関: flumetasone pivalate、flumethasone

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/24 22:39:23」(JST)

wiki en

Flumethasone (usually as the pivalic acid ester flumethasone pivalate, trade name Locacorten or Locorten) is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

References[edit]

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

English Journal

Simultaneous detection of flumethasone, dl-methylephedrine, and 2-hydroxy-4,6-dimethylpyrimidine in porcine muscle and pasteurized cow milk using liquid chromatography coupled with triple-quadrupole mass spectrometry.

Zhang D1, Park JA1, Kim SK1, Cho SH1, Jeong D1, Cho SM1, Yi H1, Shim JH2, Kim JS1, Abd El-Aty AM3, Shin HC4.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2016 Feb 15;1012-1013:8-16. doi: 10.1016/j.jchromb.2016.01.011. Epub 2016 Jan 12.
A simple analytical method based on liquid chromatography coupled with triple-quadrupole mass spectrometry was developed for detection of the veterinary drugs flumethasone, dl-methylephedrine, and 2-hydroxy-4,6-dimethylpyrimidine in porcine muscle and pasteurized cow milk. The target drugs were extr
PMID 26797492

Synthesis and structure-activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities.

Myint M1, Bucki R2, Janmey PA3, Diamond SL4.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Jul 15;25(14):2837-43. doi: 10.1016/j.bmcl.2015.04.104. Epub 2015 May 11.
Certain membrane-active cationic steroids are known to also possess both anti-inflammatory and antimicrobial properties. This combined functionality is particularly relevant for potential therapies of infections associated with elevated tissue damage, for example, cystic fibrosis airway disease, a c
PMID 26004577

Novel spectrophotometric determination of flumethasone pivalate and clioquinol in their binary mixture and pharmaceutical formulation.

Abdel-Aleem EA1, Hegazy MA2, Sayed NW1, Abdelkawy M2, Abdelfatah RM3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Feb 5;136 Pt B:707-13. doi: 10.1016/j.saa.2014.09.085. Epub 2014 Sep 30.
This work is concerned with development and validation of three simple, specific, accurate and precise spectrophotometric methods for determination of flumethasone pivalate (FP) and clioquinol (CL) in their binary mixture and ear drops. Method A is a ratio subtraction spectrophotometric one (RSM). M
PMID 25448970

Related Pictures

★リンクテーブル★

リンク元	「フルメタゾン」「flumethasone」
拡張検索	「flumetasone pivalate」

「フルメタゾン」

Flumetasone
Systematic (IUPAC) name
	(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Legal status	?
Routes	Topical
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Identifiers
CAS number	2135-17-3
ATC code	D07AB03 , D07XB01 (combinations), QH02AB90
PubChem	CID 16490
UNII	LR3CD8SX89
KEGG	D04208
ChEMBL	CHEMBL1201392
Synonyms	(6S,8S,9S,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical data
Formula	C22H28F2O5
Mol. mass	410.452 g/mol
(what is this?) (verify)