フルナリジン、塩酸フルナリジン
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
UpToDate Contents
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English Journal
- Familial and sporadic hemiplegic migraine: diagnosis and treatment.
- Pelzer N, Stam AH, Haan J, Ferrari MD, Terwindt GM.SourceDepartment of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300, RC Leiden, The Netherlands.
- Current treatment options in neurology.Curr Treat Options Neurol.2013 Feb;15(1):13-27. doi: 10.1007/s11940-012-0208-3.
- OPINION STATEMENT: Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient hemiparesis during attacks. Diagnosis is based on the International Classification of Headache Disorders criteria (ICHD-II). Two types of HM are recognized: familial (FHM) and sporadic hem
- PMID 23203776
- Pharmacologic Treatment of Pediatric Headaches: A Meta-analysis.
- El-Chammas K, Keyes J, Thompson N, Vijayakumar J, Becher D, Jackson JL.AbstractOBJECTIVE To assess the effectiveness of prophylactic headache treatment in children and adolescents. DATA SOURCES PubMed, EMBASE, Cochrane Database of Clinical Trials, and bibliography of retrieved articles through August 11, 2012. STUDY SELECTION Randomized trials of headache treatment among children and adolescents (<18 years old). INTERVENTION Any placebo-controlled trial or comparisons between 2 or more active medications. MAIN OUTCOME MEASURE Number of headaches per month. RESULTS Among 21 included trials, there were 13 placebo-controlled and 10 active comparator trials (2 also included placebo). Twenty trials focused on episodic migraines and 1 on chronic daily headaches. Drugs more effective than placebo for episodic migraines (<15 headaches per month) included topiramate (difference in headaches per month, -0.71; 95% CI, -1.19 to -0.24) and trazodone (-0.60; 95% CI, -1.09 to -0.11). Ineffective drugs included clonidine, flunarizine, pizotifen, propranolol, and valproate. A single trial of fluoxetine for chronic daily headaches found it ineffective. Patients given placebo experienced a significant (P = .03) decline in headaches, from 5.6 (95% CI, 4.52-6.77; Q = 8.14 [Cochran Q is a measure of the heterogeneity of the included studies]) to 2.9 headaches per month (95% CI, 1.66-4.08; Q = 4.72). Among the 10 active comparator trials, flunarizine was more effective than piracetam (difference in headaches per month, -2.20; 95% CI, -3.93 to -0.47) but no better than aspirin, dihydroergotamine, or propranolol. Propranolol was compared with valproate as well as behavioral treatment, and 2 studies compared different doses of topiramate; none of these trials showed significant differences. CONCLUSIONS Topiramate and trazodone have limited evidence supporting efficacy for episodic migraines. Placebo was effective in reducing headaches. Other commonly used drugs have no evidence supporting their use in children and adolescents. More research is needed.
- JAMA pediatrics.JAMA Pediatr.2013 Jan 28:1-11. doi: 10.1001/jamapediatrics.2013.508. [Epub ahead of print]
- OBJECTIVE To assess the effectiveness of prophylactic headache treatment in children and adolescents. DATA SOURCES PubMed, EMBASE, Cochrane Database of Clinical Trials, and bibliography of retrieved articles through August 11, 2012. STUDY SELECTION Randomized trials of headache treatment among child
- PMID 23358935
Japanese Journal
- 実験的アノキシアおよび脳虚血に対するカルシウム 拮抗薬塩酸エホニジピンの効果
- 松村 敏弘,古市 浩康,泉 順吉,須田 浩守,伊藤 茂,武井 峰男,西 直樹,森 正,田中 芳明,栗本 忠
- 日本薬理学雑誌 105(6), 437-446, 1995-06-01
- ジヒドロピリジン系カルシウム拮抗薬であるエホニジピンの抗アノキシアおよび抗脳虚血効果について各種アノキシアおよび脳虚血モデルを用いて検討し,ニカルジピンおよびフルナリジンの効果と比較した.エホニジピンはフルナリジンと同様にKCN誘発アノキシアおよび断頭による完全脳虚血に対して投与後6時間でも保護効果を示した.―方,ニカルジピンはこれらの系において持続的な効果はみられなかった.Asphyxicアノキ …
- NAID 10005706712
- 実験的ウサギ脳血管攣縮における tropolone 誘導体、U88999E の有効性
- 高橋 州平,Neal F.Kassell,戸島 雅彦,Douglas A.Dougherty,Kevin S.Lee
- 1993-12-01
- … U88999E, 7- [4- (4,4' difluorobenzhydryl) piperazino -1- methyl ] -4- isopropyl -2- methoxy -2,4,6- cycloheptatrien -1- one hydrochloride, is a recently - developed tropolone derivative which inhibits lipid peroxidation and calcium entry. … The potency of U88999E for relaxing preconstricted vessels was slightly less than that observed for flunarizine or diltiazem. …
- NAID 120001795589
Related Links
- 26 Mar 2002 ... Flunarizine Hydrochloride Drug Information from Drugs.com. Includes Flunarizine Hydrochloride side effects, interactions and indications.
- Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non -selective calcium entry blocker with COMBOLMIN binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive ...
Related Pictures
★リンクテーブル★
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- 英
- flunarizine
- 化
- 塩酸フルナリジン flunarizine hydrochloride
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塩酸塩、ハイドロクロライド