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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/02 17:56:01」(JST)
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| Gastric antral vascular ectasia | |
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Endoscopic image of gastric antral vascular ectasia seen as a radial pattern around the pylorus before (top) and after (bottom) treatment with argon plasma coagulation
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| Classification and external resources | |
| ICD-10 | K31.88 |
| ICD-9 | 537.82 |
| DiseasesDB | 29505 |
| MeSH | D020252 |
Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron deficiency anemia.[1][2] The condition is associated with dilated small blood vessels in the antrum, or the last part of the stomach.[1] The dilated vessels result in intestinal bleeding.[3] It is also called watermelon stomach because streaky long red areas that are present in the stomach may resemble the markings on watermelon.[1][2][3][4]
The condition was first discovered in 1952,[2] and reported in the literature in 1953.[5] Watermelon disease was first diagnosed by Wheeler et al. in 1979, and definitively described in four living patients by Jabbari et al. only in 1984.[4] As of 2011, the etiology and pathogenesis are still not known.[4][6] However, there are several competing hypotheses as to various causes.[4]
Contents
- 1 Signs and symptoms
- 2 Cause
- 2.1 Associated conditions
- 3 Pathogenesis
- 4 Diagnosis
- 4.1 Differential diagnosis
- 5 Treatment and prognosis
- 5.1 Traditional treatments
- 5.2 Medications
- 5.3 Treatment of co-morbid conditions
- 5.4 Surgery
- 6 Epidemiology
- 7 References
- 8 External links
Signs and symptoms
Most patients who are eventually diagnosed with watermelon stomach come to a physician complaining of anemia and blood loss.[7] Sometimes, a patient may come to the physician because he or she notices blood in the stools — either melena (black and tarry stools) and/or hematochezia (red bloody stools).[7]
Cause
The literature, from 1953 through 2010, often cited that thecause of gastric antral vascular ectasia is unknown.[4][6][7] The causal connection between cirrhosis and GAVE has not been proven.[6] A connective tissue disease has been suspected in some cases.[7]
Autoimmunity may have something to do with it,[8] as 25% of all sclerosis patients who had a certain anti-RNA marker have GAVE.[9] RNA autoimmunity has been suspected as a cause or marker since at least 1996.[8] Gastrin levels may indicate a hormonal connection.[6]
Associated conditions
Micrograph showing liver cirrhosis, a condition that often precedes hepatic encephalopathy. Trichrome stain.
GAVE is associated with a number of conditions, including portal hypertension, chronic kidney failure, and collagen vascular diseases.[2][10]
Watermelon stomach also occurs particularly with scleroderma,[2][11][12][13] and especially the subtype known as systemic sclerosis.[2][9] A full 5.7% of persons with sclerosis have GAVE, and 25% of all sclerosis patients who had a certain anti-RNA marker have GAVE.[9] In fact:
Most patients with GAVE suffer from liver cirrhosis, autoimmune disease, chronic renal failure and bone marrow transplantation. The typical initial presentations range from occult bleeding causing transfusion-dependent chronic iron-deficiency anemia to severe acute gastrointestinal bleeding.
—Masae Komiyama, et al., 2010.[10]
The endoscopic appearance of GAVE is similar to portal hypertensive gastropathy, but is not the same condition, and may be concurrent with cirrhosis of the liver.[2][6][14][15] 30% of all patients have cirrhosis associated with GAVE.[6]
Sjögren's syndrome has been associated with at least one patient.[16]
The first case of ectopic pancreas associated with watermelon stomach was reported in 2010.[4]
Patients with GAVE may have elevated gastrin levels.[6]
The Genetic and Rare Diseases Information Center (GARD) states that pernicious anemia is one of the conditions associated with GAVE's,[17] and one separate study showed that over three-fourths of the patients in the study with GAVE's had some kind of Vitamin B12 deficiency including the associated condition pernicious anemia.[18]
Intestinal permeability and diverticulitis may occur in some patients with GAVE.
Pathogenesis
GAVE is characterized by dilated capillaries in the lamina propria with fibrin thrombi. The main histomorphologic differential diagnosis is portal hypertension, which is often apparent from clinical findings.
Research in 2010 has shown that anti-RNA polymerase III antibodies may be used as a risk marker for GAVE in systemic sclerosis patients.[9]
Diagnosis
Micrograph showing gastric antral vascular ectasia. A large spherical, eosinophilic (i.e. pink) fibrin thrombus is seen off-center right. Stomach biopsy. H&E stain.
