関: flumetasone、flumetasone pivalate

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/25 17:37:03」(JST)

wiki en

Flumetasone (INN; or flumethasone) is a corticosteroid for topical use. Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.

Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.^{[citation needed]}

References

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Synthesis and structure-activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities.

Myint M1, Bucki R2, Janmey PA3, Diamond SL4.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Jul 15;25(14):2837-43. doi: 10.1016/j.bmcl.2015.04.104. Epub 2015 May 11.
Certain membrane-active cationic steroids are known to also possess both anti-inflammatory and antimicrobial properties. This combined functionality is particularly relevant for potential therapies of infections associated with elevated tissue damage, for example, cystic fibrosis airway disease, a c
PMID 26004577

Novel spectrophotometric determination of flumethasone pivalate and clioquinol in their binary mixture and pharmaceutical formulation.

Abdel-Aleem EA1, Hegazy MA2, Sayed NW1, Abdelkawy M2, Abdelfatah RM3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Feb 5;136 Pt B:707-13. doi: 10.1016/j.saa.2014.09.085. Epub 2014 Sep 30.
This work is concerned with development and validation of three simple, specific, accurate and precise spectrophotometric methods for determination of flumethasone pivalate (FP) and clioquinol (CL) in their binary mixture and ear drops. Method A is a ratio subtraction spectrophotometric one (RSM). M
PMID 25448970

Effect-based detection of synthetic glucocorticoids in bovine urine.

Pitardi D1, Cini B, Paleologo M, Brouwer A, Behnisch P, van der Linden S, Vincenti M, Capra P, Gili M, Pezzolato M, Meloni D, Bozzetta E.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2015;32(2):194-204. doi: 10.1080/19440049.2014.996788. Epub 2015 Jan 8.
Challenges to testing for the illicit use of anabolic substances in meat-producing animals stem from the production of new synthetic compounds and the administration of low-dose cocktails to circumvent detection by the surveillance schemes of European Union member states. This work evaluated for the
PMID 25569131

Japanese Journal

Determination of flumethasone in calf urine and serum by liquid chromatography-tandem mass spectrometry

BRAMBILLA G.,BUIARELLI F.,CARTONI G. P.,COCCIOLI F.,COLAMONICI C.,FAGIOLO A.,GIANNINI C.,NERI B.
Journal of chromatography. B, Biomedical sciences and applications 755(1), 265-278, 2001-05-05
NAID 10012245142

Quantitative determination of several synthetic corticosteroids by gas chromatography-mass spectrometry after purification by immunoaffinity chromatography

DELAHAUT Ph.,JACQUEMIN P.,COLEMONTS Y.,DUBOIS M.,DE GRAEVE J.,DELUYKER H.
Journal of chromatography. B, Biomedical sciences and applications 696(2), 203-215, 1997-08-29
NAID 10024519107

副腎皮質ホルモン外用剤の皮膚におよぼす影響:—とくに皮膚萎縮とDNA合成抑制との関連について—

野本正志
西日本皮膚科 43(5), 797-803, 1981
コルチコステロイドの皮膚萎縮作用とDNA合成抑制作用の関連についてラットおよび培養ラット皮膚線維芽細胞を用いて検討した。その結果，flmethasons pivarate，triamcinolone acetonide，clobectasal propionsteでは皮膚萎縮作用もDNA合成抑制作用も強く，hydrocortisone butyrate，betamethasone valerate …
NAID 130004472751

「フルメタゾン」

Flumetasone
Systematic (IUPAC) name
	(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Identifiers
CAS Number	2135-17-3
ATC code	D07AB03 , D07XB01 (combinations), QH02AB90
PubChem	CID 16490
UNII	LR3CD8SX89
KEGG	D04208
ChEMBL	CHEMBL1201392
Synonyms	Flumethasone
Chemical data
Formula	C22H28F2O5
Molar mass	410.452 g/mol
(what is this?) (verify)