It was established in experiments on the rats in the acute period of modeling pituitrin-isadrin myocardial infarction the formation of nitrogen monoxide decreases along with its accelerated transformation into peroxynitrite. It was evidenced by more than double inhibition of NO synthase activity in
In experiments with the rat model of acute disorder of encephalic circulation (bilateral carotid occlusion) it was found that introduction of derivate of adamantan 1-adamantiloxy-3-morfolino-2 propanol (under conventional name ademol) in the dose 2 mg/kg intraabdominal in treatment regimen (in an ho
Mechanism for the high bias in the USP colorimetric assay for diazotizable substances in hydrochlorothiazide.
Sieh DH, Perlman S.
Journal of pharmaceutical sciences.J Pharm Sci.1984 Nov;73(11):1545-7.
The USP XX colorimetric assay for the determination of diazotizable substances in hydrochlorothiazide was studied. Colorimetric assay results of hydrochlorothiazide bulk powder and captopril-hydrochlorothiazide combination tablets were found to have a high bias when compared with HPLC. A kinetic stu
1.1. Flumethiazide (ademol) given in a dose of 500 mg. twice a day for two months has proved to be an effective antihypertensive agent in 41 per cent of patient