GAVE is usually diagnosed definitively by means of an endoscopic biopsy.[6][7][10][19] The tell-tale watermelon stripes show up during the endoscopy.[7]
Surgical exploration of the abdomen may be needed to diagnose some cases, especially if the liver or other organs are involved.[4]
Differential diagnosis
GAVE results in intestinal bleeding similar to duodenal ulcers and portal hypertension.[3][6] The GI bleeding can result in anemia.[6][7] It is often overlooked, but can be more common in elderly patients.[3][7] It has been seen in a female patient of 26 years of age.[6]
Watermelon stomach has a different etiology and has a differential diagnosis from portal hypertension.[6][14] In fact, cirrhosis and portal hypertension may be missing in a patient with GAVE.[6] The differential diagnosis is important because treatments are different.[3][6][7][10]
Treatment and prognosis
Traditional treatments
GAVE is treated commonly by means of an endoscope, including argon plasma coagulation and electrocautery.[6][7][20] Since endoscopy with argon photocoagulation is "usually effective", surgery is "usually not required."[7] Coagulation therapy is well-tolerated but "tends to induce oozing and bleeding."[7] "Endoscopy with thermal ablation" is favored medical treatment because of its low side effects and low mortality, but is "rarely curative."[6]
Medications
Other medical treatments have been tried and include estrogen and progesterone therapy,[20] Corticostreoids are effective, but are "limited by their side effects."[7]
Treatment of co-morbid conditions
A transjugular intrahepatic portosystemic shunt (TIPS or TIPSS) procedure is used to treat portal hypertension when that is present as an associated condition. Unfortunately, the TIPSS, which has been used for similar conditions, may cause or exacerbate hepatic encephalopathy.[21][22] TIPSS-related encephalopathy occurs in about 30% of cases, with the risk being higher in those with previous episodes of encephalopathy, higher age, female sex, and liver disease due to causes other than alcohol.[23] The patient, with his or her physician and family, must balance out a reduction in bleeding caused by TIPS with the significant risk of encephalopathy.[21][22][23] Various shunts have been shown in a meta-study of 22 studies to be effective treatment to reduce bleeding, yet none have any demonstrated survival advantage.[21]
If there is cirrhosis of the liver that has progressed to liver failure, then lactulose may be prescribed for hepatic encephalopathy, especially for Type C encephalopathy with diabetes.[23] Also, "antibiotics such as neomycin, metronidazole, and rifaximin" may be used effectively to treat the encephalopathy by removing nitrogen-producing bacteria from the gut.[23]
Paracentesis, a medical procedure involving needle drainage of fluid from a body cavity,[24] may be used to remove fluid from the peritoneal cavity in the abdomen for such cases.[22] This procedure uses a large needle, similar to the better-known amniocentesis.
Surgery
Surgery, consisting of excision of part of the lower stomach, also called antrectomy, is another option.[6][15] Antrectomy is "the resection, or surgical removal, of a part of the stomach known as the antrum."[2] Laparoscopic surgery is possible in some cases, and as of 2003, was a "novel approach to treating watermelon stomach."[25]
A treatment used sometimes is endoscopic band ligation.[26]
In 2010, a team of Japanese surgeons performed a "novel endoscopic ablation of gastric antral vascular ectasia."[10] The experimental procedure resulted in "no complications."[10]
Relapse is possible, even after treatment by argon plasma coagulation and progesterone.[20]
Antrectomy or other surgery is used as a last resort for GAVE.[2][6][7][14][10][15]
Epidemiology
The average age of diagnosis for GAVE is 73 years of age for females,[3][7] and 68 for males.[2] Women are about twice as often diagnosed with gastric antral vascular ectasia than men.[2][7] 71% of all cases of GAVE are diagnosed in females.[3][7] Patients in their thirties have been found to have GAVE.[6] It becomes more common in women in their eighties, rising to 4% of all such gastrointestinal conditions.[10]
5.7% of all sclerosis patients (and 25% of those who had a certain anti-RNA marker) have GAVE.[9]
References
- ^ a b c Suit, PF; Petras, RE; Bauer, TW; Petrini Jr, JL (1987). "Gastric antral vascular ectasia. A histologic and morphometric study of "the watermelon stomach"". The American journal of surgical pathology 11 (10): 750–7. doi:10.1097/00000478-198710000-00002. PMID 3499091.
- ^ a b c d e f g h i j k Surgery Encyclopedia website page on Antrectomy. Accessed September 29, 2010.
- ^ a b c d e f g Nguyen, Hien; Le, Connie; Nguyen, Hanh (2009). "Gastric antral vascular ectasia (watermelon stomach)-an enigmatic and often-overlooked cause of gastrointestinal bleeding in the elderly". The Permanente journal 13 (4): 46–9. PMC 2911825. PMID 20740102.
- ^ a b c d e f g Yildiz, Baris; Sokmensuer, Cenk; Kaynaroglu, Volkan (2010). "Chronic anemia due to watermelon stomach". Annals of Saudi Medicine 30 (2): 156–8. doi:10.4103/0256-4947.60524. PMC 2855069. PMID 20220268.
