ホルミルキヌレニン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/06 15:06:00」(JST)
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N′-Formylkynurenine |
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Identifiers |
CAS number |
1022-31-7 |
PubChem |
910 |
MeSH |
N'-formylkynurenine |
Properties |
Molecular formula |
C11H12N2O4 |
Molar mass |
236.224 g/mol |
Density |
1.394 g/mL |
Boiling point |
563.4 °C (1,046.1 °F; 836.5 K) |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Y (verify) (what is: Y/N?) |
Infobox references |
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N′-Formylkynurenine is an intermediate in the catabolism of tryptophan. It is a formylated derivative of kynurenine.
See also
- Indoleamine 2,3-dioxygenase
- Kynurenine
Amino acid metabolism metabolic intermediates
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K→acetyl-CoA |
lysine→
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- Saccharopine
- Allysine
- α-Aminoadipic acid
- α-Aminoadipate
- Glutaryl-CoA
- Glutaconyl-CoA
- Crotonyl-CoA
- β-Hydroxybutyryl-CoA
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leucine→
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- α-Ketoisocaproic acid
- Isovaleryl-CoA
- 3-Methylcrotonyl-CoA
- 3-Methylglutaconyl-CoA
- HMG-CoA
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tryptophan→alanine→
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- N'-Formylkynurenine
- Kynurenine
- Anthranilic acid
- 3-Hydroxykynurenine
- 3-Hydroxyanthranilic acid
- 2-Amino-3-carboxymuconic semialdehyde
- 2-Aminomuconic semialdehyde
- 2-Aminomuconic acid
- Glutaryl-CoA
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G |
G→pyruvate→citrate
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glycine→serine→
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- glycine→creatine: Glycocyamine
- Phosphocreatine
- Creatinine
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G→glutamate→
α-ketoglutarate
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histidine→
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- Urocanic acid
- Imidazol-4-one-5-propionic acid
- Formiminoglutamic acid
- Glutamate-1-semialdehyde
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proline→
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- 1-Pyrroline-5-carboxylic acid
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arginine→
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- Ornithine
- Putrescine
- Agmatine
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other
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- cysteine+glutamate→glutathione: γ-Glutamylcysteine
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G→propionyl-CoA→
succinyl-CoA
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valine→
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- α-Ketoisovaleric acid
- Isobutyryl-CoA
- Methacrylyl-CoA
- 3-Hydroxyisobutyryl-CoA
- 3-Hydroxyisobutyric acid
- 2-Methyl-3-oxopropanoic acid
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isoleucine→
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- 2,3-Dihydroxy-3-methylpentanoic acid
- 2-Methylbutyryl-CoA
- Tiglyl-CoA
- 2-Methylacetoacetyl-CoA
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methionine→
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- generation of homocysteine: S-Adenosyl methionine
- S-Adenosyl-L-homocysteine
- Homocysteine
- conversion to cysteine: Cystathionine
- alpha-Ketobutyric acid+Cysteine
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threonine→
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propionyl-CoA→
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G→fumarate
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phenylalanine→tyrosine→
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- 4-Hydroxyphenylpyruvic acid
- Homogentisic acid
- 4-Maleylacetoacetic acid
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G→oxaloacetate
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Other |
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- glycerides
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
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English Journal
- Tryptophan oxidation catabolite, N-formylkynurenine (NFK), in photo degraded cell culture medium results in reduced cell culture performance.
- McElearney K1, Ali A1, Zang L2, Gilbert A1, Kshirsagar R1.
- Biotechnology progress.Biotechnol Prog.2015 Nov 11. doi: 10.1002/btpr.2198. [Epub ahead of print]
- Chemically defined media have been widely used in the biopharmaceutical industry to enhance cell culture productivities and ensure process robustness. These media, which are quite complex, often contain a mixture of many components such as vitamins, amino acids, metals and other chemicals. Some of t
- PMID 26560839
- Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid.
- Kang KY1, Lee SH1, Jung SM1, Park SH1, Jung BH2, Ju JH2.
- The Journal of rheumatology.J Rheumatol.2015 Nov;42(11):2003-11. doi: 10.3899/jrheum.141505. Epub 2015 Sep 1.
- OBJECTIVE: Synovial fluid (SF) is one of the most important materials that reflect the pathophysiological process of arthritis. A metabolomic and lipidomic study of SF was performed with the aim of identifying tentative diagnostic markers or therapeutic candidates for rheumatoid arthritis (RA).METHO
- PMID 26329338
- Substrate Oxidation by Indoleamine 2,3-Dioxygenase: Evidence for a Common Reaction Mechanism.
- Booth ES1, Basran J1, Lee M1, Handa S1, Raven EL2.
- The Journal of biological chemistry.J Biol Chem.2015 Oct 28. pii: jbc.M115.695684. [Epub ahead of print]
- The kynurenine pathway is the major route of L-tryptophan (L-Trp) catabolism in biology, leading ultimately to the formation of NAD+. The initial and rate-limiting step of the kynurenine pathway involves oxidation of L-Trp to N-formylkynurenine (NFK). This is an O2-dependent process and catalyzed by
- PMID 26511316
Japanese Journal
- Structural Analysis of Amino Acids, Oxidized by Reactive Oxygen Species and an Antibody against N-Formylkynurenine
- Suto Daisuke,Ikeda Yoshitaka,Fujii Junichi,Ohba Yoshihiro
- Journal of Clinical Biochemistry and Nutrition 38(2), 107-111, 2006
- … Among the compounds identified, N-formylkynurenine (NFK), a well-known oxidation product of Trp in vivo via enzymatic and non-enzymatic reactions, and its hydroxylated form were found to be major products of the reaction with singlet oxygen. …
- NAID 130004466445
- トリプトファン-ナイアシン代謝経路の中間体とニコチン酸類縁化合物のナイアシン活性効率
- 柴田 克己
- ビタミン 72(10), 515-522, 1998-10-25
- … we have concluded that tryptophan, 3-hydroxyanthranilic acid, quinolinic acid, nicotinamide N-oxide, N'-methylnicotinamide, nicotinuric acid, 3-acetylpyridine, pyridine 3-aidehyde, pyridine 3-methanol, β-picoline, or nicotinic acid N-oxide is approximately 1/10, 1/12, 1/24, 1/5, 1/2, 1/10, 1/10, 1/1, 1/1, 1/10, or 1/2 active as nicotinic acid, however, that N-formylkynurenine, kynurenine, 3-hydroxykynurenine, anthranilic acid, cinchomeronic acid, 3-cyanopyridine, 6-hydroxynicotinic acid, and pyridine 3-sulfonic acid do not have any niacin …
- NAID 110002843423
- Theoretical Analysis of Chemical Reaction in Frozen State (Part 2) : Introduction of a More Accurate Freezing Point Depression
- Murata Satoshi,Yamasaki Nobuyuki,Tanaka Fumihiko
- 九州大学農学部紀要 38(1/2), 1-7, 1993-12
- … The acceleration of the deformylation of N'-formylkynurenine in the frozen acidic solutions can be interpreted as being due to the concentration of the reactants in the liquid region in ice crystals. …
- NAID 110000017758
Related Links
- formylkynurenine for·myl·ky·nu·re·nine (fôr'məl-kī-nur'ə-nēn', -nyur'-) n. An intermediate that is formed during the breakdown of tryptophan.
- Definition of formylkynurenine in the Medical Dictionary. formylkynurenine explanation. Information about formylkynurenine in Free online English dictionary. What is formylkynurenine? Meaning of formylkynurenine medical term ...
Related Pictures
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