WordNet

capable of serving a purpose well; "software with greater functionality"
relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis"
fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order" (同)usable, useable, operable, operational
designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture"
designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture"
involving or affecting function rather than physiology; "functional deafness"

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『機能上の』 / (余分なものが無く)機能的な,実用的な / (数学で)関数の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/13 05:14:20」(JST)

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1. 膵神経内分泌腫瘍（膵島細胞腫瘍）の分類、疫学、臨床症状、局在、および病期分類 classification epidemiology clinical presentation localization and staging of pancreatic neuroendocrine tumors islet cell tumors
2. 着用型除細動器 wearable cardioverter defibrillator
3. 散発性膵神経内分泌腫瘍の外科的切除 surgical resection of sporadic pancreatic neuroendocrine tumors
4. 消化器における神経内分泌腫瘍の発生の病理、分類、および重症度分類 pathology classification and grading of neuroendocrine tumors arising in the digestive system
5. リポ蛋白および止血因子に対する運動の影響 effects of exercise on lipoproteins and hemostatic factors

English Journal

CHEMICAL MODIFICATION OF L-ASPARAGINASE FROM Cladosporium sp. FOR IMPROVED ACTIVITY AND THERMAL STABILITY.

Mohan Kumar NS, Kishore V, Manonmani HK.Author information a Fermentation Technology and Bioengineering Department , Central Food Technological Research Institute (CFTRI) , Mysore , India.AbstractL-Asparaginase (ASNase), an antileukemia enzyme, is facing problems with antigenicity in the blood. Modification of L-asparaginase from Cladosporium sp. was tried to obtain improved stability and improved functionality. In our experiment, modification of the enzyme was tried with bovine serum albumin, ovalbumin by crosslinking using glutaraldehyde, N-bromosuccinimide, and mono-methoxy polyethylene glycol. Modified enzymes were studied for activity, temperature stability, rate constants (kd), and protection to proteolytic digestion. Modification with ovalbumin resulted in improved enzyme activity that was 10-fold higher compared to native enzyme, while modification with bovine serum albumin through glutaraldehyde cross-linking resulted in high stability of L-asparaginase that was 8.5- and 7.62-fold more compared to native enzyme at 28°C and 37°C by the end of 24 hr. These effects were dependent on the quantity of conjugate formed. Modification also markedly prolonged L-asparaginase half-life and serum stability. N-Bromosuccinimide-modified ASNase presented greater stability with prolonged in vitro half-life of 144 hr to proteolytic digestion relative to unmodified enzyme (93 h). The present work could be seen as producing a modified L-asparaginase with improved activity and stability and can be a potential source for developing therapeutic agents for cancer treatment.
Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2014 Jul 4;44(5):433-50. doi: 10.1080/10826068.2013.833110.
L-Asparaginase (ASNase), an antileukemia enzyme, is facing problems with antigenicity in the blood. Modification of L-asparaginase from Cladosporium sp. was tried to obtain improved stability and improved functionality. In our experiment, modification of the enzyme was tried with bovine serum albumi
PMID 24397716

Inducing electrocatalytic functionality in ZnO thin film by N doping to realize a third generation uric acid biosensor.

Jindal K1, Tomar M2, Gupta V3.Author information 1Department of Physics and Astrophysics, University of Delhi, Delhi 110007, India.2Department of Physics, Miranda House, University of Delhi, Delhi 110007, India.3Department of Physics and Astrophysics, University of Delhi, Delhi 110007, India. Electronic address: drguptavinay@gmail.com.AbstractA third generation uric acid biosensor has been developed by exploiting the electrocatalytic functionality of nitrogen (N) doped zinc oxide (ZnO:N) thin film matrix deposited using pulsed laser deposition technique. The electrochemistry of ZnO:N thin film based electrode is investigated by using electrochemical impedance spectroscopy and cyclic voltammetry. The obtained results demonstrate that nitrogen doping in ZnO matrix offers a striking electrocatalytic activity to the immobilized uricase towards the oxidation of analyte (uric acid) and promotes the direct transfer of electrons from active sites of enzyme onto the electrode without any mediator. In contrast to pure ZnO, ZnO:N (8% N) thin film based uric acid biosensor gives a high sensitivity of about 1.38mA/mM in the absence of mediator. Moreover, ZnO:N derived bio-electrode exhibits excellent selectivity and outstanding analytical stability and reproducibility, which enables a reliable and sensitive determination of uric acid in the serum. The ZnO:N thin film based biosensor exhibits a linear sensing response in the range from 0 to 1.0mM of uric acid concentration and the apparent Michaelis-Menten kinetic parameter (Km) is estimated to be about 0.13mM which indicates the high affinity of the prepared bio-electrode towards uric acid. The obtained results are encouraging and indicate that the ZnO:N thin film matrix offers a new and promising platform for the development of novel third generation biosensors without using any mediator.
Biosensors & bioelectronics.Biosens Bioelectron.2014 May 15;55:57-65. doi: 10.1016/j.bios.2013.11.015. Epub 2013 Dec 1.
A third generation uric acid biosensor has been developed by exploiting the electrocatalytic functionality of nitrogen (N) doped zinc oxide (ZnO:N) thin film matrix deposited using pulsed laser deposition technique. The electrochemistry of ZnO:N thin film based electrode is investigated by using ele
PMID 24362079

Density functional theory study of the structure-antioxidant activity of polyphenolic deoxybenzoins.

Xue Y1, Zheng Y2, An L2, Dou Y3, Liu Y4.Author information 1Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: xueyunsheng@xzmc.edu.cn.2Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.3School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.4Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: njuliuyi2003@gmail.com.AbstractQuantum chemical calculations based on the density functional theory (DFT) have been employed to study the relationship between the structure and the antioxidant activity of four polyphenolic deoxybenzoins (DOBs) in solvents and the gas phase. The three main working mechanisms, H-atom transfer (HAT), single electron transfer-proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET) have been investigated. The calculated results closely matched experimental values. The results obtained prove that for the HAT mechanism, the most efficient system possessed ortho-dihydroxy functionality. The results suggested that HAT would be the most favourable mechanism for explaining the radical-scavenging activity of polyphenolic DOBs in the gas phase, whereas the SPLET mechanism is the thermodynamically favourable pathway in polar solvents.
Food chemistry.Food Chem.2014 May 15;151:198-206. doi: 10.1016/j.foodchem.2013.11.064. Epub 2013 Nov 20.
Quantum chemical calculations based on the density functional theory (DFT) have been employed to study the relationship between the structure and the antioxidant activity of four polyphenolic deoxybenzoins (DOBs) in solvents and the gas phase. The three main working mechanisms, H-atom transfer (HAT)
PMID 24423521

Japanese Journal

「食品の機能性評価モデル事業」結果説明会 : 日本健康・栄養食品協会が開催 (食品の腐敗・変敗防止と人為的な食品汚染防止。)

食品工業 55(18), 71-78, 2012-09-30
NAID 40019396372

機能性に基づくコミュニティ抽出法の比較

伏見卓恭,斉藤和巳,風間一洋
情報処理学会論文誌. データベース 5(3), 26-35, 2012-09-28
本稿では,ネットワークに対する各ノードの役割・機能・立場が類似したノードからなるコミュニティを抽出することを主題とする.周辺ノードとのリンク関係の類似性,すなわち同値性を同定するための Versim 法, Simrank 法と呼ぶ従来の手法,および機能の類似するノード群を抽出する Randwalk 法の 3 手法に着目する. Randwalk 法は,ネットワーク全体でのランダムウォークにより類似経 …
NAID 110009456273