- ^ Rider, JA; Klotz, AP; Kirsner, JB (1953). "Gastritis with veno-capillary ectasia as a source of massive gastric hemorrhage". Gastroenterology 24 (1): 118–23. PMID 13052170.
- ^ a b c d e f g h i j k l m n o p q r s Tuveri, Massimiliano; Borsezio, Valentina; Gabbas, Antonio; Mura, Guendalina (2007). "Gastric antral vascular ectasia—an unusual cause of gastric outlet obstruction: report of a case". Surgery today 37 (6): 503–5. doi:10.1007/s00595-006-3430-3. PMID 17522771.
- ^ a b c d e f g h i j k l m n o p q Rosenfeld, G; Enns, R (2009). "Argon photocoagulation in the treatment of gastric antral vascular ectasia and radiation proctitis". Canadian Journal of Gastroenterology 23 (12): 801–4. PMC 2805515. PMID 20011731.
- ^ a b Valdez, BC; Henning, D; Busch, RK; Woods, K; Flores-Rozas, H; Hurwitz, J; Perlaky, L; Busch, H (1996). "A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease". Nucleic Acids Research 24 (7): 1220–4. doi:10.1093/nar/24.7.1220. PMC 145780. PMID 8614622.
- ^ a b c d e Ceribelli, A; Cavazzana, I; Airò, P; Franceschini, F (2010). "Anti-RNA polymerase III antibodies as a risk marker for early gastric antral vascular ectasia (GAVE) in systemic sclerosis". The Journal of rheumatology 37 (7): 1544. doi:10.3899/jrheum.100124. PMID 20595295.
- ^ a b c d e f g h Komiyama, Masae; Fu, K; Morimoto, T; Konuma, H; Yamagata, T; Izumi, Y; Miyazaki, A; Watanabe, S (2010). "A novel endoscopic ablation of gastric antral vascular ectasia". World Journal of Gastrointestinal Endoscopy 2 (8): 298–300. doi:10.4253/wjge.v2.i8.298. PMC 2999147. PMID 21160630.
- ^ Scleroderma Association website. Accessed September 29, 2010.
- ^ Marie, I.; Ducrotte, P.; Antonietti, M.; Herve, S.; Levesque, H. (2008). "Watermelon stomach in systemic sclerosis: its incidence and management". Alimentary Pharmacology & Therapeutics 28 (4): 412. doi:10.1111/j.1365-2036.2008.03739.x.
- ^ Ingraham, KM; O'Brien, MS; Shenin, M; Derk, CT; Steen, VD (2010). "Gastric antral vascular ectasia in systemic sclerosis: demographics and disease predictors". The Journal of rheumatology 37 (3): 603–7. doi:10.3899/jrheum.090600. PMID 20080908.
- ^ a b c Spahr, L; Villeneuve, J-P; Dufresne, M-P; Tasse, D; Bui, B; Willems, B; Fenyves, D; Pomier-Layrargues, G (1999). "Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension". Gut 44 (5): 739–42. doi:10.1136/gut.44.5.739. PMC 1727493. PMID 10205216.
- ^ a b c Spahr, L; Villeneuve, JP; Dufresne, MP; Tassé, D; Bui, B; Willems, B; Fenyves, D; Pomier-Layrargues, G (1999). "Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension". Gut 44 (5): 739–42. doi:10.1136/gut.44.5.739. PMC 1727493. PMID 10205216.
- ^ Krstić, M; Alempijević, T; Andrejević, S; Zlatanović, M; Damjanov, N; Ivanović, B; Jovanović, I; Tarabar, D; Milosavljević, T (2010). "Watermelon stomach in a patient with primary Sjögren's syndrome". Vojnosanitetski pregled. Military-medical and pharmaceutical review 67 (3): 256–8. doi:10.2298/VSP1003256K. PMID 20361704.
- ^ "Watermelon Stomach"Genetic and Rare Diseases Information Center (GARD), National Institution of Health.
- ^ "Watermelon Stomach and Radiiation Proctopathy CCS Publishing, August 1, 2011
- ^ Gilliam, John H.; Geisinger, Kim R.; Wu, Wallace C.; Weidner, Noel; Richter, Joel E. (1989). "Endoscopic biopsy is diagnostic in gastric antral vascular ectasia". Digestive Diseases and Sciences 34 (6): 885–8. doi:10.1007/BF01540274. PMID 2721320.
- ^ a b c Shibukawa, G; Irisawa, A; Sakamoto, N; Takagi, T; Wakatsuki, T; Imamura, H; Takahashi, Y; Sato, A et al. (2007). "Gastric antral vascular ectasia (GAVE) associated with systemic sclerosis: relapse after endoscopic treatment by argon plasma coagulation". Internal medicine (Tokyo, Japan) 46 (6): 279–83. doi:10.2169/internalmedicine.46.6203. PMID 17379994.
