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English Journal

Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies.

Bergamini G1, Sigrist H2, Ferger B3, Singewald N4, Seifritz E5, Pryce CR6.
Neuropharmacology.Neuropharmacology.2016 Oct;109:306-19. doi: 10.1016/j.neuropharm.2016.03.048. Epub 2016 Mar 30.
Dopamine (DA) neurotransmission, particularly the ventral tegmental area-nucleus accumbens (VTA-NAcc) projection, underlies reward and aversion processing, and deficient DA function could underlie motivational impairments in psychiatric disorders. 6-hydroxydopamine (6-OHDA) injection is an establish
PMID 27036890

Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear.

Chen NA1, Ganella DE1, Bathgate RA2, Chen A3, Lawrence AJ1, Kim JH4.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.Eur Neuropsychopharmacol.2016 Sep;26(9):1533-40. doi: 10.1016/j.euroneuro.2016.06.002. Epub 2016 Jul 7.
The neuropeptide corticotropin-releasing factor (CRF) coordinates the physiological and behavioural responses to stress. CRF receptors are highly expressed in the ventral tegmental area (VTA), an important region for motivated behaviour. Therefore, we examined the role of CRF receptor type 1 (CRFR1)
PMID 27397862

Day HL1, Reed MM1, Stevenson CW2.
Neurobiology of learning and memory.Neurobiol Learn Mem.2016 Sep;133:196-203. doi: 10.1016/j.nlm.2016.07.014. Epub 2016 Jul 14.
Post-traumatic stress disorder (PTSD) is more prevalent in women than men. PTSD is characterized by overgeneralization of fear to innocuous stimuli and involves impaired inhibition of learned fear by cues that predict safety. While evidence indicates that learned fear inhibition through extinction d
PMID 27423522

Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats

Hiraide Sachiko,Saito Yasuhiro,Matsumoto Machiko [他],YANAGAWA Yoshiki,ISHIKAWA Shuhei,KUBO Yasunori,INOUE Sumitaka,YOSHIOKA Mitsuhiro,TOGASHI Hiroko
Journal of pharmacological sciences 119(1), 64-72, 2012-05-20
… Adult rats exposed to footshock (FS) stress during the second postnatal period (2wFS group) exhibited low levels of freezing in response to contextual fear conditioning (CFC). …
NAID 10030760346

Effects of Physical and Psychological Stress on 5-HT2A Receptor-mediated Wet-dog Shake Responses in Streptozotocin-induced Diabetic Rats.

Amano Manabu,Suemaru Katsuya,Cui Ranji,Umeda Yuichi,Li Bingjin,Gomita Yutaka,Kawasaki Hiromu,Araki Hiroaki
Acta Medica Okayama 61(4), 205-212, 2007-08-00
… Five-day exposure to physical (electric footshock) and psychological (non-footshock) stress had no signifi cant effect on the hippocampal BDNF level in diabetic or nondiabetic rats. …
NAID 120002311584