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1. 胃癌の危険因子 risk factors for gastric cancer
2. 胃癌の臨床的特徴、診断、および病期分類 clinical features diagnosis and staging of gastric cancer
3. 早期胃癌：疫学、臨床症状、診断、および病期分類 early gastric cancer epidemiology clinical manifestations diagnosis and staging
4. 胃癌スクリーニングおよび予防 screening and prevention of gastric cancer
5. 遺伝性のびまん性胃癌 hereditary diffuse gastric cancer

Netazepide, a gastrin/CCK2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis.

Boyce M1, Moore AR2, Sagatun L3, Parsons BN2, Varro A2, Campbell F4, Fossmark R3, Waldum HL3, Pritchard DM2.
British journal of clinical pharmacology.Br J Clin Pharmacol.2016 Oct 4. doi: 10.1111/bcp.13146. [Epub ahead of print]
AIMS: Netazepide, a gastrin/CCK2 receptor antagonist, once daily for 12 weeks reduced the number of tumours and size of the largest one in 16 patients with autoimmune chronic atrophic gastritis (CAG), achlorhydria, hypergastrinaemia and multiple gastric neuroendocrine tumours (type 1 gastric NETs)
PMID 27704617

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.

Calvete O1, Varro A2, Pritchard DM2, Barroso A3, Oteo M4, Morcillo MÁ4, Vargiu P5, Dodd S2, Garcia M6, Reyes J7, Ortega S8, Benitez J9.
Disease models & mechanisms.Dis Model Mech.2016 Sep 1;9(9):975-84. doi: 10.1242/dmm.025890. Epub 2016 Aug 4.
By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification. This mutation causes an aggressive familial type I gastric neuroendocrine tumor in homozygous individuals. Affected individual
PMID 27491072

Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Chey WY1, Frankel WL, Roy S, Datta S, Sen CK, Dillhoff M, Muscarella P, Soergel KH, Tompkins RK, Chang TM, Bradley EL 3rd, Ellison EC.
Annals of surgery.Ann Surg.2016 Aug 5. [Epub ahead of print]
OBJECTIVES: To document the existence of primary pancreatic secretinoma in patients with watery diarrhea syndrome (WDS) and achlorhydria and establish secretin as a diarrheogenic hormone.BACKGROUND: Vasoactive intestinal peptide (VIP) has been widely accepted as the main mediator of WDS. However, in
PMID 27501174