- ^ a b c Khan S, Tudur Smith C, Williamson P, Sutton R (2006). Khan, Saboor A, ed. "Cochrane Database of Systematic Reviews". Cochrane Database Syst Rev (4): CD000553. doi:10.1002/14651858.CD000553.pub2. PMID 17054131.
|chapter=ignored (help) - ^ a b c Saab S, Nieto JM, Lewis SK, Runyon BA (2006). Saab, Sammy, ed. "TIPSS versus paracentesis for cirrhotic patients with refractory ascites". Cochrane Database Syst Rev (4): CD004889. doi:10.1002/14651858.CD004889.pub2. PMID 17054221.
|chapter=ignored (help) - ^ a b c d Sundaram V, Shaikh OS (July 2009). "Hepatic encephalopathy: pathophysiology and emerging therapies". Med. Clin. North Am. 93 (4): 819–36, vii. doi:10.1016/j.mcna.2009.03.009. PMID 19577116.
- ^ "paracentesis" at Dorland's Medical Dictionary
- ^ Sherman, V; Klassen, DR; Feldman, LS; Jabbari, M; Marcus, V; Fried, GM (2003). "Laparoscopic antrectomy: a novel approach to treating watermelon stomach". Journal of the American College of Surgeons 197 (5): 864–7. doi:10.1016/S1072-7515(03)00600-8. PMID 14585429.
- ^ Wells, C; Harrison, M; Gurudu, S; Crowell, M; Byrne, T; Depetris, G; Sharma, V (2008). "Treatment of gastric antral vascular ectasia (watermelon stomach) with endoscopic band ligation". Gastrointestinal Endoscopy 68 (2): 231–6. doi:10.1016/j.gie.2008.02.021. PMID 18533150.
External links
- Thonhofer, R; Siegel, C; Trummer, M; Gugl, A (2010). "Clinical images: Gastric antral vascular ectasia in systemic sclerosis". Arthritis and rheumatism 62 (1): 290. doi:10.1002/art.27185. PMID 20039398.
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English Journal
- [Severe eosinophilia in a patient with clostridium colitis and gastric cancer].
- Holub M1, Arientová S, Kořínková M, Reisingerová M, Marešová V.
- Klinická mikrobiologie a infekc̆ní lékar̆ství.Klin Mikrobiol Infekc Lek.2013 Mar;19(1):11-4.
- A case of a 77-year-old male repeatedly hospitalized with the diagnosis of Clostridium difficile colitis associated with eosinophilia is presented. The percentage and number of eosinophils achieved maximal values (54 %, 5.4 times 1.000.000.000/l) during repeated treatment with metronidazole. Eosinop
- PMID 23945831
- Portal vein gas due to gangrenous cholecystitis treated by a laparoscopic procedure: report of a case.
- Napolitano L1, Waku M, Costantini R, Mazahreh T, Innocenti P.
- Surgery today.Surg Today.2009;39(10):909-12. doi: 10.1007/s00595-008-3936-y. Epub 2009 Sep 27.
- Portal pneumatosis is a rare diagnostic factor, which is often associated with ischemic intestinal accidents. It has been associated with a negative prognosis for a very long time, and the presence of portal pneumatosis is usually an indication for the need to perform a laparotomy. A 68-year-old mal
- PMID 19784734
- [Treatment of acute gastrectasia following liver transplantation with the therapeutic methods of integrated traditional Chinese and western medicine: a report of one case].
- Fu HL1, Wei PK.
- Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.Zhong Xi Yi Jie He Xue Bao.2003 May;1(1):53.
- PMID 15339619
Japanese Journal
- 瘢痕性幽門狭窄による嘔吐で発症した食道破裂の1例
- 日本臨床外科学会雑誌 73(4), 827-831, 2012
- NAID 130004518292
- 小児胃軸捻転症に対する臍内弧状切開による胃固定術の1例
- 日本小児外科学会雑誌 44(5), 723-727, 2008-08-20
- NAID 110006863503
- 無動無言状態の著明な非定型初老期痴呆症の1剖検例
- 日本老年医学会雑誌 15(6), 587-592, 1978
- NAID 130003651280
Related Links
- Con il termine gastrectasia ci si riferisce ad un aumento di dimensioni, una dilatazione spesso acuta dello stomaco, il quale va incontro ad un improvviso aumento della sua capacità volumetrica.
- an abnormal dilation of the stomach that may be accompanied by pain, vomiting, rapid pulse, and falling body temperature. Causes include overeating, obstruction of the pyloric valve, or a hernia.
Related Pictures
★リンクテーブル★
| リンク元 | 「胃拡張」「gastrectasis」「gastric dilation」「gastric dilatation」 |