γリ・トロピン

WordNet

a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
the 3rd letter of the Greek alphabet
a herd of whales

PrepTutorEJDIC

ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
(特に女性の)魅力的な脚,すんなりした脚

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2020/06/01 14:40:56」(JST)

wiki en

Lipotropin is the name for two hormones produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which is then cleaved again to form adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).

β-Lipotropin

β-Lipotropin is a 90-amino acid polypeptide that is the carboxy-terminal fragment of POMC. It was initially reported to stimulate melanocytes to produce melanin. It was also reported to perform lipid-mobilizing functions such as lipolysis^[1] and steroidogenesis. However, no subsequent studies have been published that support these early findings and no receptor has been identified for β-lipotropin.

β-Lipotropin can be cleaved into smaller peptides. In humans, γ-lipotropin, β-MSH, and β-endorphin, are all possible fragments of β-lipotropin.^[2] β-Lipotropin is the predominant opioid of the anterior human and rat pituitary gland. It is found in essentially equimolar concentrations to that of corticotropin. Evidence shows that β-Lipotropin is metabolized into endorphins that can greatly affect mood and behavior and is thus regarded as a prohormone.^[3]

γ-Lipotropin

γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids. Gamma lipotropin is identical to the first 56 amino acid sequences of β-lipotropin. It can be cleaved to β-melanocyte stimulating hormone.

Use in sport

Lipotropin has also, under its alternate name AOD-9604 (Anti-Obesity Drug-9604),^[4] been connected with controversies in Australian Rules Football. Allegations have arisen around the use of the drug and its administration to players of the Essendon Football Club as a supplement, including weekly administration to players in the 2012 season. The matters are currently under investigation due to the relationship between Lipotropin and growth hormones, as noted by club medical staff.^[5]

References

^ Li CH, Chung D (April 1976). "Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1145–8. Bibcode:1976PNAS...73.1145L. doi:10.1073/pnas.73.4.1145. PMC 430217. PMID 1063395.
^ Spiess J, Mount CD, Nicholson WE, Orth DN (August 1982). "NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed sequences". Proceedings of the National Academy of Sciences of the United States of America. 79 (16): 5071–5. Bibcode:1982PNAS...79.5071S. doi:10.1073/pnas.79.16.5071. PMC 346829. PMID 6956916.
^ Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins". Proceedings of the National Academy of Sciences of the United States of America. 73 (6): 2156–9. Bibcode:1976PNAS...73.2156L. doi:10.1073/pnas.73.6.2156. PMC 430469. PMID 1064883.
^ Peptides Direct information page, accessed 26 August 2013
^ AFL Statement of Charges against James Hird and Essendon Football Club, accessed 26 August 2013 [1]

External links

beta-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH)
gamma-Lipotropin at the US National Library of Medicine Medical Subject Headings (MeSH)

This molecular biology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ACTH、CRH、および他の視床下部／下垂体ペプチドの測定 measurement of acth crh and other hypothalamic and pituitary peptides
2. ビタミンKおよびその合成ならびにガンマカルボキシグルタミン酸の機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
3. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-グルタミルトランスペプチダーゼなど） enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase
4. ガンマヒドロキシブチレート（GHB）中毒 gamma hydroxybutyrate ghb intoxication
5. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects

English Journal

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9).

Chrétien M1, Mbikay M2.
Journal of molecular endocrinology.J Mol Endocrinol.2016 May;56(4):T49-62. doi: 10.1530/JME-15-0261. Epub 2016 Jan 13.
PMID 26762158

Imaging and identification of endogenous peptides from rat pituitary embedded in egg yolk.

Sosnowski P1, Zera T2, Wilenska B1, Szczepanska-Sadowska E2, Misicka A1,3.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2015 Feb 28;29(4):327-35. doi: 10.1002/rcm.7112.
PMID 26406344

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin.

Höftberger R1, Kunze M, Voigtländer T, Unterberger U, Regelsberger G, Bauer J, Aboul-Enein F, Garzuly F, Forss-Petter S, Bernheimer H, Berger J, Budka H.
Endocrinology.Endocrinology.2010 Oct;151(10):4801-10. doi: 10.1210/en.2010-0249. Epub 2010 Sep 1.
PMID 20810565

「γリポトロピン」

pro-opiomelanocortin
Identifiers
Symbol	POMC
NCBI gene	5443
HGNC	9201
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Other data
Locus	Chr. 2 p23

　　[★]

英: gamma-lipotropin
関: リポトロピン

「gamma」

　　[★] γ ガンマ　　　

[1] Li CH, Chung D (April 1976). "Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1145–8. Bibcode:1976PNAS...73.1145L. doi:10.1073/pnas.73.4.1145. PMC 430217. PMID 1063395.

[2] Spiess J, Mount CD, Nicholson WE, Orth DN (August 1982). "NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed sequences". Proceedings of the National Academy of Sciences of the United States of America. 79 (16): 5071–5. Bibcode:1982PNAS...79.5071S. doi:10.1073/pnas.79.16.5071. PMC 346829. PMID 6956916.

[3] Lazarus LH, Ling N, Guillemin R (June 1976). "beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins". Proceedings of the National Academy of Sciences of the United States of America. 73 (6): 2156–9. Bibcode:1976PNAS...73.2156L. doi:10.1073/pnas.73.6.2156. PMC 430469. PMID 1064883.

[4] Peptides Direct information page, accessed 26 August 2013

[5] AFL Statement of Charges against James Hird and Essendon Football Club, accessed 26 August 2013 [1]

匿名

検索

案内

案内

gamma-lipotropin