiandrogens (see here)
- Estrogens/Antiestrogens (see here)
- GnRH agonists/antagonists (see here)
- Gonadotropins/Antigonadotropins (see here)
- Plasma proteins (Transcortin, Albumin)
|
|
Procedures
|
- Adrenalectomy
- Hypophysectomy
- Oophorectomy
- Orchiectomy
|
|
|
English Journal
- Cyproterone synthesis, recognition and controlled release by molecularly imprinted nanoparticle.
- Asadi E1, Azodi-Deilami S, Abdouss M, Khaghani S.
- Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2012 Aug;167(7):2076-87. doi: 10.1007/s12010-012-9748-y. Epub 2012 Jun 5.
- In this study, we used novel synthetic conditions of precipitation polymerization to obtain nanosized cyproterone molecularly imprinted polymers for application in the design of new drug delivery systems. The scanning electron microscopy images and Brunauer-Emmett-Teller analysis showed that molecul
- PMID 22669687
- Progestins for the prevention of spontaneous preterm birth: review and implications of recent studies.
- O'Brien JM1, Lewis DF.
- The Journal of reproductive medicine.J Reprod Med.2009 Feb;54(2):73-87.
- Progesterone plays a central role in the mechanisms of parturition in many species. Despite remarkable advances in our understanding of this hormone's mechanism of action, its roles in human pregnancy maintenance and parturition are not fully appreciated. Proper scientific hypothesis testing of prog
- PMID 19301570
- Preterm birth prevention by 17 alpha-hydroxyprogesterone caproate vs. daily nursing surveillance.
- Rittenberg C1, Newman RB, Istwan NB, Rhea DJ, Stanziano GJ.
- The Journal of reproductive medicine.J Reprod Med.2009 Feb;54(2):47-52.
- OBJECTIVE: To compare the incidence of spontaneous recurrent preterm delivery (SPTD) between women receiving 17 alpha-hydroxyprogesterone caproate (17P) and women receiving daily perinatal nursing surveillance (dPNS) with home uterine activity monitoring.STUDY DESIGN: Women enrolled for dPNS or week
- PMID 19301566
Japanese Journal
- 前立腺肥大症に対する抗アンドロゲン療法 : 薬剤の紹介と臨床成績
- 蟹本 雄右,岡田 謙一郎
- 泌尿器科紀要 37(11), 1423-1428, 1991-11
- … The progestational agents such as gestonorone caproate, chlormadinone acetate and allylestrenol suppress more or less sexual function by interference of the pituitary-gonadal axis. …
- NAID 120002158078
- 前立腺超音波計測6年間の経験 : 第3報 : 肥大症前立腺重量の抗アンドロゲン療法による変化
- 林田 真和,木村 明,樋口 照男
- 日本泌尿器科學會雜誌 77(9), 1467-1477, 1986-09-20
- … gestonorone caproate=GC投与例7例).以上105例の前立腺重量の経時的変化を検討することにより,以下の知見を得た.1)CMA投与例98例中85例,GC投与例7例中6例に前立腺重量の縮小が見られた.縮小率の平均は各々31.7%及び20.7%であった.2)CMA投与中止後まで経過観察された25例では,前立腺重量平均はCMA投与後約4ヵ月で有意に縮少したが,CMA投与中止約1年後までに,投与前値レベルまで再増大を示した.3)上記25例中CMAの再投与を受けた16例では, …
- NAID 110003066032
- 前立腺肥大症に対するDepostat(Gestonorone Caproate,SH-582)の臨床効果-4-
Related Links
- This site is part of a network of marketers and affiliates specializing in the sales and marketing of health and wellness products derived from industrial hemp. These products range from hemp shampoo, hemp lotion, hemp based CBD ...
- This site is part of a network of marketers and affiliates specializing in the sales and marketing of health and wellness products derived from industrial hemp. These products range from hemp shampoo, hemp lotion, hemp based CBD ...
Related Pictures
★リンクテーブル★
[★]
- 英
- gestonorone、gestonorone caproate
- 関
- カプロン酸ゲストノロン
[★]
- 関
- gestonorone